Catherine Rabouille

Catherine Rabouille received her PhD in biochemistry in 1988, followed by postdoctoral experiences at the Joslin Diabetes Centre (Boston, MA), the UMC Utrecht (NL) and the Imperial Cancer Research Fund (London, UK) in the lab of Graham Warren where she started working on the Golgi and his fate during mitosis using electron microscopy. In 1998, she was the recipient of a Career Development Award from the Medical Research Council (UK) to set up her lab at the Wellcome trust Centre for Cell biology (Edinburgh, UK). There, she started her work on the functional organization of the early secretory pathway during Drosophila development. In 2002, she was offered an Associate professorship at the UMC Utrecht at the Department of Cell Biology where she continued her line of research focusing on Drosophila oogenesis as well as S2 cells. In 2010, she became a senior group leader at the Hubrecht Institute.


Team membersRabouille

Allesandro Gobino


Allesandro Gobino

Angelica Aquilera Gomez

PhD Student

Monique van der Voet


Monique van der Voet

Marinke van Oorschot


Catherine Rabouille

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Rabouille: The early secretory pathway under stress and during development

Regulation of secretion during development Delivery of newly synthesized proteins to the plasma membrane and the extracellular medium takes place in the membrane organelle of the secretory pathway. The molecular machinery behind the functional organization of this pathway is tightly controlled and is regulated by signaling. In this context, we study the role of ERK7 in Drosophila S2 cells. In addition to this classical secretion, a number of transmembrane proteins are unconventionally deposited to the plasma membrane, a pathway whose biogenesis is triggered by mechanical stress at specific stages of development. We study this unconventional secretion pathway in Drosophila as...

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Key publications

Zacharogianni, M., A. Aguilera, J. Smout, T. Veenendaal, and C. Rabouille (2014). A reversible non-membrane bound stress assembly that confers cell viability by preserving COPII components during amino-acid starvation. In revision at Elife.


Bellouze M, M.K. Schäfer, D. Buttigieg, G. Baillat, C. Rabouille and G. Haase (2014). Golgi fragmentation in pmn mice is due to a defective ARF1/TBCE cross talk that coordinates COPI vesicle formation and tubulin polymerization. Hum. Mol. Genet. Jun 20. pii: ddu320.


Giuliani, G., F. Giuliani, T. Volk and C. Rabouille (2013).The Drosophila RNA-binding protein HOW controls the stability of dgrasp mRNA in the follicular epithelium.
Nucleic Acids Res. 42(3):1970-86.


Weil, T.T., R.M. Parton, B. Herpers, J. Soetaert, T. Veenendaal, D. Xanthakis, I.M. Dobbie, J. Halstead, R. Hayashi, C. Rabouille* and I. Davis1* (2012). Drosophila patterning is established by differential association of mRNAs with P bodies. Nat. Cell Biol. 14:1305-13.


Zacharogianni, M., V. Kondylis, Y. Tang, D. Xanthakis, H. Farhan, F. Fuchs, M. Boutros and C. Rabouille (2011). ERK7 is a negative regulator of protein secretion in response to amino acid starvation by modulating Sec16 membrane association. EMBO J. 30:3684-700.

All publications

Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons
2016 in5700191214

SarahBellouze, GilbertBaillat, DorothéeButtigieg, Pierrede la Grange, CatherineRabouille, GeorgHaase

Localized Translation of gurken/TGF-α mRNA during Axis Specification Is Controlled by Access to Orb/CPEB on Processing Bodies
2016 in21100201068

AlexanderDavidson, Richard MParton, CatherineRabouille, Timothy TWeil, IlanDavis


CatherineRabouille, Adam DLinstedt

2016 in21100199812

CatherineRabouille, GeorgHaase

Pathways of Unconventional Protein Secretion
2016 in19066


In vivo vizualisation of mono-ADP-ribosylation by dPARP16 upon amino-acid starvation
2016 in21100242814

AngelicaAguilera-Gomez, Marinke Mvan Oorschot, TinekeVeenendaal, CatherineRabouille

On the shoulders of Hubrecht
2016 in14536

CatherineRabouille, JacquelineDeschamps

Loss of a Clueless-dGRASP complex results in ER stress and blocks Integrin exit from the perinuclear endoplasmic reticulum in Drosophila larval muscle
2015 in21100444312

Zong-HengWang, CatherineRabouille, Erika RGeisbrecht

SEC16 in COPII coat dynamics at ER exit sites
2015 in16855

JoepSprangers, CatherineRabouille

Innexin7a forms junctions that stabilize the basal membrane during cellularization of the blastoderm in Tribolium castaneum
2015 in14090

Maurijnvan der Zee, Matthew ABenton, TaniaVazquez-Faci, Gerda E MLamers, Chris G CJacobs, CatherineRabouille

TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules
2015 in18556

IrenaJevtov, MargaritaZacharogianni, Marinke Mvan Oorschot, Guusvan Zadelhoff, AngelicaAguilera-Gomez, IgorVuillez, InekeBraakman, ErnstHafen, HugoStocker, CatherineRabouille

Golgi Fragmentation in ALS Motor Neurons. New Mechanisms Targeting Microtubules, Tethers, and Transport Vesicles
2015 in21100199812

GeorgHaase, CatherineRabouille

The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima
2014 in12977

Ariel DChipman, David E KFerrier, CarloBrena, JiaxinQu, Daniel S THughes, ReinhardSchröder, MontserratTorres-Oliva, NadiaZnassi, HuaiyangJiang, Francisca CAlmeida, Claudio RAlonso, ZivkosApostolou, PeshtewaniAqrawi, WallaceArthur, Jennifer C JBarna, Kerstin PBlankenburg, DanielaBrites, SalvadorCapella-Gutiérrez, MarcusCoyle, Peter KDearden, LouisDu Pasquier, Elizabeth JDuncan, DieterEbert, CorneliusEibner, GalinaErikson, Peter DEvans, Cassandra GExtavour, LiezlFrancisco, ToniGabaldón, William JGillis, Elizabeth AGoodwin-Horn, Jack EGreen, SamGriffiths-Jones, Cornelis J PGrimmelikhuijzen, SaiGubbala, RodericGuigó, YiHan, FrankHauser, PaulHavlak, LukeHayden, SophieHelbing, MichaelHolder, Jerome H LHui, Julia PHunn, Vera SHunnekuhl, LaRondaJackson, MehwishJavaid, Shalini NJhangiani, Francis MJiggins, Tamsin EJones, Tobias SKaiser, DivyaKalra, Nathan JKenny, ViktoriyaKorchina, Christie LKovar, F BernhardKraus, FrançoisLapraz, Sandra LLee, JieLv, ChristigaleMandapat, GerardManning, MarcoMariotti, RobertMata, TittuMathew, TobiasNeumann, IreneNewsham, Dinh NNgo, MariaNinova, GeoffreyOkwuonu, FionaOngeri, William JPalmer, ShobhaPatil, PedroPatraquim, ChristopherPham, Ling-LingPu, Nicholas HPutman, CatherineRabouille, Olivia MendivilRamos, Adelaide CRhodes, Helen ERobertson, Hugh MRobertson, MatthewRonshaugen, JulioRozas, NehadSaada, AlejandroSánchez-Gracia, Steven EScherer, Andrew MSchurko, Kenneth WSiggens, DeNardSimmons, AnnaStief, EckartStolle, Maximilian JTelford, KristinTessmar-Raible, RebeccaThornton, Maurijnvan der Zee, Arndtvon Haeseler, James MWilliams, Judith HWillis, YuanqingWu, XiaoyanZou, DanielLawson, Donna MMuzny, Kim CWorley, Richard AGibbs, MichaelAkam, StephenRichards

Old dog, new tricks
2014 in17435


Golgi fragmentation in pmn mice is due to a defective ARF1/TBCE cross-talk that coordinates COPI vesicle formation and tubulin polymerization
2014 in22266

SarahBellouze, Michael KSchäfer, DorothéeButtigieg, GilbertBaillat, CatherineRabouille, GeorgHaase

Extracellular cleavage of E-cadherin promotes epithelial cell extrusion
2014 in18556

Adam GGrieve, CatherineRabouille

GRASP65 controls the cis Golgi integrity in vivo
2014 in21100444312

TinekeVeenendaal, TimJarvela, Adam GGrieve, Johan Hvan Es, Adam DLinstedt, CatherineRabouille

The Drosophila RNA-binding protein HOW controls the stability of dgrasp mRNA in the follicular epithelium
2014 in14204

GiulianoGiuliani, FabrizioGiuliani, TalilaVolk, CatherineRabouille

A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation
2014 in21100242814

MargaritaZacharogianni, Angelica AguileraGomez, TinekeVeenendaal, JanSmout, CatherineRabouille

The role of P125 at ERES

C.Rabouille, D.Klinkenberg