Galli: Cell cycle regulation

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The Galli group studies cell-cycle control during development and tissue formation.

Over the course of evolution, organisms have developed variations in their cell cycle programs to be able to generate and maintain a plethora of different cell types and tissues.  Our lab uses a variety of model systems, such as the nematode C. elegans, as well as in vitro culture systems, to address fundamental questions in cell cycle control during development and tissue formation.

Key publications

aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division.

Galli M, Muñoz J, Portegijs V, Boxem M, Grill SW, Heck AJ, van den Heuvel S

Nat Cell Biol. 13(9):1132-1138


Annual Review of Genetics 42:389-411


Group leader

Matilde Galli

Matilde Galli is Hubrecht Fellow at the Hubrecht Institute. Her group studies how the cell cycle is controlled in different cell types within a multicellular organism. They use genetics, imaging and sequencing based approaches in C. elegans and mammalian systems to explore the establishment and function of various cell cycle programs. The group is particularly interested in understanding how different cell types respond to defects in cell division by activation of the spindle assembly checkpoint (SAC). Moreover, the Galli group studies cell cycles that lead to polyploidization, such as endoreplication and endomitosis, and how these cycles are regulated in normal physiology and in disease.   

Scientific training and positions

Group members

Matilde Galli

Group Leader

Noam Perry Levy


Gabriella Darmasaputra

PhD Student

Cindy Geerlings

PhD Student

Ramon Barrull Mascaró

PhD Student

Maxime Klostermann


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Research group

Galli group

Start date



Utrecht Science Park