22 February 2017

Kees Jan Boogerd receives Marie Curie fellowship

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Kees Jan Boogerd form the Van Rooij group received a two year Marie Curie fellowship focused on Epigenetic Regulation of Cardiac Regeneration after Injury

Identifying the epigenetic mechanisms that control the cardiomyocyte cell cycle holds immense promise to accelerate our knowledge about the genes and pathways involved in cardiac maturation. This knowledge can be applied in efforts to impose a more cardio-regenerative gene program onto adult cardiomyocytes after injury, and could serve to identify potential targets for novel pharmacotherapies. In this grant we use state-of-the art genome wide epigenetics analysis and conditional mouse mutants to reveal the molecular pathways that regulate cardiomyocyte cell cycle withdrawal and most importantly, apply this knowledge to reverse clinical phenotypes after myocardial infarction (MI).