Catherine Rabouille

Catherine Rabouille received her PhD in biochemistry in 1988, followed by postdoctoral experiences at the Joslin Diabetes Centre (Boston, MA), the UMC Utrecht (NL) and the Imperial Cancer Research Fund (London, UK) in the lab of Graham Warren where she started working on the Golgi and his fate during mitosis using electron microscopy. In 1998, she was the recipient of a Career Development Award from the Medical Research Council (UK) to set up her lab at the Wellcome trust Centre for Cell biology (Edinburgh, UK). There, she started her work on the functional organization of the early secretory pathway during Drosophila development. In 2002, she was offered an Associate professorship at the UMC Utrecht at the Department of Cell Biology where she continued her line of research focusing on Drosophila oogenesis as well as S2 cells. In 2010, she became a senior group leader at the Hubrecht Institute.


Team membersRabouille groep

Amalia Marin Escobar

PhD Student

Wessel van Leeuwen

PhD Student

Rianne Grond


Allesandro Gobino


Allesandro Gobino

Monique van der Voet


Monique van der Voet

Marinke van Oorschot


Catherine Rabouille

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Rabouille: The early secretory pathway under stress and during development

Regulation of secretion during development Delivery of newly synthesized proteins to the plasma membrane and the extracellular medium takes place in the membrane organelle of the secretory pathway. The molecular machinery behind the functional organization of this pathway is tightly controlled and is regulated by signaling. In this context, we study the role of ERK7 in Drosophila S2 cells. In addition to this classical secretion, a number of transmembrane proteins are unconventionally deposited to the plasma membrane, a pathway whose biogenesis is triggered by mechanical stress at specific stages of development. We study this unconventional secretion pathway in Drosophila as...

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Key publications

Zacharogianni, M., A. Aguilera, J. Smout, T. Veenendaal, and C. Rabouille (2014). A reversible non-membrane bound stress assembly that confers cell viability by preserving COPII components during amino-acid starvation. In revision at Elife.


Bellouze M, M.K. Schäfer, D. Buttigieg, G. Baillat, C. Rabouille and G. Haase (2014). Golgi fragmentation in pmn mice is due to a defective ARF1/TBCE cross talk that coordinates COPI vesicle formation and tubulin polymerization. Hum. Mol. Genet. Jun 20. pii: ddu320.


Giuliani, G., F. Giuliani, T. Volk and C. Rabouille (2013).The Drosophila RNA-binding protein HOW controls the stability of dgrasp mRNA in the follicular epithelium.
Nucleic Acids Res. 42(3):1970-86.


Weil, T.T., R.M. Parton, B. Herpers, J. Soetaert, T. Veenendaal, D. Xanthakis, I.M. Dobbie, J. Halstead, R. Hayashi, C. Rabouille* and I. Davis1* (2012). Drosophila patterning is established by differential association of mRNAs with P bodies. Nat. Cell Biol. 14:1305-13.


Zacharogianni, M., V. Kondylis, Y. Tang, D. Xanthakis, H. Farhan, F. Fuchs, M. Boutros and C. Rabouille (2011). ERK7 is a negative regulator of protein secretion in response to amino acid starvation by modulating Sec16 membrane association. EMBO J. 30:3684-700.

All publications

The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima
2014 in12977

Ariel DChipman, David E KFerrier, CarloBrena, JiaxinQu, Daniel S THughes, ReinhardSchröder, MontserratTorres-Oliva, NadiaZnassi, HuaiyangJiang, Francisca CAlmeida, Claudio RAlonso, ZivkosApostolou, PeshtewaniAqrawi, WallaceArthur, Jennifer C JBarna, Kerstin PBlankenburg, DanielaBrites, SalvadorCapella-Gutiérrez, MarcusCoyle, Peter KDearden, LouisDu Pasquier, Elizabeth JDuncan, DieterEbert, CorneliusEibner, GalinaErikson, Peter DEvans, Cassandra GExtavour, LiezlFrancisco, ToniGabaldón, William JGillis, Elizabeth AGoodwin-Horn, Jack EGreen, SamGriffiths-Jones, Cornelis J PGrimmelikhuijzen, SaiGubbala, RodericGuigó, YiHan, FrankHauser, PaulHavlak, LukeHayden, SophieHelbing, MichaelHolder, Jerome H LHui, Julia PHunn, Vera SHunnekuhl, LaRondaJackson, MehwishJavaid, Shalini NJhangiani, Francis MJiggins, Tamsin EJones, Tobias SKaiser, DivyaKalra, Nathan JKenny, ViktoriyaKorchina, Christie LKovar, F BernhardKraus, FrançoisLapraz, Sandra LLee, JieLv, ChristigaleMandapat, GerardManning, MarcoMariotti, RobertMata, TittuMathew, TobiasNeumann, IreneNewsham, Dinh NNgo, MariaNinova, GeoffreyOkwuonu, FionaOngeri, William JPalmer, ShobhaPatil, PedroPatraquim, ChristopherPham, Ling-LingPu, Nicholas HPutman, CatherineRabouille, Olivia MendivilRamos, Adelaide CRhodes, Helen ERobertson, Hugh MRobertson, MatthewRonshaugen, JulioRozas, NehadSaada, AlejandroSánchez-Gracia, Steven EScherer, Andrew MSchurko, Kenneth WSiggens, DeNardSimmons, AnnaStief, EckartStolle, Maximilian JTelford, KristinTessmar-Raible, RebeccaThornton, Maurijnvan der Zee, Arndtvon Haeseler, James MWilliams, Judith HWillis, YuanqingWu, XiaoyanZou, DanielLawson, Donna MMuzny, Kim CWorley, Richard AGibbs, MichaelAkam, StephenRichards

Extracellular cleavage of E-cadherin promotes epithelial cell extrusion
2014 in18556

Adam GGrieve, CatherineRabouille

The Drosophila RNA-binding protein HOW controls the stability of dgrasp mRNA in the follicular epithelium
2014 in14204

GiulianoGiuliani, FabrizioGiuliani, TalilaVolk, CatherineRabouille

GRASP65 controls the cis Golgi integrity in vivo
2014 in21100444312

TinekeVeenendaal, TimJarvela, Adam GGrieve, Johan Hvan Es, Adam DLinstedt, CatherineRabouille

A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation
2014 in21100242814

MargaritaZacharogianni, Angelica AguileraGomez, TinekeVeenendaal, JanSmout, CatherineRabouille

The role of P125 at ERES

C.Rabouille, D.Klinkenberg

Innexin 3, a new gene required for dorsal closure in Drosophila embryo
2013 in10600153309

F.Giuliani, G.Giuliani, R.Bauer, C.Rabouille

Drosophila patterning is established by differential association of mRNAs with P bodies
2012 in19014

T.T.Weil, R.M.Parton, B.Herpers, J.Soetaert, T.Veenendaal, D.Xanthakis, I.M.Dobbie, J.M.Halstead, R.Hayashi, C.Rabouille, I.Davis

Golgi bypass: skirting around the heart of classical secretion
2011 in19700176402

A.Grieve, C.Rabouille

ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association
2011 in17435

M.Zacharogianni, V.Kondylis, Y.Tang, H.Farhan, D.Xanthakis, F.Fuchs, M.Boutros, C.Rabouille

Signalling to and from the secretory pathway
2011 in18556

H.Farhan, C.Rabouille

Identification of ER proteins involved in the functional organisation of the early secretory pathway in Drosophila cells by a targeted RNAi screen
2011 in10600153309

V.Kondylis, Y.Tang, F.Fuchs, M.Boutros, C.Rabouille

Unconventional secretion: a stress on GRASP
2011 in18797

F.Giuliani, A.Grieve, C.Rabouille

The multiple facets of the Golgi reassembly stacking proteins
2011 in16850

F.P.Vinke, A.Grieve, C.Rabouille