Marvin Tanenbaum received his PhD in 2010 from Utrecht University (Cum Laude) for his work on cell division in the group of Prof. René Medema. During his PhD work, Marvin used live-cell microscopy to study the molecular mechanism of chromosome segregation during cell division, focusing on a small group of proteins called microtubule motor proteins. His thesis work was awarded the NVMO Oncology thesis award, and the Utrecht University Thesis Prize. After obtaining his PhD, he received KWF and EMBO fellowships to perform his postdoctoral research in the group of Prof. Ron Vale at UCSF in the United States. As a postdoc, Marvin developed a keen interest in studying the mechanisms and dynamics of gene expression control in single cells. He pioneered several new techniques, including the SunTag system, that enabled real-time observation of single protein molecules in action, and developed methods to observe gene expression in single living cells by fluorescence microscopy. He also developed a technique based on the SunTag system to modulate the transcriptional activity of individual genes in single cells. In 2015, he became a group leader at the Hubrecht Institute and was awarded an ERC Starting grant. His group uses cutting edge, single molecule microscopy and novel types of genetic engineering to dissect the temporal and spatial control of gene expression.
All the information to build a cell or organism is stored in our DNA. The process of translating this information to proteins is complex and highly regulated, allowing individual cells to precisely modulate gene expression to meet the constantly changing needs of the cell. We use high-resolution, single molecule microscopy and genetic engineering to study how individual cells dynamically tune gene expression. Our work focusses on (post-transcriptional) gene expression regulation during the cell cycle, and we aim to understand how control of protein levels affects key cell cycle decisions. Using live-cell microscopy, augmented by RNA sequencing and innovative types...
Yan X, Hoek TA, Vale RD and Tanenbaum ME. (2016). Dynamics of Translation of Single mRNA Molecules In Vivo. Cell. May 5;165(4):976-89 PDF
Tanenbaum ME, Stern-Ginossar N, Weissman JS and Vale RD. (2015). Regulation of mRNA translation during mitosis. eLife. 2015 Aug 25;4 PDF
Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS and Vale RD. (2014). A protein tagging system for signal amplification in gene transcription and fluorescence imaging. Cell. Oct. 23, 2014 PDF