Korswagen: Developmental Biology

Back to research groups

The Korswagen group combines new methods in gene expression analysis with model organism genetics to investigate molecular mechanisms in developmental biology.

We focus on the genetic pathways that control cell fate determination and cell migration. As part of our research, we are developing new methods for multidimensional gene expression analysis. As a model, we use Caenorhabditis elegans. This small nematode offers a powerful genetic system to understand evolutionarily conserved mechanisms with single cell resolution in vivo.

 

Key publicationsView all publications

Cell intrinsic modulation of Wnt signaling controls neuroblast migration in C. elegans.

Mentink RA, Middelkoop TC, Rella L, Ji N, van Oudenaarden A, Korswagen HC.

Developmental Cell 31: 188-201.

Download|2014

A SNX3-dependent Retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion.

Harterink M, Port F, Lorenowicz M, McGough I, Silhankova M, Betist M, van Weering J, van Heesbeen R, Middelkoop T, Basler K, Cullen P, Korswagen HC.

Nature Cell Biology 13:914-923.

Download|2011

See also: News & Views Highlight in EMBO J

Functional interaction between beta-catenin and FOXO in oxidative stress signaling.

Essers MA, de Vries-Smits LMM, Barker N, Polderman PE, Burgering BMT, Korswagen HC.

Science 308: 1181-1184.

Download|2005

Feedback control of gene expression variability in the Caenorhabditis elegans Wnt pathway.

Ji N, Middelkoop TC, Mentink RA, Betist MC, Tonegawa S, Mooijman D, Korswagen HC*, van Oudenaarden A*

Cell 155: 869-880.

Download|2013

*Joint senior/corresponding authors. See also: Cell video abstract

Wnt signaling requires retromer dependent recycling of MIG-14/Wls in Wnt producing cells.

Yang PT, Lorenowicz M, Silhankova M, Coudreuse DYM, Betist MC, Korswagen HC.

Developmental Cell 14: 140-147.

Download|2008

Wnt gradient formation requires retromer function in Wnt producing cells.

Coudreuse DYM, Roel G, Betist MC, Destree O, Korswagen HC.

Science 312: 921-924.

Download|2006

Group leader

Rik Korswagen

Rik Korswagen is a group leader at the Hubrecht Institute and professor of Molecular Developmental Genetics at Utrecht University. His group is interested in the mechanism of Wnt signal transduction in development and disease and uses the C. elegans model system to study Wnt signaling at single cell resolution. His current research focuses on canonical and non-canonical Wnt signaling mechanisms in cell migration, which he studies using a combination of genetics, time-lapse confocal imaging, RNA sequencing and single molecule mRNA in situ hybridization.

Scientific training and positions

Awards

Current other activities


Group members

Rik Korswagen

Group Leader

Marco Betist

Lab Assistant

Euclides Povoa

PhD Student

Lorenzo Rella

PhD Student

Annabel Ebbing

PhD Student

Christa van der Veen

PhD Student

Erik Schild

PhD Student

Jonas Mars

PhD Student

Demi Wernaart

Student

Laura Schwarz

Student

Eva Gossink

Student

Julian Arts

Student

Lina Soto

Guest

Show all group members

Videos