Tanenbaum: Gene expression dynamics

Back to research groups

The Tanenbaum group uses cutting-edge live-cell single molecule microscopy and new types of genetic engineering to study the molecular mechanisms of gene expression control in individual cells.

We aim to understand how regulation of gene expression affects important cell fate decisions. In addition, we are constantly developing and applying new imaging technologies to visualize gene expression dynamics with ever increasing resolution.

Key publications

Combined CRISPRi/a-based chemical genetic screens reveal that rigosertib is a microtubule-destabilizing agent.

Jost M, Chen Y*, Gilbert LA*, Horlbeck MA*, Krenning L*, Menchon G*, Rai A*, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME# and Weissman JS#.

Mol Cell 68(1):210-223.e6

Download|2017

# Corresponding authors

Dynamics of translation of single mRNA molecules in vivo.

Yan X, Hoek TA, Vale RD and Tanenbaum ME.

Cell; 165(4):976-89

Download|2016

Regulation of mRNA translation during mitosis.

Tanenbaum ME, Stern-Ginossar N, Weissman JS and Vale RD.

eLife 25;4

Download|2015

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes.

McKenney RJ, Huynh W, Tanenbaum ME, Bhabha G and Vale RD.

Science 345(6194):337-41

Download|2014

Cell 159:635–646

Download|2014

Group leader

Marvin Tanenbaum

Marvin Tanenbaum is group leader at the Hubrecht Institute. His group studies the molecular mechanisms of gene expression control at the single cell level and aims to understand how control of gene expression affects important cellular decisions. The Tanenbaum group has developed several new techniques, including the SunTag fluorescence imaging system. Using the SunTag system they can directly visualize and quantify translation of single mRNA molecules in living cells to study the dynamics and regulation of each individual mRNA in real time. In addition, the SunTag was re-purposed to create an artificial transcription factor to precisely modulate gene expression of endogenous genes.

Scientific training and positions

Awards


Group members

Marvin Tanenbaum

Principal Investigator

Ive Logister

Technician

Suzan Ruijtenberg

Postdoc

Deepak Khuperkar

Postdoc

Lenno Krenning

Postdoc

Tim Hoek

PhD Student

Stijn Sonneveld

PhD Student

Sanne Boersma

PhD Student

Bram Verhagen

PhD Student

Emmy Wesdorp

Student

Tonja Pavlovic

Student

Max Madern

Student

Lotte Burgering

MSc Student

Loes Steller

MSc Student

Maarten Dirkzwager

MSc Student

Lab alumni

Open positions for PhD students and Postdocs

Open positions for Master Students

Videos

Job openings

Postdoc

Research group

Tanenbaum group

Start date

Asap

Location

Utrecht Science Park

Period

Full time

PhD Student

Research group

Tanenbaum group

Start date

Asap

Location

Utrecht Science Park

Period

Full time