Rik Korswagen

Hendrik (Rik) Korswagen studied Medical Biology at Utrecht University. He received his PhD (cum laude) from the University of Amsterdam in 1999, based on research performed in the group of Ronald Plasterk at the Netherlands Cancer Institute. For this work he received the 1997 Antoni van Leeuwenhoek Award. He continued his postdoctoral research in the group of Hans Clevers at the University Medical Center in Utrecht. In 2000 he became a junior and in 2005 a senior group leader at the Hubrecht Institute, studying the mechanism and regulation of Wnt signaling. In 2013 he was appointed as a professor in Molecular Developmental Genetics at the Institute of Biodynamics and Biocomplexity of Utrecht University.

Other activities:

  • Professor at Utrecht University
  • Treasurer at the International Society for Developmental Biology
  • Member of the supervisory board at the University of Applied Sciences Utrecht

Team membersKorswagen

Christa van der Veen

PhD Student

Reinier van der Palen

Student

Reinier van der Palen

Shah Kishun

Student

Shah Kishun

Morgan Hoftijzer

Student

Morgan Hoftijzer

Sharon Christensen

Student

Sharon Christensen

Matilde Galli

Senior Postdoc

Matilde Galli

Luc Schoppink

Student

Luc Schoppink

Annabel Ebbing

PhD Student

Lorenzo Rella

PhD Student

Euclides Povoa

PhD Student

Marco Betist

Lab Assistant

Rik Korswagen

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Research

Korswagen: Mechanism of Wnt signaling in development and disease

Wnt proteins are members of an evolutionarily conserved family of signaling proteins with important functions in development, adult tissue homeostasis and disease. At the cellular level, Wnt proteins can trigger a wide variety of response, ranging from cell fate specification and proliferation to cell polarization and migration. We are studying the signaling mechanisms that mediate these different effects of Wnt.

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Key publications

Mentink, R.A., Middelkoop, T.C., Rella, L., Ji, N., van Oudenaarden, A., and Korswagen, H.C. (2014) Cell intrinsic modulation of Wnt signaling controls neuroblast migration in C. elegans. Developmental Cell 31: 188-201.

 

Ji, N., Middelkoop, T.C., Mentink, R.A., Betist, M.C., Tonegawa, S., Mooijman, D., Korswagen, H.C.* and van Oudenaarden, A* (2013) Feedback control of gene expression variability in the Caenorhabditis elegans Wnt pathway. Cell 155: 869-880. *Joint senior/corresponding authors. See also: Cell video abstract

 

Harterink, M., Port, F., Lorenowicz, M., McGough, I., Silhankova, M., Betist, M., van Weering, J., van Heesbeen, R., Middelkoop, T., Basler, K., Cullen, P., Korswagen, H.C. (2011) A SNX3-dependent Retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nature Cell Biology 13:914-923. See also:News & Views Highlight in EMBO J

 

Yang, P.T., Lorenowicz, M., Silhankova, M., Coudreuse, D.Y.M., Betist, M.C., Korswagen, H.C. (2008) Wnt signaling requires retromer dependent recycling of MIG-14/Wls in Wnt producing cells. Developmental Cell 14: 140-147.

 

Coudreuse, D.Y.M., Roel, G., Betist, M.C., Destree, O., Korswagen, H.C. (2006) Wnt gradient formation requires retromer function in Wnt producing cells. Science 312: 921-924.

 

Essers, M.A., de Vries-Smits, L.M.M., Barker, N., Polderman, P.E., Burgering, B.M.T., Korswagen, H.C. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308: 1181-1184.

All publications

A case of cross-reactivity
2011

H.C.Korswagen

Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells
2011

Y.Xiao, C.Bedet, V.J.Robert, T.Simonet, S.Dunkelbarger, C.Rakotomalala, G.Soete, H.C.Korswagen, S.Strome, F.Palladino

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion
2011

M.Harterink, F.Port, M.J.Lorenowicz, I.J.McGough, M.Silhankova, M.C.Betist, J.R.van Weering, R.G.van Heesbeen, T.C.Middelkoop, K.Basler, P.J.Cullen, H.C.Korswagen

Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein
2011

M.Harterink, D.H.Kim, T.C.Middelkoop, T.D.Doan, A.van Oudenaarden, H.C.Korswagen

Expression patterns of intronic microRNAs in Caenorhabditis elegans
2010

M.Isik, H.C.Korswagen, E.Berezikov

Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells
2010

M.Silhankova, F.Port, M.Harterink, K.Basler, H.C.Korswagen

The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network.
2009

T.Wassmer, N.Attar, M.Harterink, J.R.van Weering, C.J.Traer, J.Oakley, B.Goud, D.J.Stephens, P.Verkade, H.C.Korswagen, P.J.Cullen

Special Issue
2009

H.C.Korswagen

Sailing with the Wnt: charting the Wnt processing and secretion route
2009

M.J.Lorenowicz, H.C.Korswagen

Mammalian Wnt3a is released on lipoprotein particles
2009

S.Neumann, D.Y.M.Coudreuse, D.R.van der Westhuyzen, E.R.Eckhardt, H.C.Korswagen, G.Schmitz, H.Sprong

Phosphatidylinositol 3-kinase (PI3K) signaling does not activate the Wnt cascade
2009

S.S.Ng, T.Mahmoudi, E.M.Danenberg, I.Bejaoui, W.B.M.de Lau, H.C.Korswagen, M.Schutte, H.Clevers

Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells.
2008

P.T.Yang, M.J.Lorenowicz, M.Silhankova, D.Y.M.Coudreuse, M.C.Betist, H.C.Korswagen

Wnt activates the Tak1/Nlk kinase pathway
2004

L.Smit, A.Baas, J.Kuipers, H.Korswagen, M. van deWetering, J.C.Clevers

Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C
2003

A.M.van der Linden, C.Moorman, E.Cuppen, H.C.Korswagen, R.Plasterk

The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans
2002

H.C.Korswagen, D.Y.Coudreuse, M.C.Betist, S. van deWater, D.Zivkovic, J.C.Clevers

Activation and repression of wingless/Wnt target genes by the TCF/LEF-1 family of transcription factors
1999

H.C.Korswagen, J.C.Clevers