Matilde Galli

Matilde Galli is Hubrecht Fellow at the Hubrecht Institute. Her group aims to understand how cells know when and how to divide within a multicellular organism. They use genetic and cell biological approaches in C. elegans and mammalian systems to explore the establishment and function of various cell cycle programs. Of particular interest are cell cycles that lead to polyploidization, such as endoreplication and endomitosis, and how these cycles are regulated in normal physiology, such as during the development of the C. elegans intestine, as well as under pathological conditions, such as in cancer.

 

  • Hubrecht Fellow since 2017
  • Recipient of an HFSP Career Development Award in 2017
  • Recipient of a NWO Veni career grant in 2017
  • Independent researcher (2015-2017) within the group of Rik Korswagen at the Hubrecht Institute
  • Recipient of a Dutch Cancer Society (KWF) Fellowship for Basic Research in 2014
  • Recipient of a HFSP Postdoctoral Fellowship in 2012
  • Recipient of a NWO Rubicon Fellowship in 2012
  • Postdoc (2011-2015) in the group of David Morgan at the University of California San Francisco (UCSF), USA
  • Recipient of a PhD Fellowship from Boehringer Ingelheim Fonds in 2008
  • PhD (2007-2011) in the group of Sander van den Heuvel at the University of Utrecht, the Netherlands
[video src="https://www.hubrecht.eu/wp-content/uploads/2018/01/1-Embryo_control-1.mp4?controls=0&hd=1&autohide=1&title=0&byline=0&portrait=0" /]
[video src="https://www.hubrecht.eu/wp-content/uploads/2018/01/2-Embryo_Nocodazole-1.mp4?controls=0&hd=1&autohide=1&title=0&byline=0&portrait=0" /]
[video src="https://www.hubrecht.eu/wp-content/uploads/2018/01/3-Intestine_movie-1.mp4?controls=0&hd=1&autohide=1&title=0&byline=0&portrait=0" /]

Team membersGalli

Emma van Grinsven

Student

Emma van Grinsven

Lotte van Rijnberk

PhD Student

Lotte van Rijnberk

Reinier van der Palen

Technician

Reinier van der Palen

Mark van Leeuwen

Student

Mark van Leeuwen

Gabriella Darmasaputra

PhD Student

Gabriella Darmasaputra

Matilde Galli

Principal Investigator
m.galli@hubrecht.eu
http://www.gallilab.org

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Research

Galli: Cell cycle regulation

Galli: Cell cycle regulation

The Galli group studies the regulation of the cell cycle during development and tissue formation.

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Key publications

Cell Size Determines the Strength of the Spindle Assembly Checkpoint during Embryonic Development
M. Galli and D.O. Morgan
Dev Cell 36(3):344-352
2016

aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division
M. Galli, J. Muñoz, V. Portegijs, M. Boxem, S.W. Grill, A.J. Heck, S. van den Heuvel
Nat Cell Biol. 13(9):1132-1138
2011

Determination of the Cleavage Plane in Early C. elegans Embryos
M. Galli and S. van den Heuvel
Annual Review of Genetics 42:389-411
2008