Eelco de Koning

Eelco de Koning (1963) received his medical doctorate at the University of Utrecht, the Netherlands, in 1991. Subsequently, he moved to England and started research into islet biology and pathology at the Diabetes Research Laboratories in Oxford under supervison of Anne Clark and Robert Turner. He obtained a MRC Training Fellowship to finish these studies which resulted in a PhD thesis in 1994. In the same year he started his training in Internal Medicine followed by a fellowship in Endocrinology at the University Medical Center Utrecht (UMCU). He was board certified in endocrinology in 2001. He joined the research group of Ton Rabelink at the UMCU focusing on complications in diabetes mellitus. In 2004 this group moved to the Leiden University Medical Center (LUMC). In addition, in 2004 a Career Development Grant awarded by the Dutch Diabetes Research Foundation and a fellowship from the Joslin Diabetes Center (Harvard Medical School) in Boston laid the foundations of his current clinical and research activities. From 2004-2005 he joined the groups of Susan Bonner-Weir and Gordon Weir at the Department of Islet Transplantation and Cell Biology (Joslin Diabetes Center). In their groups he participated in the clinical human islet isolation and transplantation program and in islet progenitor cell research. In 2006 he returned to the LUMC to establish a laboratory for human islet isolation under GMP conditions and to direct the clinical islet transplantation program in the Netherlands. This program is operational since 2007. In 2010 he also joined the Hubrecht Institute focusing on islet progenitor cell research. Using a bench-to-bedside approach he has initiated and heads multicenter research programs on improvement of islet transplantation and use of islet progenitor cells for beta-cell therapy. He was appointed professor of diabetology at the University of Leiden in 2011.

e.koning(at)hubrecht.eu

Team members de Koning

Erik Jansen

Technician

Erik Jansen

Eelco de Koning

Gitanjali Dharmadhikarn

Postdoc

Ton Rabelink

Guest

Ton Rabelink

Antonius de Waard

Student

Antonius de Waard

Léon van Gurp

Technician

Nerys Williams

PhD Student

Nerys Williams

Cindy Loomans

Guest

Cindy Loomans

Bernard van den Berg

Guest

Bernard van den Berg

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Research

De Koning: Diabetes and islet neogenesis

Replacement of the insulin-producing beta cells in the islets of Langerhans in the pancreas is the only option to restore normoglycemia without an increased risk of hypoglycemia in patients with type 1 diabetes. Currently we can perform this therapy in a small group of patients by pancreas or islet transplantation. But a shortage of donor organs limits the wider application of beta-cell replacement therapy. Therefore, alternative cell sources are necessary to generate sufficient beta-cells for future therapy. In collaboration with the Leiden University Medical Center we explore the use of human pancreatic progenitor cells to reach this goal....

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All publications

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
2016 in 6100153018

Dominic Grün, Mauro J Muraro, Jean-Charles Boisset, Kay Wiebrands, Anna Lyubimova, Gitanjali Dharmadhikari, Maaike van den Born, Johan van Es, Erik Jansen, Hans Clevers, Eelco J P de Koning, Alexander van Oudenaarden

Selection of polymers for application in scaffolds applicable for human pancreatic islet transplantation
2016

Alexandra M Smink, Bart J de Haan, Genaro A Paredes-Juarez, Anouk H G Wolters, Jeroen Kuipers, Ben N G Giepmans, Leendert Schwab, Marten A Engelse, Aart A van Apeldoorn, Eelco de Koning, Marijke M Faas, Paul de Vos

Hybrid Polycaprolactone/Alginate Scaffolds Functionalized with VEGF to Promote de Novo Vessel Formation for the Transplantation of Islets of Langerhans
2016

Giulia Marchioli, Andrea Di Luca, Eelco de Koning, Marten Engelse, Clemens A Van Blitterswijk, Marcel Karperien, Aart A Van Apeldoorn, Lorenzo Moroni

Coculturing Human Islets with Proangiogenic Support Cells to Improve Islet Revascularization at the Subcutaneous Transplantation Site
2016

Mijke Buitinga, Karolina Janeczek Portalska, Dirk-Jan Cornelissen, Jacqueline Plass, Maaike Hanegraaf, Françoise Carlotti, Eelco de Koning, Marten Engelse, Clemens van Blitterswijk, Marcel Karperien, Aart van Apeldoorn, Jan de Boer

Incidence and prevalence of thyroid dysfunction in type 1 diabetes
2016

Christa Nederstigt, Eleonora P M Corssmit, Eelco J P de Koning, Olaf M Dekkers

Human islets and dendritic cells generate post-translationally modified islet auto-antigens
2016 in 20734

Rene J McLaughlin, Anne de Haan, Arnaud Zaldumbide, Eelco J de Koning, Arnoud H de Ru, Peter A van Veelen, Menno van Lummel, Bart O Roep

Simultaneous pancreas-kidney transplantation in patients with type 1 diabetes reverses elevated MBL levels in association with MBL2 genotype and VEGF expression
2016 in 25584

Roel Bijkerk, Pieter van der Pol, Meriem Khairoun, Danielle J van Gijlswijk-Jansen, Ellen Lievers, Aiko P J de Vries, Eelco J de Koning, Hans W de Fijter, Dave L Roelen, Rolf H A M Vossen, Anton Jan van Zonneveld, Cees van Kooten, Marlies E J Reinders

Sequential intravital imaging reveals in vivo dynamics of pancreatic tissue transplanted under the kidney capsule in mice
2016 in 25584

Léon van Gurp, Cindy J M Loomans, Pim P van Krieken, Gitanjali Dharmadhikari, Erik Jansen, Femke C A S Ringnalda, Evelyne Beerling, Jacco van Rheenen, Eelco J P de Koning

A Retrievable, Efficacious Polymeric Scaffold for Subcutaneous Transplantation of Rat Pancreatic Islets
2016 in 21721

Alexandra M Smink, Don T Hertsig, Leendert Schwab, Aart A van Apeldoorn, Eelco de Koning, Marijke M Faas, Bart J de Haan, Paul de Vos

A Single-Cell Transcriptome Atlas of the Human Pancreas
2016

Mauro J Muraro, Gitanjali Dharmadhikari, Dominic Grün, Nathalie Groen, Tim Dielen, Erik Jansen, Leon van Gurp, Marten A Engelse, Francoise Carlotti, Eelco J P de Koning, Alexander van Oudenaarden

Targeting development of incretin-producing cells increases insulin secretion
2015 in 15870

Natalia Petersen, Frank Reimann, Johan H van Es, Bernard M van den Berg, Chantal Kroone, Ramona Pais, Erik Jansen, Hans Clevers, Fiona M Gribble, Eelco J P de Koning

Loss of β-cell identity occurs in type 2 diabetes and is associated with islet amyloid deposits
2015 in 25487

H Siebe Spijker, Heein Song, Johanne H Ellenbroek, Maaike M Roefs, Marten A Engelse, Erik Bos, Abraham J Koster, Ton J Rabelink, Barbara C Hansen, Anne Clark, Françoise Carlotti, Eelco J P de Koning

Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets
2015 in 15852

Janneke Hilderink, Siebe Spijker, Françoise Carlotti, Lydia Lange, Marten Engelse, Clemens van Blitterswijk, Eelco de Koning, Marcel Karperien, Aart van Apeldoorn

Thirty Years of Pancreas Transplantation at Leiden University Medical Center
2015 in Cell Transplantation

Wouter H Kopp, Merel J J Verhagen, Joris J Blok, Volkert A L Huurman, Johan W de Fijter, Eelco J de Koning, Hein Putter, Andzrej G Baranski, Alexander F M Schaapherder, Andries E Braat, Jan Ringers

Structure-guided design of selective Epac1 and Epac2 agonists
2015 in 12977

Frank Schwede, Daniela Bertinetti, Carianne N Langerijs, Michael A Hadders, Hans Wienk, Johanne H Ellenbroek, Eelco J P de Koning, Johannes L Bos, Friedrich W Herberg, Hans-Gottfried Genieser, Richard A J Janssen, Holger Rehmann

Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97
2015 in 10600153309

Hanneke Hoelen, Arnaud Zaldumbide, Wouter F van Leeuwen, Ellen C W Torfs, Marten A Engelse, Chopie Hassan, Robert Jan Lebbink, Eelco J de Koning, Maaike E Resssing, Arnoud H de Ru, Peter A van Veelen, Rob C Hoeben, Bart O Roep, Emmanuel J H J Wiertz

KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas
2015 in 21100248838

Matthias S Roost, Liesbeth van Iperen, Yavuz Ariyurek, Henk P Buermans, Wibowo Arindrarto, Harsha D Devalla, Robert Passier, Christine L Mummery, Françoise Carlotti, Eelco J P de Koning, Erik W van Zwet, Jelle J Goeman, Susana M Chuva de Sousa Lopes

DNA Methylation Landscapes of Human Fetal Development
2015 in 4000151808

Roderick C Slieker, Matthias S Roost, Liesbeth van Iperen, H Eka D Suchiman, Elmar W Tobi, Françoise Carlotti, Eelco J P de Koning, P Eline Slagboom, Bastiaan T Heijmans, Susana M Chuva de Sousa Lopes

DAMP production by human islets under low oxygen and nutrients in the presence or absence of an immunoisolating-capsule and necrostatin-1
2015 in 21100200805

Genaro A Paredes-Juarez, Neha M Sahasrabudhe, Reina S Tjoelker, Bart J de Haan, Marten A Engelse, Eelco J P de Koning, Marijke M Faas, Paul de Vos

Erfelijke ouderdomsdiabetes bij jongeren
2015 in 15828

Karin van der Tuin, Sabine E Hannema, E C A M Mieke Houdijk, Monique Losekoot, Eelco J P de Koning, Martijn H Breuning