Kops: Chromosome segregation

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The Kops group studies the processes involved in chromosome segregation during cell division, with a focus on molecular mechanisms, evolution and chromosomal instability.

The main aim of our research is to understand how the cell division process gives rise to two genetically identical daughter cells. We are particularly interested in the processes that ensure correct chromosome segregation during mitosis. This is not only fascinating from a molecular perspective (how does a cell do that) and an evolutionary perspective (How has this intricate process evolved and are there meaningful differences between species?) but also has implications for health and disease. Errors in chromosome segregation are a major cause for birth defects and embryonic lethality in humans, and the most common genetic alteration in human tumors is aberrant chromosome numbers, called aneuploidy. Finally, as we and others have shown, errors in chromosome segregation during mitosis have dramatic secondary consequences on genome integrity, including translocations, deletions and chromosome shattering (chromothripsis).

Key publicationsView all publications

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis.

Sacristan C, Ahmad MUD, Keller J, Fermie J, Groenewold V, Tromer E, Fish A, Melero R, Carazo JM, Klumperman J, Musacchio A, Perrakis A, Kops GJPL.

Nature Cell Bioloy 20 (2018) 800-810.

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Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation.

Yost S, De Wolf B, Hanks S, Zachariou A, Marcozz C, Clarke M, De Voer RM, Etemad B, Uijttewaal E, Ramsay E, Wylie H, Elliott A, Picton S, Smith A, Smithson S, Seal S, Ruark E, Houge G, Pines J, Kops GJPL*, Rahman N*.

Nat Genet. 49 (2017), 1148-1151.

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* authors contributed equally

EMBO Reports 18 (2017), 1559-1571.

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Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.

Hiruma, Y, Sacristan C, Pachis ST, Adamopoulos A, Kuijt T, Ubbink M, Von Castelmur E, Perrakis A, Kops GJPL.

Science 348 (2015), 1264-1267.

Download|2015

Trends Cancer 2 (2016), 561-571.

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Sequential multisite phospho-regulation of KNL1-BUB3 interfaces at mitotic kinetochores.

Vleugel M, Omerzu M, Groenewold V, Hadders MA, Lens SM, Kops GJPL.

Mol Cell 57 (2015), 824-35.

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Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.

Nijenhuis W, Vallardi G, Van den Dikkenberg A, Kops GJPL*, Saurin AT*.

Nat Cell Biol. 16 (2014), 1257-64.

Download|2014

* authors contributed equally

Dev Cell 23 (2012), 745-755.

Download|2012

The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.

Suijkerbuijk SJE, Van Dam TJP, Karagöz GE, Von Castelmur E, Hubner NC, Duarte AMS, Vleugel M, Perrakis A, Rüdiger SGD, Snel B, Kops GJPL.

Dev Cell 22 (2012), 1321-9.

Download|2012

Chromosome segregation errors as a cause of DNA damage and structural chromosome aberration.

Janssen A, Van der Burg, M, Szuhai, K, Kops GJPL*, Medema RH*.

Science 333 (2011), 1895-8.

Download|2011

* authors contributed equally

Proc Natl Acad Sci U S A 106 (2009), 19108-13.

Download|2009

* authors contributed equally

Mps1 phosphorylates borealin to control aurora B activity and chromosome alignment.

Jelluma N, Brenkman AB, Van den Broek NJF, Cruijsen CWA, Van Osch MHJ, Lens SMA, Medema RH and Kops GJPL.

Cell 132 (2008) 233-246.

Download|2008

Group leader

Geert Kops

Geert Kops is group leader at the Hubrecht Institute, professor of Molecular Tumor Cell Biology at the University Medical Center Utrecht and Scientific Director of Oncode Institute. His group is interested in the processes that ensure correct chromosome segregation during cell division. Errors in chromosome segregation can cause birth defects and embryonic lethality in humans and cause aneuploidy, the most common genetic alteration in tumors. The Kops group studies the signaling networks that regulate chromosome segregation, the evolution of cell division processes and the role of chromosomal instability in cancer.

Scientific training and positions

Awards

Current other activities


Group members

Geert Kops

Principal Investigator

Anko de Graaff

Technician

Pim Toonen

Technician

Ajit Quirindongo

Technician

Antoinette Teixeira

Technician

Claudia Rebel

Technician

Nannette Jelluma

Senior Researcher

Carlos Sacristan Lopez

Postdoc

Eelco Tromer

Postdoc

Banafsheh Etemad

Postdoc

Jingchao Wu

Postdoc

Xiaorong Zhang

Postdoc

Spiros Pachis

PhD Student

Ana Farinha Bolhaqueiro

PhD Student

Timo Kuijt

PhD Student

Richard van Jaarsveld

PhD Student

Wilma Hoevenaar

PhD Student

Bas de Wolf

PhD Student

Sjoerd Klaasen

PhD Student

Enya Vermeulen

Student

Sonja Weterings

Student

Jolien van Hooff

Guest

Vincent Groenewold

Guest

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