Eelco de Koning

Eelco de Koning (1963) received his medical doctorate at the University of Utrecht, the Netherlands, in 1991. Subsequently, he moved to England and started research into islet biology and pathology at the Diabetes Research Laboratories in Oxford under supervison of Anne Clark and Robert Turner. He obtained a MRC Training Fellowship to finish these studies which resulted in a PhD thesis in 1994. In the same year he started his training in Internal Medicine followed by a fellowship in Endocrinology at the University Medical Center Utrecht (UMCU). He was board certified in endocrinology in 2001. He joined the research group of Ton Rabelink at the UMCU focusing on complications in diabetes mellitus. In 2004 this group moved to the Leiden University Medical Center (LUMC). In addition, in 2004 a Career Development Grant awarded by the Dutch Diabetes Research Foundation and a fellowship from the Joslin Diabetes Center (Harvard Medical School) in Boston laid the foundations of his current clinical and research activities. From 2004-2005 he joined the groups of Susan Bonner-Weir and Gordon Weir at the Department of Islet Transplantation and Cell Biology (Joslin Diabetes Center). In their groups he participated in the clinical human islet isolation and transplantation program and in islet progenitor cell research. In 2006 he returned to the LUMC to establish a laboratory for human islet isolation under GMP conditions and to direct the clinical islet transplantation program in the Netherlands. This program is operational since 2007. In 2010 he also joined the Hubrecht Institute focusing on islet progenitor cell research. Using a bench-to-bedside approach he has initiated and heads multicenter research programs on improvement of islet transplantation and use of islet progenitor cells for beta-cell therapy. He was appointed professor of diabetology at the University of Leiden in 2011.

e.koning(at)hubrecht.eu

Team membersde Koning

Cindy Loomans

Guest

Cindy Loomans

Bernard van den Berg

Guest

Bernard van den Berg

Ton Rabelink

Guest

Ton Rabelink

Antonius de Waard

Student

Antonius de Waard

Nerys Williams

PhD Student

Nerys Williams

Gitanjali Dharmadhikarn

Postdoc

Erik Jansen

Technician

Erik Jansen

Léon van Gurp

Technician

Eelco de Koning

Show more

Show more

Research

De Koning: Diabetes and islet neogenesis

Replacement of the insulin-producing beta cells in the islets of Langerhans in the pancreas is the only option to restore normoglycemia without an increased risk of hypoglycemia in patients with type 1 diabetes. Currently we can perform this therapy in a small group of patients by pancreas or islet transplantation. But a shortage of donor organs limits the wider application of beta-cell replacement therapy. Therefore, alternative cell sources are necessary to generate sufficient beta-cells for future therapy. In collaboration with the Leiden University Medical Center we explore the use of human pancreatic progenitor cells to reach this goal....

Read research

All publications

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
2016 in6100153018

DominicGrün, Mauro JMuraro, Jean-CharlesBoisset, KayWiebrands, AnnaLyubimova, GitanjaliDharmadhikari, Maaikevan den Born, Johanvan Es, ErikJansen, HansClevers, Eelco J Pde Koning, Alexandervan Oudenaarden

Selection of polymers for application in scaffolds applicable for human pancreatic islet transplantation
2016

Alexandra MSmink, Bart Jde Haan, Genaro AParedes-Juarez, Anouk H GWolters, JeroenKuipers, Ben N GGiepmans, LeendertSchwab, Marten AEngelse, Aart Avan Apeldoorn, Eelcode Koning, Marijke MFaas, Paulde Vos

Hybrid Polycaprolactone/Alginate Scaffolds Functionalized with VEGF to Promote de Novo Vessel Formation for the Transplantation of Islets of Langerhans
2016

GiuliaMarchioli, Andrea DiLuca, Eelcode Koning, MartenEngelse, Clemens AVan Blitterswijk, MarcelKarperien, Aart AVan Apeldoorn, LorenzoMoroni

Coculturing Human Islets with Proangiogenic Support Cells to Improve Islet Revascularization at the Subcutaneous Transplantation Site
2016

MijkeBuitinga, KarolinaJaneczek Portalska, Dirk-JanCornelissen, JacquelinePlass, MaaikeHanegraaf, FrançoiseCarlotti, Eelcode Koning, MartenEngelse, Clemensvan Blitterswijk, MarcelKarperien, Aartvan Apeldoorn, Jande Boer

Incidence and prevalence of thyroid dysfunction in type 1 diabetes
2016

ChristaNederstigt, Eleonora P MCorssmit, Eelco J Pde Koning, Olaf MDekkers

Human islets and dendritic cells generate post-translationally modified islet auto-antigens
2016 in20734

Rene JMcLaughlin, Annede Haan, ArnaudZaldumbide, Eelco Jde Koning, Arnoud Hde Ru, Peter Avan Veelen, Mennovan Lummel, Bart ORoep

Simultaneous pancreas-kidney transplantation in patients with type 1 diabetes reverses elevated MBL levels in association with MBL2 genotype and VEGF expression
2016 in25584

RoelBijkerk, Pietervan der Pol, MeriemKhairoun, Danielle Jvan Gijlswijk-Jansen, EllenLievers, Aiko P Jde Vries, Eelco Jde Koning, Hans Wde Fijter, Dave LRoelen, Rolf H A MVossen, Anton Janvan Zonneveld, Ceesvan Kooten, Marlies E JReinders

Sequential intravital imaging reveals in vivo dynamics of pancreatic tissue transplanted under the kidney capsule in mice
2016 in25584

Léonvan Gurp, Cindy J MLoomans, Pim Pvan Krieken, GitanjaliDharmadhikari, ErikJansen, Femke C A SRingnalda, EvelyneBeerling, Jaccovan Rheenen, Eelco J Pde Koning

A Retrievable, Efficacious Polymeric Scaffold for Subcutaneous Transplantation of Rat Pancreatic Islets
2016 in21721

Alexandra MSmink, Don THertsig, LeendertSchwab, Aart Avan Apeldoorn, Eelcode Koning, Marijke MFaas, Bart Jde Haan, Paulde Vos

A Single-Cell Transcriptome Atlas of the Human Pancreas
2016

Mauro JMuraro, GitanjaliDharmadhikari, DominicGrün, NathalieGroen, TimDielen, ErikJansen, Leonvan Gurp, Marten AEngelse, FrancoiseCarlotti, Eelco J Pde Koning, Alexandervan Oudenaarden

Targeting development of incretin-producing cells increases insulin secretion
2015 in15870

NataliaPetersen, FrankReimann, Johan Hvan Es, Bernard Mvan den Berg, ChantalKroone, RamonaPais, ErikJansen, HansClevers, Fiona MGribble, Eelco J Pde Koning

Loss of β-cell identity occurs in type 2 diabetes and is associated with islet amyloid deposits
2015 in25487

H SiebeSpijker, HeeinSong, Johanne HEllenbroek, Maaike MRoefs, Marten AEngelse, ErikBos, Abraham JKoster, Ton JRabelink, Barbara CHansen, AnneClark, FrançoiseCarlotti, Eelco J Pde Koning

Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets
2015 in15852

JannekeHilderink, SiebeSpijker, FrançoiseCarlotti, LydiaLange, MartenEngelse, Clemensvan Blitterswijk, Eelcode Koning, MarcelKarperien, Aartvan Apeldoorn

Thirty Years of Pancreas Transplantation at Leiden University Medical Center
2015 inCell Transplantation

Wouter HKopp, Merel J JVerhagen, Joris JBlok, Volkert A LHuurman, Johan Wde Fijter, Eelco Jde Koning, HeinPutter, Andzrej GBaranski, Alexander F MSchaapherder, Andries EBraat, JanRingers

Structure-guided design of selective Epac1 and Epac2 agonists
2015 in12977

FrankSchwede, DanielaBertinetti, Carianne NLangerijs, Michael AHadders, HansWienk, Johanne HEllenbroek, Eelco J Pde Koning, Johannes LBos, Friedrich WHerberg, Hans-GottfriedGenieser, Richard A JJanssen, HolgerRehmann

Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97
2015 in10600153309

HannekeHoelen, ArnaudZaldumbide, Wouter Fvan Leeuwen, Ellen C WTorfs, Marten AEngelse, ChopieHassan, Robert JanLebbink, Eelco Jde Koning, Maaike EResssing, Arnoud Hde Ru, Peter Avan Veelen, Rob CHoeben, Bart ORoep, Emmanuel J H JWiertz

KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas
2015 in21100248838

Matthias SRoost, Liesbethvan Iperen, YavuzAriyurek, Henk PBuermans, WibowoArindrarto, Harsha DDevalla, RobertPassier, Christine LMummery, FrançoiseCarlotti, Eelco J Pde Koning, Erik Wvan Zwet, Jelle JGoeman, Susana MChuva de Sousa Lopes

DNA Methylation Landscapes of Human Fetal Development
2015 in4000151808

Roderick CSlieker, Matthias SRoost, Liesbethvan Iperen, H Eka DSuchiman, Elmar WTobi, FrançoiseCarlotti, Eelco J Pde Koning, P ElineSlagboom, Bastiaan THeijmans, Susana MChuva de Sousa Lopes

DAMP production by human islets under low oxygen and nutrients in the presence or absence of an immunoisolating-capsule and necrostatin-1
2015 in21100200805

Genaro AParedes-Juarez, Neha MSahasrabudhe, Reina STjoelker, Bart Jde Haan, Marten AEngelse, Eelco J Pde Koning, Marijke MFaas, Paulde Vos

Erfelijke ouderdomsdiabetes bij jongeren
2015 in15828

Karinvan der Tuin, Sabine EHannema, E C A M MiekeHoudijk, MoniqueLosekoot, Eelco J Pde Koning, Martijn HBreuning