Bakkers: Cardiac Development and Genetics

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The Bakkers group studies the genetics of cardiac development, regeneration and disease using the zebrafish model system.

Wide ranges of cardiac diseases are caused by genetic alterations, which affect normal cardiac development or function. We use the zebrafish model to identify genes and mechanisms that regulate normal heart development, function and regeneration, and that can contribute to cardiac diseases in humans. In addition, we model genetic cardiac diseases in zebrafish. The projects in the lab use a wide range of approaches including genetics, in vivo microscopy, tomo-seq and single-cell RNA-seq.

PublicationsView all publications

Dev Cell;32(5):631-9

Download|2015

Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm.

Chetaille, P.*, Côté, J.*, [...], Bakkers, J., Andelfinger, G.

Nat Genet;46(11):1245-9.

Download|2014

Genome-wide RNA tomography in the zebrafish embryo.

Junker, J.P.*, Noël, E.S*., [...], Bakkers, J*., van Oudenaarden, A.

Cell. 23;159(3):662-75.

Download|2014

A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality.

Noël ES, Verhoeven M, [...], den Hertog J, Bakkers J

Nat Commun;4:2754

Download|2013

Group leader

Jeroen Bakkers

Jeroen Bakkers is group leader at the Hubrecht Institute and professor of Molecular Cardiogenetics at the University Medical Center Utrecht. His group uses the zebrafish (Danio rerio) as a model system to study various processes. The research lines of the Bakkers group include unraveling the genetics of normal cardiac development and body axis formation during development, investigating the molecular mechanisms of heart regeneration in the zebrafish and how this can be compared to heart injury in the mammals, and modeling of human (cardiac) disease in the zebrafish to unravel biological mechanisms behind the disease and to identify new drug targets.

Scientific training and positions

Current other activities


Group members

Jeroen Bakkers

Principal Investigator

Sonja Chocron

Technician

Yeszamin Onderwater

Technician

Federico Tessadori

Postdoc

Laurence Garric

Postdoc

Silja Burkhard

Postdoc

Phong Nguyen

Postdoc

Lotte Koopman

PhD Student

Sven Willekers

PhD Student

Melanie Laarman

PhD Student

Dennis de Bakker

PhD Student

Sarah Kamel

PhD Student

Hessel Honkoop

PhD Student

Mariam Hababa

Student

Kim Visser

Student

Jonas Mars

Student

Lab alumni