Tanenbaum: Gene expression dynamics

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The Tanenbaum group uses cutting-edge live-cell single molecule microscopy and new types of genetic engineering to study the molecular mechanisms of gene expression control in individual cells.

We aim to understand how regulation of gene expression affects important cell fate decisions. In addition, we are constantly developing and applying new imaging technologies to visualize gene expression dynamics with ever increasing resolution.

Key publications

Single-molecule imaging uncovers rules governing nonsense-mediated mRNA decay

Hoek TA*, Khuperkar D*, [...] Vermeulen M, and Tanenbaum ME

Molecular Cell 75(2):324-339


Multi-color single-molecule imaging uncovers extensive heterogeneity in mRNA decoding

Boersma S*, Khuperkar D*, [...] Lavis LD and Tanenbaum ME

Cell 178(2):458-472


Combined CRISPRi/a-based chemical genetic screens reveal that rigosertib is a microtubule-destabilizing agent.

Jost M, Chen Y*, Gilbert LA*, Horlbeck MA*, Krenning L*, Menchon G*, Rai A*, [...] Tanenbaum ME# and Weissman JS#.

Mol Cell 68(1):210-223


# Corresponding authors

Dynamics of translation of single mRNA molecules in vivo.

Yan X, Hoek TA, Vale RD and Tanenbaum ME.

Cell; 165(4):976-89


mRNA structural dynamics shape Argonaute-target interactions

Ruijtenberg S*, Sonneveld S*, [...] Joo C and Tanenbaum ME

Nat Struct Mol Biol. doi: 10.1038/s41594-020-0461-1


Cell 159(3):635-46


Group leader

Marvin Tanenbaum

Marvin Tanenbaum is group leader at the Hubrecht Institute. His group studies the molecular mechanisms of gene expression control at the single cell level and aims to understand how control of gene expression affects important cellular decisions. The Tanenbaum group has developed several new techniques, including the SunTag fluorescence imaging system. Using the SunTag system they can directly visualize and quantify translation of single mRNA molecules in living cells to study the dynamics and regulation of each individual mRNA in real time. In addition, the SunTag was re-purposed to create an artificial transcription factor to precisely modulate gene expression of endogenous genes.

Scientific training and positions


Group members

Marvin Tanenbaum

Group Leader

Ive Logister


Lucas Bruurs


Rupa Banerjee


Huib Rabouw


Dhanushika Ratnayake


Tim Hoek

PhD Student

Stijn Sonneveld

PhD Student

Sanne Boersma

PhD Student

Bram Verhagen

PhD Student

Max Madern

PhD Student

Iris Bally

PhD Student

Micha Müller

PhD Student

Elena Guido Vinzoni


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Lab alumni

Open positions for PhD students and Postdocs

Open positions for Master Students