van Rooij: Molecular Cardiology

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The Van Rooij group aims to delineate signaling pathways relevant for heart repair and remodeling that can eventually lead to effective treatment options to minimize the loss of cardiomyocytes and/or reverse the adverse remodeling processes in the diseased heart.

A major challenge in the field of cardiac biology is to decipher the relevance of different signaling mechanisms that are relevant during disease. Using mouse genetics in combination with novel sequencing technologies our lab is able to identify key cell types or candidate factors important for specific remodeling and repair processes of the heart. These factors are studied in detail by molecular gain and loss-of-function studies, applying both genetics and oligonucleotide-based approaches.

Key publications

Tomo-seq identifies SOX9 as a key regulator of cardiac fibrosis during ischemic injury.

Lacraz GPA, Junker JP, Gladka MM, Molenaar B, Scholman KT, Vigil-Garcia M, Versteeg D, de Ruiter H, Vermunt MW, Creyghton MP, Huibers MMH, de Jonge N, van Oudenaarden A, van Rooij E.

Circulation 136(15):1396-1409

Download|2017

Postnatal cardiac gene-editing using CRISPR/Cas9 with AAV9-mediated delivery of short guide RNAs results in mosaic gene disruption.

Johansen AK, Molenaar B, Versteeg D, Leitoguinho AR, Demkes CJ, Spanjaard B, de Ruiter H, Akbari Moqadam FA, Kooijman L, Zentilin L, Giacca M, van Rooij E.

Circ Res. 121(10):1168-1181.

Download|2017

Single-cell sequencing of the healthy and diseased heart reveals Ckap4 as a new modulator of fibroblasts activation.

Gladka MM, Molenaar B, de Ruiter H, Versteeg D, Lacraz GPA, van der Elst S, Huibers MMH, van Oudenaarden A, van Rooij E.

Circulation Jan 31

Download|2018

The efficacy of cardiac anti-miR-208a therapy is stress dependent.

Eding JE, Demkes CJ, Lynch JM, Seto AG, Montgomery RL, Semus HM, Jackson AL, Isabelle M, Chimenti S, van Rooij E.

Mol Ther. 25(3):694-704.

Download|2017

Inhibition of miR-15 protects against cardiac ischemic injury.

Hullinger TG, Montgomery RL, Seto AG, Dickinson BA, Semus HM, Lynch JM, Dalby CM, Robinson K, Stack C, Latimer PA, Hare JM, Olson EN, van Rooij E.

Circ Res 6 110(1): 71-81.

Download|2012

N Engl J Med. 374(1):85-7.

Download|2016

MicroRNA mimicry blocks pulmonary fibrosis.

Montgomery RL, Yu G, Latimer PA, Stack C, Robinson K, Dalby CM, Kaminski N, van Rooij E

EMBO Mol Med 6(10):1347-56.

Download|2014

Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure.

Montgomery RL, Hullinger TG, Semus HM, Dickinson BA, Seto AG, Lynch JM, Stack C, Latimer PA, Olson EN, van Rooij E.

Circulation 124(14): 1537-1547.

Download|2011

Control of stress-dependent cardiac growth and gene expression by a microRNA.

van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN.

Science 316(5824): 575-579.

Download|2007

Group leader

Eva van Rooij

Eva van Rooij is group leader at the Hubrecht Institute and professor of Molecular Cardiology at the University Medical Center Utrecht. Her group aims to unveil the molecular signaling pathways that are relevant for cardiac disease. The Van Rooij group combines mouse genetics and models of heart disease with novel sequencing technologies such as single-cell sequencing and Tomo-seq to identify key cell types or candidate factors important for specific remodeling and repair processes of the heart. The ultimate goal is to identify pathways that can eventually lead to effective treatment options to minimize the loss of cardiomyocytes and/or reverse the adverse remodeling processes in the diseased heart.

Scientific training and positions

Awards

Current other activities


Group members

Eva van Rooij

Principal Investigator

Hesther de Ruiter

Technician

Daniëlle Versteeg

Technician

Jantine Monshouwer-Kloots

Technician

Lieneke Kooijman

Technician

Ilaria Perini

Technician

Grégory Lacraz

Postdoc

Monika Gladka-de Vries

Postdoc

Kees Jan Boogerd

Postdoc

Jenny Tsui

Postdoc

Marjolein Droog

Postdoc

Joep Eding

PhD Student

Bas Molenaar

PhD Student

Marta Vigil-Garcia

PhD Student

Arwa Kohela

PhD Student

Maya Wright Clark

PhD Student

Sebastiaan van Kampen

PhD Student

Anne de Leeuw

PhD Student

Eirini Kyriakopoulou

Student

Kharishma Patel

Student

Britt van der Swaan

Student

Lab alumni

Open Postdoc position

Job openings

Postdoc

Research group

van Rooij group

Start date

Asap

Location

Utrecht Science Park

Period

Full time