Hiiragi: Multi-cellular self-organization

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The Hiiragi group studies robustness in development and aims to understand the design principle of self-organizing multi-cellular systems.

Self-organization is a defining feature of living systems and entails complex interplay between molecular, cellular and mechanical signals across various spatio-temporal scales. Using early mammalian embryos as a model, the Hiiragi group adopts a variety of methods including genetics, microscopy, biophysics, engineering and modelling, to investigate how self-organised forms and patterns emerge from a spherical mass of cells.

Group leader

Takashi Hiiragi

Takashi Hiiragi is group leader at the Hubrecht Institute.  The Hiiragi group aims to understand what defines multi-cellular living systems. In particular, the group studies the design principle of tissue self-organization, using early mammalian embryos as a model system. To this end, they developed an experimental framework that integrates biology, physics and mathematics. Their recent studies led to a model in which feedback between cell fate, polarity, and cell and tissue mechanics underlies multi-cellular self-organization. The group adopts a wide variety of experimental strategies including embryology, genetics, advanced microscopy, biophysics, engineering and theoretical modelling, in order to address fundamental questions in cell and developmental biology.

Scientific training and positions

Awards and grants


Group members

Portrait picture Takashi Hiiragi

Takashi Hiiragi

Group Leader

Portrait picture Lidia Perez

Lidia Perez

Technician

Portrait picture Dimitri Fabreges

Dimitri Fabrèges

Postdoc

Takafumi Ichikawa

Postdoc

Portrait picture Hui Ting Zhang

Hui Ting Zhang

PhD Student

Portrait picture Prachiti Moghe

Prachiti Moghe

PhD Student

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Open positions

Positions are available for ambitious predoctoral and postdoctoral fellows interested in addressing fundamental questions in cell and developmental biology. Please send your research interest and CV to Takashi Hiiragi (t.hiiragi@hubrecht.eu).

Job openings

Technician

Research group

Hiiragi group

Start date

01/07/2022

Location

Utrecht Science Park

Vacancynumber

921