Kind: Chromatin organization

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The Kind group studies the regulation of gene expression in single cells by developing and using novel microscopy and genomics based techniques.

The genomic era as greatly advanced our understanding of cellular processes and disease mechanisms. Yet, our knowledge about the regulation of the genome is generally based on datasets derived from large cell populations that provide an ensemble average interpretation of the biological system and disregard existing cell-to-cell heterogeneity.

Key publications

Simultaneous quantification of protein–DNA contacts and transcriptomes in single cells

Rooijers, K., Markodimitraki, C.M., Rang, F.J., de Vries, S.S., Chialastri, A., de Luca, K.L., Mooijman, D., Dey, S.S., Kind, J.

Nature Biotechnology


Genome–lamina interactions are established de novo in the early mouse embryo

Borsos, M., Perricone, S.M., Schauer, T. Pontabry, J., de Luca, K.L., de Vries, S.S., Ruiz-Morales, E.R., Torres-Padilla, M., Kind, J.

Nature 569: 429-433


Genome-wide maps of nuclear lamina interactions in single human cells.

Kind, J., Pagie, L., de Vries, SS., Azar, LN., Dey, SS., Bienko, M., Zhan, Y., Lajoie, B., de Graaf ,CA., Amendola, M., Imakaev, M., Fudenberg, G., Mirny, L., Jalink, K., Dekker, J., van Oudenaarden, A., van Steensel, B

Cell 163: 134-147.


Single-cell dynamics of genome-nuclear lamina interactions.

Kind, J., Pagie, L., Ortabozkoyun, H., Boyle, S., de Vries, S.S., Janssen, H, Amendola, M., Nolen, L.D., Bickmore, W.A., van Steensel, B.

Cell 153: 178-192.


Curr Opin Cell Biol. 22: 320-325.


Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila.

Kind, J., Vaquerizas, J.M., Gebhardt, P., Gentzel, M., Luscombe, N.M., Bertone, P., Akhtar, A.

Cell 133: 813-828.


Systematic protein location mapping reveals five principal chromatin types in Drosophila cells

Filion, G.J., van Bemmel, J.G., Braunschweig, U., Talhout, W., Kind, J., Ward, L.D., Brugman, W., de Castro, I.J., Kerkhoven, R.M., Bussemaker, H.J., van Steensel, B.

Cell 143: 212-224.


Group leader

Jop Kind

Jop Kind is group leader at the Hubrecht Institute. His group is interested in elucidating the role of chromatin and nuclear architecture in gene-regulation and DNA-repair. The Kind group develops new techniques, such as the recently developed DamID and m6ATracer techniques. These techniques enable them to study genome architecture and protein-DNA interactions in high resolution in single cells. The Kind group uses these techniques to study the role of genome architecture and chromatin context in temporal and spatial control of gene expression in development and disease.

Scientific training and positions


Group members

Jop Kind

Principal Investigator

Sandra de Vries


Ramada van Beek


Ellen Boele


Sara Perricone


Koos Rooijers


Isabel Guerreiro


Leila Nahidiazar


Tess Korthout


Kim de Luca

PhD Student

Franka Rang

PhD Student

Corina Markodimitraki

PhD Student

Silke Lochs

PhD Student

Samy Kefalopoulou

PhD Student

David Hueting


We are always on the lookout for enthousiastic colleagues. If you are interested, please contact Jop Kind.