Galli: Cell cycle regulation

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The Galli group studies the regulation of the cell cycle during development and tissue formation.

Over the course of evolution, organisms have developed variations in their cell cycle programs to be able to generate and maintain a plethora of different cell types and tissues.  Our lab uses a variety of model systems, such as the nematode C. elegans, as well as in vitro culture systems, to address fundamental questions in cell cycle control during development and tissue formation.

Key publications

aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division.

Galli M, Muñoz J, Portegijs V, Boxem M, Grill SW, Heck AJ, van den Heuvel S

Nat Cell Biol. 13(9):1132-1138

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Annual Review of Genetics 42:389-411

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Group leader

Matilde Galli

Matilde Galli is Hubrecht Fellow at the Hubrecht Institute. Her group studies how the cell cycle is controlled in different cell types within a multicellular organism. They use genetics, imaging and sequencing based approaches in C. elegans and mammalian systems to explore the establishment and function of various cell cycle programs. The group is particularly interested in understanding how different cell types respond to defects in cell division by activation of the spindle assembly checkpoint (SAC). Moreover, the Galli group studies cell cycles that lead to polyploidization, such as endoreplication and endomitosis, and how these cycles are regulated in normal physiology and in disease.   

Scientific training and positions


Group members

Matilde Galli

Principal Investigator

Reinier van der Palen

Technician

Gabriella Darmasaputra

PhD Student

Lotte van Rijnberk

PhD Student

Emma van Grinsven

Student

Tanne van der Wal

Student

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