Mattiroli: Chromatin structure and dynamics

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The Mattiroli group studies chromatin dynamics during DNA replication to understand how chromatin organization is propagated through cell division.

Chromatin organisation determines cell identity. Chromatin encodes the genetic and epigenetic information of the cell. Genetic and epigenetic information need to be accurately propagated through cell division, to prevent transformations that lead to diseases such as cancer.
At every cell cycle, DNA and chromatin organization are replicated. The mechanisms that control the replication of chromatin structures are largely unknown.

We use biochemical, structural and cell biology approaches to study chromatin dynamics during DNA replication at the molecular level. Moreover, we aim to understand how chromatin replication affects cellular life and disease development.

Key publicationsView all publications

Structure of histone-based chromatin in archaea

Mattiroli F*, Bhattacharyya S*, Dyer PN, White AE, Sandman K, Burkhart BW, Byrne KR, Lee T, Ahn NG, Santangelo TJ, Reeve JN, Luger K

Science 357(6351):609-612

Download|2017

DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNA replication

Mattiroli F*, Gu Y*, Yadav T, Balsbaugh JL, Harry MR, Findlay ES, Liu Y, Radebaugh CA, Stargell LA, Ahn NG, Whitehouse I, Luger K

Elife 6:e22799

Download|2017

Sci Rep. 7:46274

Download|2017

Nat Commun. 5:3291

Download|2014

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

Mattiroli F, Vissers JHA, van Dijk WJ, Ikpa P, Citterio E, Vermeulen W, Marteijn JA, Sixma TK

Cell 150(6):1182-95

Download|2012

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

Mallette FA, Mattiroli F, Cui G, Young LC, Hendzel MJ, Mer G, Sixma TK, Richard S

EMBO J. 31(8):1865-78

Download|2012

Group leader

Francesca Mattiroli

Francesca Mattiroli is a group leader at the Hubrecht Institute since January 2018. Her group investigates chromatin dynamics during DNA replication and repair. The Mattiroli group uses biochemical reconstitutions, structural approaches and cell biology to elucidate the biophysical and structural properties of chromatin and its key regulatory factors, such as histone chaperones. Chromatin organisation controls cell fate and survival, and it is often deregulated in diseases such as cancer. By determining the molecular basis for chromatin control of cell identity, we contribute to the development of potential new strategies for cancer treatments.

Scientific training and positions

Awards 


Group members

Francesca Mattiroli

Group Leader

Inge Rondeel

Technician

Fabian Gruss

Postdoc

Bruna Eckhardt

PhD Student

Jan Dreyer

PhD Student

Clément Rouillon

PhD Student

Alex Verkennis

Student

Gudbjorg Eva Gudjonsdottir

Student

Maaike Steenkamp

Student

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Open positions for PhD students and PostDocs

Open positions for Master Students