Tanenbaum: Gene expression dynamics

Back to research groups

The Tanenbaum group uses cutting-edge live-cell single molecule microscopy and new types of genetic engineering to study the molecular mechanisms of gene expression control in individual cells.

We aim to understand how regulation of gene expression affects important cell fate decisions. In addition, we are constantly developing and applying new imaging technologies to visualize gene expression dynamics with ever increasing resolution.

Key publications

Single-molecule imaging uncovers rules governing nonsense-mediated mRNA decay

Hoek T.A.*, Khuperkar D.*, Lindeboom R.G.H., Sonneveld S., Verhagen B.M.P., Boersma S., Vermeulen M., and Tanenbaum M.E.

Molecular Cell 75, 1–16


Multi-color single-molecule imaging uncovers extensive heterogeneity in mRNA decoding

Boersma S*, Khuperkar D.*, Verhagen B.M.P., Sonneveld S, Grimm J.B., Lavis L.D. and Tanenbaum M.E.

Cell 178, 1–15


Combined CRISPRi/a-based chemical genetic screens reveal that rigosertib is a microtubule-destabilizing agent.

Jost M, Chen Y*, Gilbert LA*, Horlbeck MA*, Krenning L*, Menchon G*, Rai A*, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME# and Weissman JS#.

Mol Cell 68(1):210-223.e6


# Corresponding authors

Dynamics of translation of single mRNA molecules in vivo.

Yan X, Hoek TA, Vale RD and Tanenbaum ME.

Cell; 165(4):976-89


Regulation of mRNA translation during mitosis.

Tanenbaum ME, Stern-Ginossar N, Weissman JS and Vale RD.

eLife 25;4


Cell 159:635–646


Group leader

Marvin Tanenbaum

Marvin Tanenbaum is group leader at the Hubrecht Institute. His group studies the molecular mechanisms of gene expression control at the single cell level and aims to understand how control of gene expression affects important cellular decisions. The Tanenbaum group has developed several new techniques, including the SunTag fluorescence imaging system. Using the SunTag system they can directly visualize and quantify translation of single mRNA molecules in living cells to study the dynamics and regulation of each individual mRNA in real time. In addition, the SunTag was re-purposed to create an artificial transcription factor to precisely modulate gene expression of endogenous genes.

Scientific training and positions


Group members

Marvin Tanenbaum

Principal Investigator

Ive Logister


Suzan Ruijtenberg


Deepak Khuperkar


Lucas Bruurs


Rupa Banerjee


Huib Rabouw


Tim Hoek

PhD Student

Stijn Sonneveld

PhD Student

Sanne Boersma

PhD Student

Bram Verhagen

PhD Student

Max Madern

PhD Student

Iris Bally

PhD Student

Lab alumni

Open positions for PhD students and Postdocs

Open positions for Master Students