Hematopoëse en stamcellen tijdens de embryonale ontwikkeling

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Key publications

Thambyrajah, R., Mazan, M., Patel, R., Moignard, V., Stefanska, M., Marinopoulou, E., Li, Y., Lancrin, C., Clapes, T., Möröy, T., Robin, C., Miller, C., Cowley, S., Göttgens, B., Kouskoff, V., Lacaud, G. GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1. Nature Cell Biology 18, 21-32 (2016)

Thambyrajah Nat Cell Biol 2016

 

Boisset, J.C., Clapes, T., Klaus, A., Papazian, N., Onderwater, J., Mommaas-Kienhuis, M., Cupedo, T., Robin, C. Progressive maturation toward hematopoietic stem cells in the mouse embryo aorta. Blood 125, 465-469 (2015)

Boisset 2015 Blood

Boisset, J.C., Andrieu-Soler, C., van Cappellen, W., Clapes, T., Robin, C. (2011) Ex vivo time-lapse confocal imaging of the mouse embryo aorta. Nature Protocols 6: 1792-1805.

Boisset Nat Prot 2011

 

Boisset, J.C., van Cappellen, W., Andrieu-Soler, C., Galjart, N., Dzierzak, E., Robin, C. (2010) In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature 464: 116-120.

Boisset nature 2010

 

Robin, C.*, Bollerot, K.*, Mendes, S.*, Haak, E., Crisan, M., Cerisoli, F., Lauw, I., Kaimakis, P., Jorna, R., Vermeulen, M., Kayser, M., van der Linden, R., Imanirad, P., Verstegen, M., Nawaz-Yousaf, M., Papazian, N., Steegers, E., Cupedo, T., Dzierzak, E. (2009) Human placenta is a potent hematopoietic niche containing hematopoietic stem and progenitor cells throughout development. Cell Stem Cell 5: 385-395.

Robin Cell stem cell 2009

 

Robin, C., Ottersbach, K., Durand, C., Peeters, M., Vanes, L., Tybulewicz, V., Dzierzak, E. (2006) An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells. Dev. Cell 11: 171-180.

Robin Dev cell 2006

 

de Bruijn, M.F.*, Ma, X.*, Robin, C.*, Ottersbach, K., Sanchez, M.J., Dzierzak, E. (2002) Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta. Immunity 16: 673-683

deBruijn Immunity 2002

All publications

PDFs are for personal use only.

2017

van den Brink, S.C., Sage, F., Vértesy, Á., Spanjaard, B., Peterson-Maduro, J., Baron, C.S., Robin, C., van Oudenaarden, A. (2017). Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations. Nat Methods 14, 935-936. https://www.hubrecht.eu/wp-content/uploads/2017/10/van-den-Brink-Nature-methods-2017.pdf

Yvernogeau, L., Robin, C. (2017). Restricted intra-embryonic origin of bona fide hematopoietic stem cells in the chicken. Development 144, 2352-2363. https://www.hubrecht.eu/wp-content/uploads/2017/10/Yvernogeau-Robin-Dev-2017.pdf

Klaus, A., Robin, C. (2017). Embryonic hematopoiesis under microscopic observation. Dev Biol. 428, 318-327. https://www.hubrecht.eu/wp-content/uploads/2017/10/Klaus-Robin-Dev-Biol-2017.pdf

 

2016

Thambyrajah, R., Mazan, M., Patel, R., Moignard, V., Stefanska, M., Marinopoulou, E., Li, Y., Lancrin, C., Clapes, T., Möröy, T., Robin, C., Miller, C., Cowley, S., Göttgens, B., Kouskoff, V., Lacaud, G. GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1. Nature Cell Biology 18, 21-32 (2016)

Thambyrajah Nat Cell Biol 2016

Robin C. (2016). Shedding light on hematopoietic stem cells: formation, regulation, and utilization. FEBS Lett. 590, 3963-3964. https://www.hubrecht.eu/wp-content/uploads/2017/10/Robin-2016-FEBS_Letters.pdf

2015

Heinig, K., Sage, F., Robin, C., Sperandio, M. Development and trafficking function of haematopoietic stem cells and myeloid cells during fetal ontogeny. Cardiovascular Research 107, 352-363 (2015)

Heinig Cardio research 2015

Yvernogeau, L., Boisset J.C., Robin, C. Developmental biology of hematopoietic stem cells: cellular aspects. Stem cell biology and regenerative medicine. River publishers. 301-326 (2015)

Boisset, J.C., Clapes, T., Klaus, A., Papazian, N., Onderwater, J., Mommaas-Kienhuis, M., Cupedo, T., Robin, C. Progressive maturation toward hematopoietic stem cells in the mouse embryo aorta. Blood 125, 465-469 (2015)

Boisset 2015 Blood

 

2013

Boisset, J.C., Clapes, T., Van Der Linden, R., Dzierzak, E., Robin, C. Integrin αIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta. Biology Open 2, 525-532 (2013)

Boisset Biol Open 2013

Bergink, S., Theil, A.F., Toussaint, W., De Cuyper, I.M., Kulu, D.I., Clapes, T., van der Linden, R., Demmers, J.A., Mul, E.P., van Alphen, F.P., Marteijn, J.A., van Gent, T., Maas, A., Robin, C., Philipsen, S., Vermeulen, W., Mitchell, J.R., Gutiérrez, L. Erythropoietic defect associated with reduced cell proliferation in mice lacking the 26S proteasome shuttling factor Rad23b. Molecular and Cellular Biology 33, 3879-3892 (2013)

Bergink Mol Cell Biol 2013

 

2012

Drabek, K., Gutiérrez, L., Vermeij, M., Clapes, T., Patel, SR., Boisset, JC., van Haren, J., Pereira, AL., Liu, Z., Akinci, U., Nikolic, T., van Ijcken, W., van den Hout, M., Meinders, M., Melo, C., Sambade, C., Drabek, D., Hendriks, RW., Philipsen, S., Mommaas, M., Grosveld, F., Maiato, H., Italiano, JE. Jr., Robin, C., Galjart, N. The microtubule Plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance. Cell Reports 2, 781-788 (2012)

Drabek + Suppl Cell reports 2012

Clapes, T. and Robin, C. Embryonic development of hematopoietic stem cells: implications for clinical use. Regenerative Medicine 7, 349-368 (2012)

Clapes reg med 2012

 

2011

Boisset, J.C., Andrieu-Soler, C., van Cappellen, W., Clapes, T., Robin, C. Ex vivo time-lapse confocal imaging of the mouse embryo aorta. Nature Protocols 6, 1792-1805 (2011)

Boisset Nat Prot 2011

Boisset, J.C., and Robin, C. Endothelial origin of hematopoietic stem cells: the proof in image | [Origine endothéliale des cellules souches hématopoïétiques: la preuve en image]. Médecine/Sciences 27, 875-81 (2011)

Boisset med sci 2011

Dzierzak, E., and Robin, C. Fast-forward: The fourth dimension in development. Development 138, 3-5 (2011)

Boisset, J.C., and Robin, C. On the origin of hematopoietic stem cells: Progress and controversy. Stem Cell Research 8, 1–13 (2011)

Boisset Stem cell research 2011

Robin, C.*, Ottersbach, K.*, Boisset, J.C., Oziemlak, A., Dzierzak, E. CD41 is developmentally regulated and differentially expressed on mouse hematopoietic stem cells. Blood 117, 5088-5091 (2011)

Robin Blood 2011

Staal, F.J., Baum, C., Cowan, C., Dzierzak, E., Hacein-Bey-Abina, S., Karlsson, S., Lapidot, T., Lemischka, I., Mendez-Ferrer, S., Mikkers, H., Moore, K., Moreno, E., Mummery, C.L., Robin, C., Suda, T., Van Pel, M., Vanden Brink, G., Zwaginga, J.J., Fibbe W.E. Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications. Leukemia 25, 1095-1102 (2011)

Staal Leukemia 2011

 

2010

Boisset, J.C., van Cappellen, W., Andrieu-Soler, C., Galjart, N., Dzierzak, E., Robin, C. In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature 464, 116-120 (2010)

Boisset nature 2010

Boisset, J.C., and Robin, C. Imaging the founder of adult hematopoiesis in the mouse embryo aorta. Cell Cycle 9, 2489-2490 (2010)

Boisset Cell cycle 2010

Dzierzak, E., and Robin, C. Placenta as a source of hematopoietic stem cells. Trends in Molecular Medicine 16, 361-367 (2010)

Dzierzak Trend in mol med 2010

Robin, C. and Durand, C. The roles of BMP and IL-3 signaling pathways in the control of hematopoietic stem cells in the mouse embryo. International Journal of Developmental Biology 54, 1189-1200 (2010)

Robin int J Dev Biol 2010

Robin, C., and Dzierzak, E. Preparation of hematopoietic stem and progenitor cells from the human placenta. Current Protocols Stem Cell Biology Chapter 2, Unit 2A 9 (2010)

 

2009

Robin, C.*, Bollerot, K.*, Mendes, S.*, Haak, E., Crisan, M., Cerisoli, F., Lauw, I., Kaimakis, P., Jorna, R., Vermeulen, M., Kayser, M., van der Linden, R., Imanirad, P., Verstegen, M., Nawaz-Yousaf, H., Papazian, N., Steegers, E., Cupedo, T., Dzierzak, E. Human placenta is a potent hematopoietic niche containing hematopoietic stem and progenitor cells throughout development. Cell Stem Cell 5, 385-395 (2009)

Robin Cell stem cell 2009

 

2008

Durand, C., Robin, C., Bollérot, K., Baron, M., Ottersbach, K., Dzierzak, E. The hematopoietic microenvironment of the AGM (Aorta-Gonads-Mesonephros) region: Molecular and cellular aspects | [Le microenvironnement hématopoïétique de la région AGM (Aorte-Gonade-Mésonephros): Aspects moléculaires et cellulaires]. Reproduction Humaine et Hormones 21, 246-250 (2008)

 

2007

Durand, C.*, Robin, C.*, Bollerot, K., Baron, M.H., Ottersbach, K., Dzierzak, E. Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells. Proceedings of the National Academy of Sciences U S A 104, 20838-20843 (2007)

Durand PNAS 2007

2006

Durand, C., Robin, C., Dzierzak, E. Mesenchymal lineage potentials of aorta-gonad-mesonephros stromal clones. Haematologica 91, 1172-1179 (2006)

Durand Haematologica 2006

Robin, C., Ottersbach, K., Durand, C., Peeters, M., Vanes, L., Tybulewicz, V., Dzierzak, E. An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells. Developmental Cell 11, 171-180 (2006)

Robin Dev cell 2006

 

 

2005

Mendes, S.C., Robin, C., Dzierzak, E. Mesenchymal progenitor cells localize within hematopoietic sites throughout ontogeny. Development 132, 1127-1136 (2005)

Mendes Dev 2005

Oostendorp, R.A., Robin, C., Steinhoff, C., Marz, S., Brauer, R., Nuber, U.A., Dzierzak, E.A., Peschel, C. Long-term maintenance of hematopoietic stem cells does not require contact with embryo-derived stromal cells in cocultures. Stem Cells 23, 842-851 (2005)

Oostendorp Stem cells 2005

Peeters, M., Ling, K.W., Oziemlak, A., Robin, C., Dzierzak, E. Multipotential hematopoietic progenitor cells from embryos developed in vitro engraft unconditioned W41/W41 neonatal miceB. Haematologica 90, 734-739 (2005)

Peeters Haematologica 2005

Robin, C., and Dzierzak, E. Hematopoietic stem cell enrichment from the AGM region of the mouse embryo. Methods in Molecular Medicine 105, 257-272 (2005)

 

2003

Robin, C., Ottersbach, K., de Bruijn, M., Ma, X., van der Horn, K., Dzierzak, E. Developmental origins of hematopoietic stem cells. Oncology Research 13, 315-321 (2003)

2002

Ma, X., de Bruijn, M., Robin, C., Peeters, M., Kong, A.S.J., de Wit, T., Snoijs, C., Dzierzak, E. Expression of the Ly-6A (Sca-1) lacZ transgene in mouse haematopoietic stem cells and embryos. British Journal of Haematology 116, 401-408 (2002)

Ma Br J Haematol 2002

Ma, X., Robin, C., Ottersbach, K., Dzierzak, E. The Ly-6A (Sca-1) GFP transgene is expressed in all adult mouse hematopoietic stem cells. Stem Cells 20, 514-521 (2002)

Ma Stem cell 2002

Ravet, E., Dubart-Kupperschmitt, A., Robin, C., Titeux, M., Coulombel, L., Pflumio, F. Successful transduction of human multipotent, lymphoid (T, B, NK) and myeloid, and transplantable CD34+CD38low cord blood cells using a murine oncoretroviral vector. Journal of Hematotherapy and Stem Cell Research 11, 327-336 (2002)

North, T.E., de Bruijn, M.F., Stacy, T., Talebian, L., Lind, E., Robin, C., Binder, M., Dzierzak, E., Speck, N.A. Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. Immunity 16, 661-672 (2002)

North Immunity 2002

de Bruijn, M.F.*, Ma, X.*, Robin, C.*, Ottersbach, K., Sanchez, M.J., Dzierzak, E. Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta. Immunity 16, 673-683 (2002)

deBruijn Immunity 2002

 

2001

Debili, N., Robin, C., Schiavon, V., Letestu, R., Pflumio, F., Mitjavila-Garcia, M.T., Coulombel, L., Vainchenker, W. Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates. Blood 97, 2023-2030 (2001)

Tavian, M., Robin, C., Coulombel, L., Peault, B. The human embryo, but not its yolk sac, generates lympho-myeloid stem cells: mapping multipotent hematopoietic cell fate in intraembryonic mesoderm. Immunity 15, 487-495 (2001)

Tavian Immunity 2001

 

2000

Tavian, M., Cortes, F., Robin, C., Schiavon, V., Hallais, M.F., Coulombel, L., Charbord, P., Labastie, M.C., Peault, B. [The hemangioblast, common precursor of endothelial and hematopoietic cells]; L’hemangioblaste, precurseur commun des cellules endotheliales et hematopoietiques. Transfusion Clinique et Biologique 7, 238-241 (2000)

 

1999

Robin, C., Bennaceur-Griscelli, A., Louache, F., Vainchenker, W., Coulombel, L. Identification of human T-lymphoid progenitor cells in CD34+CD38low and CD34+CD38+ subsets of human cord blood and bone marrow cells using NOD-SCID fetal thymus organ cultures. British Journal of Haematology 104, 809-819 (1999)

Robin, C., Pflumio, F., Vainchenker, W., Coulombel, L. Identification of lymphomyeloid primitive progenitor cells in fresh human cord blood and in the marrow of nonobese diabetic-severe combined immunodeficient (NOD-SCID) mice transplanted with human CD34+ cord blood cells. Journal of Experimental Medicine 189, 1601-1610 (1999)

Robin J Exp Med 1999

Pflumio, F., Tourino, C., Robin, C., Coulombel, L., Rouches, A., Ardouin, P. The NOD-SCID model to assess human hematopoietic stem cell function | [Transplantation de cellules hematopoietiques humaines in vivo III – Qu’attendre du module de transplantation par voie intraveineuse chez les souris NOD-SCID?]. Hematologie 5, 20-30 (1999)

 

1998

Carayol, G., Robin, C., Bourhis, J.H., Bennaceur-Griscelli, A., Chouaib, S., Coulombel, L., Caignard, A. NK cells differentiated from bone marrow, cord blood and peripheral blood stem cells exhibit similar phenotype and functions. European Journal of Immunology 28, 1991-2002 (1998)