Kind: Developmental epigenomics

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The Kind group uses a combination of single-cell genomics and microscopy methods to study the role of chromatin and epigenetics in gene-regulation control, with a focus on early mouse embryonic development and tumorigenesis.

The aim of the lab is to understand the principles governing cellular decision-making. We are interested in how cells acquire new identities and traits in lineage specification events in mice and in cancer. To this end we employ and continuously develop novel single-cell technologies to delineate these processes with high sensitivity and accuracy.

Key words: Single-cell genomics, epigenetics, spatial genome organization, bioinformatics, gene-regulation, embryogenesis, tumorigenesis

Key publicationsView all publications

Nature Methods 21:72–82

Download|2023

Single-cell profiling of transcriptome and histone modifications with EpiDamID

Rang FJ, de Luca, KL, de Vries SS [...] Kimura H, Bakkers J and Kind J

Molecular Cell 82: 1-15

Download|2022

Nature Protocols 6:1922-1953.

Download|2020

Nature Biotechnology 37:766-772

Download|2019

Genome–lamina interactions are established de novo in the early mouse embryo

Borsos M, Perricone SM [...] Torres-Padilla M and Kind J

Nature 569: 429-433

Download|2019

Curr Opin Genet Dev 55:19-25

Download|2019

Genome-wide maps of nuclear lamina interactions in single human cells.

Kind J, Pagie L [...] van Oudenaarden A and van Steensel B

Cell 163: 134-147.

Download|2015

Single-cell dynamics of genome-nuclear lamina interactions.

Kind J, Pagie L [...] Bickmore WA and van Steensel B

Cell 153: 178-192.

Download|2013

Cell 133: 813-828.

Download|2008

Group leader

Jop Kind

Jop Kind is group leader at the Hubrecht Institute, professor by special appointment of Single Cell Epigenomics at the Radboud University Nijmegen and Oncode Investigator. His group is interested in elucidating the role of chromatin and nuclear architecture in gene-regulation and DNA-repair. The Kind group develops new techniques, such as the recently developed DamID and m6ATracer techniques. These techniques enable them to study genome architecture and protein-DNA interactions in high resolution in single cells. The Kind group uses these techniques to study the role of genome architecture and chromatin context in temporal and spatial control of gene expression in development and disease.

Scientific training and positions

Awards


Group members

Jop Kind

Group Leader

Sandra de Vries

Technician

Carla Kroon-Veenboer

Technician

Isabel Guerreiro

Postdoc

Christian Valdes

Postdoc

Robin van der Weide

Postdoc

Moritz Bauer

Postdoc

Isabel Sierra

Postdoc

Carlota Davo Martinez

Postdoc

Samy Kefalopoulou

PhD Student

Pim Rullens

PhD Student

Hidde Verhage

PhD Student

Marta Moreno Gonzalez

PhD Student

Lisa Sackmann

PhD Student

Vina My Pham

MSc Student

Kim de Luca

Guest

Franka Rang

Guest

Silke Lochs

Guest

Show all group members

We are always on the lookout for enthousiastic colleagues. If you are interested, please contact Jop Kind.