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The Garaycoechea group studies how the interaction between metabolism and DNA repair leads to mutation in a physiological setting.
DNA carries the instructions of life, but is also under constant attack. The resulting damage, if not repaired, leads to mutation and disease. Common environmental mutagens include sunlight and cigarette smoke, but the integrity of DNA is also threatened by chemicals produced by our own body. Our group wants to understand what are the metabolites that arise within cells that damage DNA, and the consequences of this damage. Particularly, we are interested in understanding the maintenance of genome stability in stem cells, the rare cell populations responsible for tissue maintenance.
Mulderrig L, Garaycoechea JI, Tuong ZK, Millington CL, Dingler FA, Ferdinand JR, Gaul L, Tadross JA, Arends MJ, O'Rahilly S, Crossan GP, Clatworthy MR, Patel KJ
Download|2021
Garaycoechea JI, Crossan GP, Langevin F, Mulderrig L, Louzada S, Yang F, Guilbaud G, Park N, Roerink S, Nik-Zainal S, Stratton MR, Patel KJ
Download|2018
Pontel LB, Rosado IV, Burgos-Barragan G, Garaycoechea JI, Yu R, Arends MJ, Chandrasekaran G, Broecker V, Wei W, Liu L, Swenberg JA, Crossan GP, Patel KJ
Download|2015
Garaycoechea JI, Crossan GP, Langevin F, Daly M, Arends MJ, Patel KJ
Download|2012
Mulderrig L, Garaycoechea JI
Download|2020
Luquette LJ, Miller MB, Zhou Z, Bohrson CL, Zhao Y, Jin H, Gulhan D, Ganz J, Bizzotto S, Kirkham S, Hochepied T, Libert C, Galor A, Kim J, Lodato MA, Garaycoechea JI, Gawad C, West J, Walsh CA, Park PJ
Download|2022
Juan Garaycoechea began his scientific career in Argentina, where in 2010 he obtained a first-class degree in Biotechnology from Universidad Nacional de Quilmes. He was then awarded the César Milstein scholarship to carry out his PhD studies at the MRC Laboratory of Molecular Biology (LMB), in Cambridge, UK. At the end of his studies, Juan was awarded a Junior Research Fellowship by King’s College, Cambridge to support his post-doctoral research at the LMB. He is a group leader at the Hubrecht Institute from October 2018, where he studies the metabolites that damage DNA and how this leads to mutation in a physiological context.
