Catherine Rabouille

Catherine Rabouille received her PhD in biochemistry in 1988, followed by postdoctoral experiences at the Joslin Diabetes Centre (Boston, MA), the UMC Utrecht (NL) and the Imperial Cancer Research Fund (London, UK) in the lab of Graham Warren where she started working on the Golgi and his fate during mitosis using electron microscopy. In 1998, she was the recipient of a Career Development Award from the Medical Research Council (UK) to set up her lab at the Wellcome trust Centre for Cell biology (Edinburgh, UK). There, she started her work on the functional organization of the early secretory pathway during Drosophila development. In 2002, she was offered an Associate professorship at the UMC Utrecht at the Department of Cell Biology where she continued her line of research focusing on Drosophila oogenesis as well as S2 cells. In 2010, she became a senior group leader at the Hubrecht Institute.


Team members Rabouille

Catherine Rabouille


Angelica Aquilera Gomez

PhD Student

Angelica Aquilera Gomez

Monique van der Voet


Monique van der Voet

Marinke van Oorschot


Marinke van Oorschot

Allesandro Gobino


Allesandro Gobino

Show more

Show more


Rabouille_Sec bodies and SG in drosophila

Rabouille: The early secretory pathway under stress and during development

Regulation of secretion during development Delivery of newly synthesized proteins to the plasma membrane and the extracellular medium takes place in the membrane organelle of the secretory pathway. The molecular machinery behind the functional organization of this pathway is tightly controlled and is regulated by signaling. In this context, we study the role of ERK7 in Drosophila S2 cells. In addition to this classical secretion, a number of transmembrane proteins are unconventionally deposited to the plasma membrane, a pathway whose biogenesis is triggered by mechanical stress at specific stages of development. We study this unconventional secretion pathway in Drosophila as...

Read research

Key publications

Zacharogianni, M., A. Aguilera, J. Smout, T. Veenendaal, and C. Rabouille (2014). A reversible non-membrane bound stress assembly that confers cell viability by preserving COPII components during amino-acid starvation. In revision at Elife.


Bellouze M, M.K. Schäfer, D. Buttigieg, G. Baillat, C. Rabouille and G. Haase (2014). Golgi fragmentation in pmn mice is due to a defective ARF1/TBCE cross talk that coordinates COPI vesicle formation and tubulin polymerization. Hum. Mol. Genet. Jun 20. pii: ddu320.


Giuliani, G., F. Giuliani, T. Volk and C. Rabouille (2013).The Drosophila RNA-binding protein HOW controls the stability of dgrasp mRNA in the follicular epithelium.
Nucleic Acids Res. 42(3):1970-86.


Weil, T.T., R.M. Parton, B. Herpers, J. Soetaert, T. Veenendaal, D. Xanthakis, I.M. Dobbie, J. Halstead, R. Hayashi, C. Rabouille* and I. Davis1* (2012). Drosophila patterning is established by differential association of mRNAs with P bodies. Nat. Cell Biol. 14:1305-13.


Zacharogianni, M., V. Kondylis, Y. Tang, D. Xanthakis, H. Farhan, F. Fuchs, M. Boutros and C. Rabouille (2011). ERK7 is a negative regulator of protein secretion in response to amino acid starvation by modulating Sec16 membrane association. EMBO J. 30:3684-700.

All publications

Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons

Sarah Bellouze, Gilbert Baillat, Dorothée Buttigieg, Pierre de la Grange, Catherine Rabouille, Georg Haase

Localized Translation of gurken/TGF-α mRNA during Axis Specification Is Controlled by Access to Orb/CPEB on Processing Bodies
2016 in Cell Reports

Alexander Davidson, Richard M Parton, Catherine Rabouille, Timothy T Weil, Ilan Davis


Catherine Rabouille, Adam D Linstedt

Loss of a Clueless-dGRASP complex results in ER stress and blocks Integrin exit from the perinuclear endoplasmic reticulum in Drosophila larval muscle
2015 in Biology open

Zong-Heng Wang, Catherine Rabouille, Erika R Geisbrecht

SEC16 in COPII coat dynamics at ER exit sites
2015 in Biochemical Society Transactions

Joep Sprangers, Catherine Rabouille

Innexin7a forms junctions that stabilize the basal membrane during cellularization of the blastoderm in Tribolium castaneum
2015 in Development

Maurijn van der Zee, Matthew A Benton, Tania Vazquez-Faci, Gerda E M Lamers, Chris G C Jacobs, Catherine Rabouille

TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules
2015 in Journal of Cell Science

Irena Jevtov, Margarita Zacharogianni, Marinke M van Oorschot, Guus van Zadelhoff, Angelica Aguilera-Gomez, Igor Vuillez, Ineke Braakman, Ernst Hafen, Hugo Stocker, Catherine Rabouille

Golgi Fragmentation in ALS Motor Neurons. New Mechanisms Targeting Microtubules, Tethers, and Transport Vesicles
2015 in Frontiers in Neuroscience

Georg Haase, Catherine Rabouille

2015 in Frontiers in Neuroscience

Catherine Rabouille, Georg Haase

The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima
2014 in PLoS Biology

Ariel D Chipman, David E K Ferrier, Carlo Brena, Jiaxin Qu, Daniel S T Hughes, Reinhard Schröder, Montserrat Torres-Oliva, Nadia Znassi, Huaiyang Jiang, Francisca C Almeida, Claudio R Alonso, Zivkos Apostolou, Peshtewani Aqrawi, Wallace Arthur, Jennifer C J Barna, Kerstin P Blankenburg, Daniela Brites, Salvador Capella-Gutiérrez, Marcus Coyle, Peter K Dearden, Louis Du Pasquier, Elizabeth J Duncan, Dieter Ebert, Cornelius Eibner, Galina Erikson, Peter D Evans, Cassandra G Extavour, Liezl Francisco, Toni Gabaldón, William J Gillis, Elizabeth A Goodwin-Horn, Jack E Green, Sam Griffiths-Jones, Cornelis J P Grimmelikhuijzen, Sai Gubbala, Roderic Guigó, Yi Han, Frank Hauser, Paul Havlak, Luke Hayden, Sophie Helbing, Michael Holder, Jerome H L Hui, Julia P Hunn, Vera S Hunnekuhl, LaRonda Jackson, Mehwish Javaid, Shalini N Jhangiani, Francis M Jiggins, Tamsin E Jones, Tobias S Kaiser, Divya Kalra, Nathan J Kenny, Viktoriya Korchina, Christie L Kovar, F Bernhard Kraus, François Lapraz, Sandra L Lee, Jie Lv, Christigale Mandapat, Gerard Manning, Marco Mariotti, Robert Mata, Tittu Mathew, Tobias Neumann, Irene Newsham, Dinh N Ngo, Maria Ninova, Geoffrey Okwuonu, Fiona Ongeri, William J Palmer, Shobha Patil, Pedro Patraquim, Christopher Pham, Ling-Ling Pu, Nicholas H Putman, Catherine Rabouille, Olivia Mendivil Ramos, Adelaide C Rhodes, Helen E Robertson, Hugh M Robertson, Matthew Ronshaugen, Julio Rozas, Nehad Saada, Alejandro Sánchez-Gracia, Steven E Scherer, Andrew M Schurko, Kenneth W Siggens, DeNard Simmons, Anna Stief, Eckart Stolle, Maximilian J Telford, Kristin Tessmar-Raible, Rebecca Thornton, Maurijn van der Zee, Arndt von Haeseler, James M Williams, Judith H Willis, Yuanqing Wu, Xiaoyan Zou, Daniel Lawson, Donna M Muzny, Kim C Worley, Richard A Gibbs, Michael Akam, Stephen Richards

Old dog, new tricks
2014 in EMBO Journal

Catherine Rabouille

Golgi fragmentation in pmn mice is due to a defective ARF1/TBCE cross-talk that coordinates COPI vesicle formation and tubulin polymerization
2014 in Human Molecular Genetics

Sarah Bellouze, Michael K Schäfer, Dorothée Buttigieg, Gilbert Baillat, Catherine Rabouille, Georg Haase

Extracellular cleavage of E-cadherin promotes epithelial cell extrusion
2014 in Journal of Cell Science

Adam G Grieve, Catherine Rabouille

GRASP65 controls the cis Golgi integrity in vivo
2014 in Biology open

Tineke Veenendaal, Tim Jarvela, Adam G Grieve, Johan H van Es, Adam D Linstedt, Catherine Rabouille

The Drosophila RNA-binding protein HOW controls the stability of dgrasp mRNA in the follicular epithelium
2014 in Nucleic Acids Research

Giuliano Giuliani, Fabrizio Giuliani, Talila Volk, Catherine Rabouille

A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation

Margarita Zacharogianni, Angelica Aguilera Gomez, Tineke Veenendaal, Jan Smout, Catherine Rabouille

The role of P125 at ERES

C. Rabouille, D. Klinkenberg

Innexin 3, a new gene required for dorsal closure in Drosophila embryo
2013 in PLoS One

F. Giuliani, G. Giuliani, R. Bauer, C. Rabouille

Drosophila patterning is established by differential association of mRNAs with P bodies
2012 in Nature Cell Biology

T.T. Weil, R.M. Parton, B. Herpers, J. Soetaert, T. Veenendaal, D. Xanthakis, I.M. Dobbie, J.M. Halstead, R. Hayashi, C. Rabouille, I. Davis

Golgi bypass: skirting around the heart of classical secretion
2011 in Cold Spring Harbor Perspectives in Biology

A. Grieve, C. Rabouille