Kind: Developmental epigenomics

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The Kind group uses a combination of single-cell genomics and microscopy methods to study the role of chromatin and epigenetics in gene-regulation control, with a focus on early mouse embryonic development and tumorigenesis.

The aim of the lab is to understand the principles governing cellular decision-making. We are interested in how cells acquire new identities and traits in lineage specification events in mice and in cancer. To this end we employ and continuously develop novel single-cell technologies to delineate these processes with high sensitivity and accuracy.

Key words: Single-cell genomics, epigenetics, spatial genome organization, bioinformatics, gene-regulation, embryogenesis, tumorigenesis

Key publicationsView all publications

Nature Biotechnology 37:766-772

Download|2019

Genome–lamina interactions are established de novo in the early mouse embryo

Borsos M, Perricone SM [...] Torres-Padilla M and Kind J

Nature 569: 429-433

Download|2019

Curr Opin Genet Dev 55:19-25

Download|2019

Genome-wide maps of nuclear lamina interactions in single human cells.

Kind J, Pagie L [...] van Oudenaarden A and van Steensel B

Cell 163: 134-147.

Download|2015

Single-cell dynamics of genome-nuclear lamina interactions.

Kind J, Pagie L [...] Bickmore WA and van Steensel B

Cell 153: 178-192.

Download|2013

Cell 133: 813-828.

Download|2008

Group leader

Jop Kind

Jop Kind is group leader at the Hubrecht Institute. His group is interested in elucidating the role of chromatin and nuclear architecture in gene-regulation and DNA-repair. The Kind group develops new techniques, such as the recently developed DamID and m6ATracer techniques. These techniques enable them to study genome architecture and protein-DNA interactions in high resolution in single cells. The Kind group uses these techniques to study the role of genome architecture and chromatin context in temporal and spatial control of gene expression in development and disease.

Scientific training and positions

Awards


Group members

Jop Kind

Group Leader

Sandra de Vries

Technician

Ramada van Beek

Technician

Ellen Boele

Technician

Koos Rooijers

Postdoc

Isabel Guerreiro

Postdoc

Leila Nahidiazar

Postdoc

Tess Korthout

Postdoc

Christian Valdes

Postdoc

Kim de Luca

PhD Student

Franka Rang

PhD Student

Corina Markodimitraki

PhD Student

Silke Lochs

PhD Student

Samy Kefalopoulou

PhD Student

We are always on the lookout for enthousiastic colleagues. If you are interested, please contact Jop Kind.

Job openings

Bioinformatician (Postdoc/PhD) full time

Research group

Kind group

Start date

Asap

Location

Utrecht, Science Park.

Period

Full time