Tanenbaum: Gene expression dynamics

Back to research groups

The Tanenbaum group uses cutting-edge live-cell single molecule microscopy and new types of genetic engineering to uncover the molecular mechanisms of gene expression control in individual cells.

Our work focuses both on regulation of human genes in health and disease and on gene regulation of RNA viruses. Using our single-molecule approaches, we aim to uncover how the dynamics and heterogeneity in gene expression affects cell fate. In addition, we are developing new imaging technologies to visualize gene expression dynamics with ever increasing resolution to achieve a deep molecular understanding of these processes.

We are recruiting at multiple levels!!
–> More information at the bottom of this page

Key publications

Translation and Replication Dynamics of Single RNA Viruses

Boersma S, Rabouw HH, Bruurs LJM, [...] van Kuppeveld F*, Tanenbaum ME*

Cell: 183, 1–16

Download|2020

Single-molecule imaging uncovers rules governing nonsense-mediated mRNA decay

Hoek TA*, Khuperkar D*, Lindeboom RGH, [...] Tanenbaum ME

Molecular Cell 75(2):324-339

Download|2019

Multi-color single-molecule imaging uncovers extensive heterogeneity in mRNA decoding

Boersma S*, Khuperkar D*, Verhagen BMP, [...] Tanenbaum ME

Cell 178(2):458-472

Download|2019

Dynamics of translation of single mRNA molecules in vivo.

Yan X, Hoek TA, Vale RD and Tanenbaum ME.

Cell; 165(4):976-89

Download|2016

mRNA structural dynamics shape Argonaute-target interactions

Ruijtenberg S*, Sonneveld S*, Cui TJ, [...] Tanenbaum ME

Nat Struct Mol Biol. 28(6):533

Download|2020

A public-private partnership model for COVID-19 diagnostics

Krijger PHL*, Hoek TA*, [...] de Laat W#, Tanenbaum ME#

Nat Biotechnol. 39(10):1182-1184

Download|2021

Group leader

Marvin Tanenbaum

Marvin Tanenbaum is senior group leader at the Hubrecht Institute, Investigator at Oncode Institute and Professor in the department of Bionanoscience at the TU Delft. His group studies the molecular mechanisms of gene expression control at the single-molecule level, both for humans and in viruses, and aims to understand how control of gene expression affects important cellular decisions. The Tanenbaum group has developed several new techniques, including the SunTag fluorescence imaging system. They are using the SunTag system to visualize and quantify regulation of single mRNA molecules in living cells to study the dynamics and regulation of each individual mRNA in time and space. Adaptation of the SunTag imaging system to RNA viruses has enabled live observation of viral infection and gene expression regulation, which is uncovering exciting new mechanisms in viral infection and host response to replicating viruses. In addition to his research activities, Marvin has also co-developed a major new medical diagnostics platform which was widely used during the SARS-CoV-2 pandemic. Marvin also leads a new initiative at the Hubrecht Institute, the Hubrecht Talent Program (HTP), that aims to support minority students in science (see https://www.hubrecht.eu/about-us/hubrecht-talent-program/).

Scientific training and positions

Awards


Group members

Marvin Tanenbaum

Group Leader

Leonie Apperloo

Technician

Lucas Bruurs

Postdoc

Rupa Banerjee

Postdoc

Huib Rabouw

Postdoc

Dhanushika Ratnayake

Postdoc

Sora Yang

Postdoc

Jet Segeren

Postdoc

Bram Verhagen

PhD Student

Max Madern

PhD Student

Iris Bally

PhD Student

Micha Müller

PhD Student

Janin Schokolowski

PhD Student

Marloes van Drimmelen

MSc Student

Srinaath Narasimhan

MSc Student

Marijn Kansen

MSc Student

Amke Hackmann

MSc Student

Matthijs Baars

Researcher

Show all group members

Lab alumni

Open positions

Open positions for Master Students

Tools and reagents

Videos