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The Bartscherer group seeks to understand the mechanisms of successful tissue regeneration to promote this process in poorly regenerating mammals.
Injury is a severe threat to all animals. While some can fully restore lost body parts, others can only prevent further damage by mere wound healing, often associated with scar formation. Which molecular mechanisms determine whether regeneration is induced or not is a key question for regenerative medicine. Using different regenerative organisms, such as planarian flatworms and African spiny mice (Acomys) we aim at identifying the pathways to successful regeneration. We use comparative approaches between these animals and their poorly regenerating relatives to unveil, which roadblocks need to be overcome in order to promote regeneration. Our efforts also include tool development, such as transgenic methods, to further establish our favourite animals as regeneration models, and in vitro methods, such as organoid technology that will complement in vivo regeneration experiments.
Owlarn S, Schmidt D, Klenner F, Rabert F, Tomasso A, Vogg MC, Reuter H, Weidinger G, and Bartscherer K
Seebeck F, März M, Reuter H, Vogg MC, Mildner K, Zeuschner D, Rabert F, and Bartscherer K
Reuter H, März M, Vogg MC, Eccles D, Grifol-Boldu L, Owlarn S, Wehner D, Adell T, Weidinger G, and Bartscherer K
Böser A, Drexler HCA, Reuter H, Schmitz H, Wu G, Schöler HR, Gentile L, and Bartscherer K
März M, Seebeck F, and Bartscherer K
Bartscherer K, Pelte N, Ingelfinger D, and Boutros M
Owlarn S, and Bartscherer K
Vogg MC, Owlarn S, Perez Rico YA, Xie J, Suzuki Y, Gentile L, Wu W, and Bartscherer K
Hjeij R, Onoufriadis A, Watson CM, ..., Bartscherer K, Burdine RD, Lo CW, Omran H, Mitchison HM
Almuedo-Castillo M, Crespo X, Seebeck F, Bartscherer K, Salo E, Adell T
Sandmann T, Vogg MC, Owlarn S, Boutros M, and Bartscherer K (2011).
Gentile L, Cebrià F, and Bartscherer K
Buechling T, Bartscherer K, Ohkawara B, Chaudhary V, Spirohn K, Niehrs N, and Boutros M
Adell T, Saló E, Boutros M, and Bartscherer K
Davidson G, Shen J, Huang Y, Su Y, Karaulanov E, Bartscherer K, Hassler C, Stannek P, Boutros M, and Niehrs C
Bartscherer K, and Boutros M
Kerstin Bartscherer is a group leader at the Hubrecht Institute. Using both excellent invertebrate (planarian flatworms) and mammalian regenerators (African spiny mice) as experimental models, in combination with comparative approaches, the group aims to unveil the mechanisms that facilitate tissue regeneration. The ultimate goal is to utilize those mechanisms for promoting tissue regeneration in poorly regenerating mammals, such as normal mice, and eventually humans.
Scientific training and positions
Open positions for PhD students and Postdocs
We are currently recruiting highly motivated PhD students and postdocs for investigating the cellular and molecular mechanisms of regeneration using planarians and/or African spiny mice. Some projects involve RNAseq-based methods, such as single-cell RNAseq and Tomo-Seq; candidates should therefore have a background (or at least interest) in computational analysis methods. Other projects involve iPS technology and generation of organoids, as well as the establishment of transgenic methods for planarians and African spiny mice.
If you are interested in discussing available projects, please email Kerstin Bartscherer, including a CV and contact information for 2-3 references.