Hans Clevers

Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA.

From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. From 2002-2012 he was director of the Hubrecht Institute in Utrecht. From 2012-2015 he was President of the Royal Netherlands Academy of Arts and Sciences (KNAW). Since June 1, 2015 he is director Research of the Princess Maxima Center for pediatric oncology.

Hans Clevers has been a member of the Royal Netherlands Academy of Arts and Sciences since 2000, a member of the American Academy of Arts and Sciences since 2012 and a member of the National Academy of Sciences of the USA since 2014. He is the recipient of several awards, including the Dutch Spinoza Award in 2001, the Swiss Louis Jeantet Prize in 2004, the Memorial Sloan-Kettering Katharine Berkan Judd Award in 2005, the Israeli Rabbi Shai Shacknai Memorial Prize in 2006, the Dutch Josephine Nefkens Prize for Cancer Research and the German Meyenburg Cancer Research Award in 2008, the Dutch Cancer Society Award in 2009, the United European Gastroenterology Federation (UEGF) Research Prize in 2010, the German Ernst Jung-Preis für Medizin in 2011, the French Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize, the Heineken Prize in 2012, the Breakthrough Prize in Life Sciences in 2013, the co-recipient of the 2015 ISSCR McEwen Award for Innovation and the Academy Professor Prize, Kazemi Award for Research Excellence in Bio-Medicine, Körber European Science Prize , I&H Wachter Award and the Swammerdam medal in 2016. He obtained two ERC Advanced Investigator grants (2008 and 2016). He is Chevalier de la Legion d’Honneur since 2005 and Knight in the Order of the Netherlands Lion since 2012.

Other activities:

  • Professor at Utrecht University
  • Advisor at Life Science Partners
  • Board Member at the AACR
  • Vice-president at the ISSCR
  • Scientific Director and Board Member at the Princess Maxima Center for pediatric oncology (paid)
  • Director at the HUB

Download his C.V. here (.pdf)

Contact: h.clevers(at)hubrecht.eu

Team membersClevers

Veerle Geurts

Technician

Veerle Geurts

Roksan Franko

Student

Marrit Putker

Postdoc

Jens Pushof

PhD student

Sigrid Kolders

Technician

Dymph Klay

PhD student

Florijn Dekkers

Postdoc

Florijn Dekkers

Talya Dayton

Postdoc

Georg Busslinger

PhD student

Jochem Bernink

Postdoc

Yotam Bar-Ephraim

Postdoc

Marie Bannier

PhD student

Marie Bannier

Kadi Lõhmussaar

PhD Student

Carola Ammerlaan

Technician

Yoshiyuki Tsukamoto

Postdoc

Tomohiro Mizutani

Postdoc

Evelien de Jongh

Technician

Georg Busslinger

Postdoc

Huili Hu

Postdoc

Joep Beumer

PhD student

Kim Boonekamp

PhD student

Lena Böttinger

Postdoc

Priyanca Asra

Technician

Jasper Mullenders

postdoc

Yorick Post

PhD Students

Jeroen Korving

Lab Assistent

Frans Schutgens

PhD Student

Else Driehuis

PhD Student

Angelos Papaspyropoulos

Postdoc

Devanjali Dutta

Postdoc

Onur Basak

Postdoc

Oded Kopper

Postdoc

Kai Kretzschmar

Postdoc

Inha Heo

Postdoc

Helmut Gehart

Postdoc

Else Driehuis

PhD student

Benedetta Artegiani

Postdoc

Anjali Balgobind

Technician

Benaissa El Haddouti

Technician

Karien Hamer

Technician

Maaike van den Born

Technician

Harry Begthel

Lab Assistant

Laura Zeinstra

Lab Assistant

Stieneke van den Brink

Lab Assistant

Wim de Lau

Senior Researcher

Wim de Lau

Johan van Es

Senior Researcher

Johan van Es

Hans Clevers

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Research

Clevers: Lgr5 stem cells, Wnt signaling & cancer

Originally focused on T lymphocyte transcription factors, we cloned Tcf1 in 1991. With the discovery that Tcf factors are the final effectors of Wnt signaling, we changed our interests to the biology of Wnt signaling in intestinal self-renewal and cancer. We identified a series of adult tissue stem cells with the novel Lgr5 marker and technologies for long-term culture of these stem cells as epithelial organoids, currently our major focus of research

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Key publications

Drost, J, van Jaarsveld, R.H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A.,Sachs, N., Overmeer, R.M., Offerhaus, G.J., Begthel, H. Korving, J., van de Wetering, M., Schwank, G. Logtenberg, M., Cuppen, E., Snippert, H.J., Medema, J.P., Kops, G. J. P. L., Clevers, H. Sequential cancer mutations in cultured human intestinal stem cells. Nature 521: 43-47 (2015)

van de Wetering, M., Francies, H.E., Francis, J.M., Bounova, G., Iorio, F., Pronk, A., van Houdt, W., van Gorp, J., Taylor-Weiner, A., Kester, L., McLaren-Douglas, A., Blokker, J., Jaksani, S., Bartfeld, S., Volckman, R., van Sluis, P., Li, V.S.W., Seepo, S., Sekhar Pedamallu, C., Cibulskis, C., Carter, S.L., McKenna, A., Lawrence, M.S., Lichtenstein, L., Stewart, C., Koster, J., Versteeg, R., van Oudenaarden, A., Saez-Rodriguez, J., Vries, R.G.J., Getz, G., Wessels, L., Stratton, M.R., McDermott, U., Meyerson, M., Garnett, M.J., Clevers, H. Prospective derivation of a ‘Living Organoid Biobank’ of colorectal cancer patients.
Cell 161: 933-945 (2015)

Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M., Ellis, E., van Wenum, M., Fuchs, S., de Ligt, J., van de Wetering, M., Sasaki, N., Boers, S., Kemperman, H., de Jonge, J. IJzermans, J., Niewenhuis, E., Hoekstra, R., Strom, S., Vries, R., van der Laan, L., Cuppen, E., Clevers, H. Long-term culture of genome-stable bipotent stem cells from adult human live. Cell 160: 299-312 (2015)

Sato, T., Vries, R., Snippert, H., van de Wetering, M., Barker, N., Stange, D., van Es, J., Abo, A., Kujala, P., Peters, P., Clevers, H. Single lgr5 gut stem cells build crypt-villus structures in vitro without a stromal niche. Nature 459 : 262-265 (2009)

Barker, N., van Es, J.H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Korving, J., Begthel, H., Peters, P.C., Clevers, H. Identification of stem cells in small intestine and colon by a marker gene LGR5. Nature 449: 1003-1007 (2007)

All publications

IκBNS enhances T follicular helper cell differentiation and function as downstream of Ascl2
2016 in21267

JunichiHosokawa, KotaroSuzuki, KazuyukiMeguro, ShigeruTanaka, YukoMaezawa, AkiraSuto, LisaFujimura, AkemiSakamoto, HansClevers, OsamuOhara, HiroshiNakajima

Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells
2016 in21315

PleunHombrink, ChristinaHelbig, Ronald ABacker, BerberPiet, Anna EOja, ReginaStark, GisoBrasser, AldoJongejan, René EJonkers, BenjaminNota, OnurBasak, Hans CClevers, Perry DMoerland, DerkAmsen, René A Wvan Lier

Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
2016 in15819

ZacharySteinhart, ZvezdanPavlovic, MeghaChandrashekhar, TraverHart, XiaoweiWang, XiaoyuZhang, MélanieRobitaille, Kevin RBrown, SrideviJaksani, RenéOvermeer, Sylvia FBoj, JarrettAdams, JamesPan, HansClevers, SachdevSidhu, JasonMoffat, StéphaneAngers

Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells
2016 in6100153018

OnurBasak, JoepBeumer, KayWiebrands, HiroshiSeno, Alexandervan Oudenaarden, HansClevers

Designer matrices for intestinal stem cell and organoid culture
2016 in21206

NikolceGjorevski, NormanSachs, AndreaManfrin, SonjaGiger, Maiia EBragina, PalomaOrdóñez-Morán, HansClevers, Matthias PLutolf

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
2016 in21100242814

Carla SVerissimo, René MOvermeer, BasPonsioen, JarnoDrost, SanderMertens, IngridVerlaan-Klink, Bastiaan vanGerwen, Mariekevan der Ven, Marc van deWetering, David AEgan, RenéBernards, HansClevers, Johannes LBos, Hugo JSnippert

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research
2016 in21121

Paul WTetteh, KaiKretzschmar, HarryBegthel, Maaikevan den Born, JeroenKorving, Folkert H MMorsink, HennerFarin, Johan Hvan Es, G Johan AOfferhaus, HansClevers

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration
2016 in14090

JoepBeumer, HansClevers

Tissue-specific mutation accumulation in human adult stem cells during life
2016 in21206

FrancisBlokzijl, Joepde Ligt, MyrtheJager, ValentinaSasselli, SophieRoerink, NobuoSasaki, MeritxellHuch, SanderBoymans, EwartKuijk, PjotrPrins, Isaac JNijman, InigoMartincorena, MichalMokry, Caroline LWiegerinck, SabineMiddendorp, ToshiroSato, GeraldSchwank, Edward E SNieuwenhuis, Monique M AVerstegen, Luc J Wvan der Laan, Jeroende Jonge, Jan N MIJzermans, Robert GVries, Marcvan de Wetering, Michael RStratton, HansClevers, EdwinCuppen, Rubenvan Boxtel

Organoids
2016 in18525

KaiKretzschmar, HansClevers

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
2016 in5800207366

LauraBroutier, AmandaAndersson-Rolf, Christopher JHindley, Sylvia FBoj, HansClevers, Bon-KyoungKoo, MeritxellHuch

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon
2016 in21121

NobuoSasaki, NormanSachs, KayWiebrands, Saskia I JEllenbroek, AriannaFumagalli, AnnaLyubimova, HarryBegthel, Maaikevan den Born, Johan Hvan Es, Wouter RKarthaus, Vivian S WLi, CarmenLópez-Iglesias, Peter JPeters, Jaccovan Rheenen, Alexandervan Oudenaarden, HansClevers

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation
2016 in6100153018

CarmenDominguez-Brauer, ZhenyueHao, Andrew JElia, Jérôme MFortin, RobertNechanitzky, Patrick MBrauer, YiSheng, Miyeko DMana, Iok In ChristineChio, JillianHaight, AaronPollett, RobertCairns, LeanneTworzyanski, SatoshiInoue, ColinReardon, AnaMarques, JenniferSilvester, Maureen ACox, AndrewWakeham, Omer HYilmaz, David MSabatini, Johan Hvan Es, HansClevers, ToshiroSato, Tak WMak

Who Is in the Driver's Seat
2016 in18606

JarnoDrost, HansClevers

Analysis of neural crest-derived clones reveals novel aspects of facial development
2016

MarketaKaucka, EvgenyIvashkin, DanielGyllborg, TomasZikmund, MarketaTesarova, JozefKaiser, MengXie, JulianPetersen, VassilisPachnis, Silvia KNicolis, TianYu, PaulSharpe, ErnestArenas, HjalmarBrismar, HansBlom, HansClevers, UeliSuter, Andrei SChagin, KajFried, AndreasHellander, IgorAdameyko

Organoid biobanking
2016 in22088

Sarah NBoers, Johannes Jmvan Delden, HansClevers, Annelien LBredenoord

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis
2016 in19700174677

Johanna FDekkers, GitteBerkers, EvelienKruisselbrink, AnnelotteVonk, Hugo Rde Jonge, Hettie MJanssens, InezBronsveld, Eduard Avan de Graaf, Edward E SNieuwenhuis, Roderick H JHouwen, Frank PVleggaar, Johanna CEscher, Yolanda Bde Rijke, Christof JMajoor, Harry G MHeijerman, Karin Mde Winter-de Groot, HansClevers, Cornelis Kvan der Ent, Jeffrey MBeekman

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
2016 in6100153018

DominicGrün, Mauro JMuraro, Jean-CharlesBoisset, KayWiebrands, AnnaLyubimova, GitanjaliDharmadhikari, Maaikevan den Born, Johanvan Es, ErikJansen, HansClevers, Eelco J Pde Koning, Alexandervan Oudenaarden

RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation
2016 in28366

Helen H NYan, Jeffrey C WLai, Siu LunHo, Wai KeungLeung, Wai LunLaw, Janet F YLee, Anthony K WChan, Wai YinTsui, Annie S YChan, Bernard C HLee, Sarah S KYue, Alice H YMan, HansClevers, Siu TsanYuen, Suet YiLeung

Modeling Development and Disease with Organoids
2016 in18434

HansClevers