Team membersvan Rheenen groep

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Key publications

Zomer A, Maynard C, Verweij FJ, Kamermans A, Schäfer R, Beerling E, Schiffelers RM, de Wit E, Berenguer J, Ellenbroek SIJ, Wurdinger T, Pegtel DM, van Rheenen J, (2015), In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior. Cell, 161(5):1046–1057 Zomer_et_al_extended pdf

 

Ellenbroek SI, van Rheenen J. (2014) Imaging hallmarks of cancer in living mice. Nature Reviews Cancer, 14(6): 406-18

 

Ritsma L*, Ellenbroek SI*, Zomer A, Snippert HJ, de Sauvage FJ, Simons BD, Clevers H, van Rheenen J, (2014) Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature, 507(7492): 362-5

 

Ritsma L, Vrisekoop N, van Rheenen (2013) In vivo imaging and histochemistry are combined in the cryosection labelling and intravital microscopy technique. Nat Commun., 4:2366

 

Ritsma, L.*, Steller, E.J.A.*, Beerling, E., Loomans, C.J.M., Zomer, A., Gerlach, C., Vrisekoop, N., Seinstra, D., van Gurp, L., Schäfer, R., Raats, D.A., de Graaff, A. Schumacher, T.N., de Koning, E.J.P. Borel Rinkes, I.H., Kranenburg, O. van Rheenen, J. (2012) Intravital Microscopy Through an Abdominal Imaging Window Reveals a Pre-Micrometastasis Stage During Liver Metastasis. Sci Transl Med 4, 158ra145.

 

Jalink K, van Rheenen, J (2010) Nano-imaging of membrane topography affects interpretations in cell biology. Nat. Meth. 7:486.

 

Snippert HJ, van der Vlier LG, Sato T, van Es JH, van der Born M, Kroen-Veenboer C, Barker N, Klein AM, van Rheenen J, Simons BD, Clevers H. (2010) Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells, Cell, 143(1): 134-144.

All publications

Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases
2016

SophiaFrentzas, EveSimoneau, Victoria LBridgeman, Peter BVermeulen, ShaneFoo, EleftheriosKostaras, Mark RNathan, AndrewWotherspoon, Zu-HuaGao, YuShi, GertVan den Eynden, FrancesDaley, ClarePeckitt, XianmingTan, AyatSalman, AnthoulaLazaris, PatrycjaGazinska, Tracy JBerg, ZakEltahir, LailaRitsma, Jaccovan Rheenen, AllaKhashper, GinaBrown, HannaNyström, MalinSund, StevenVan Laere, EvelyneLoyer, LucDirix, DavidCunningham, PeterMetrakos, Andrew RReynolds

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon
2016

NobuoSasaki, NormanSachs, KayWiebrands, Saskia I JEllenbroek, AriannaFumagalli, AnnaLyubimova, HarryBegthel, Maaikevan den Born, Johan Hvan Es, Wouter RKarthaus, Vivian S WLi, CarmenLópez-Iglesias, Peter JPeters, Jaccovan Rheenen, Alexandervan Oudenaarden, HansClevers

Sequential intravital imaging reveals in vivo dynamics of pancreatic tissue transplanted under the kidney capsule in mice
2016

Léonvan Gurp, Cindy J MLoomans, Pim Pvan Krieken, GitanjaliDharmadhikari, ErikJansen, Femke C A SRingnalda, EvelyneBeerling, Jaccovan Rheenen, Eelco J Pde Koning

LIM Kinase Inhibitor Pyr1 Reduces the Growth and Metastatic Load of Breast Cancers
2016

ChloéPrunier, VéroniqueJosserand, JulienVollaire, EvelyneBeerling, ChristosPetropoulos, OlivierDestaing, ChristopherMontemagno, AmandineHurbin, RenaudPrudent, Leannede Koning, ReubenKapur, Pascale ACohen, CorinneAlbiges-Rizo, Jean-LucColl, Jaccovan Rheenen, MarcBillaud, LaurenceLafanechère

Implications of Extracellular Vesicle Transfer on Cellular Heterogeneity in Cancer
2016

AnoekZomer, Jaccovan Rheenen

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility
2016

LoredanaVecchione, ValentinaGambino, JonneRaaijmakers, AndreasSchlicker, AriannaFumagalli, MariangelaRusso, AlbertoVillanueva, EvelyneBeerling, AliceBartolini, David GMollevi, NizarEl-Murr, MarielleChiron, LoreleyCalvet, CélineNicolazzi, CécileCombeau, ChristopheHenry, Iris MSimon, SunTian, SjorsIn 't Veld, GiovanniD'ario, SaraMainardi, Roderick LBeijersbergen, CorLieftink, SabineLinn, CorneliaRumpf-Kienzl, MauroDelorenzi, LodewykWessels, RamonSalazar, FedericaDi Nicolantonio, AlbertoBardelli, Jaccovan Rheenen, René HMedema, SabineTejpar, RenéBernards

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity
2016

EvelyneBeerling, DaniëlleSeinstra, Elzode Wit, LennartKester, Daphnevan der Velden, CarrieMaynard, RonnySchäfer, Paulvan Diest, EmileVoest, Alexandervan Oudenaarden, NienkeVrisekoop, Jaccovan Rheenen

Studying extracellular vesicle transfer by a Cre-loxP method
2016

AnoekZomer, Sander ChristiaanSteenbeek, CarrieMaynard, Jaccovan Rheenen

PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena
2015

Shannon KHughes, Madeleine JOudin, JennyTadros, JasonNeil, AmandaDel Rosario, Brian AJoughin, LailaRitsma, JeffWyckoff, ElizaVasile, RobertEddy, UlrikePhilippar, AlishaLussiez, John SCondeelis, Jaccovan Rheenen, ForestWhite, Douglas ALauffenburger, Frank BGertler

In Vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior
2015

AnoekZomer, CarrieMaynard, Frederik JohannesVerweij, AlwinKamermans, RonnySchäfer, EvelyneBeerling, Raymond MichelSchiffelers, Elzode Wit, JordiBerenguer, Saskia Inge JohannaEllenbroek, ThomasWurdinger, Dirk MichielPegtel, Jaccovan Rheenen

The mechanisms and physiological relevance of glycocalyx degradation in hepatic ischemia/reperfusion injury
2014

Rowan Fvan Golen, Megan JReiniers, NienkeVrisekoop, Coert JZuurbier, Pim BOlthof, Jaccovan Rheenen, Thomas Mvan Gulik, Barry JParsons, MichalHeger

Imaging hallmarks of cancer in living mice
2014

Saskia I JEllenbroek, Jaccovan Rheenen

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging
2014

LailaRitsma, Saskia I JEllenbroek, AnoekZomer, Hugo JSnippert, Frederic Jde Sauvage, Benjamin DSimons, HansClevers, Jaccovan Rheenen

Surgical implantation of an abdominal imaging window for intravital microscopy
2013

L.Ritsma, E.J.Steller, S.I.Ellenbroek, O.Kranenburg, I.H.Rinkes, J.van Rheenen

A versatile toolkit to produce sensitive FRET biosensors to visualize signaling in time and space
2013

R.D.Fritz, M.Letzelter, A.Reimann, K.Martin, L.Fusco, L.Ritsma, B.Ponsioen, E.Fluri, S.Schulte-Merker, J.van Rheenen, O.Pertz

Intravital imaging of cancer stem cell plasticity in mammary tumors
2013

A.Zomer, S.I.Ellenbroek, L.Ritsma, E.Beerling, N.Vrisekoop, J.van Rheenen

In vivo imaging and histochemistry are combined in the cryosection labelling and intravital microscopy technique
2013

L.Ritsma, N.Vrisekoop, J.van Rheenen

Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy
2013

A.Janssen, E.Beerling, R.Medema, J.van Rheenen

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen
2012

S.Ariotti, J.B.Beltman, G.Chodaczek, M.E.Hoekstra, A.E.van Beek, R.Gomez-Eerland, L.Ritsma, J.van Rheenen, A.F.Maree, T.Zal, R.J.de Boer, J.B.Haanen, T.N.Schumacher

Intravital microscopy through an abdominal imaging window reveals a pre-micrometastasis stage during liver metastasis
2012

L.Ritsma, E.J.Steller, E.Beerling, C.J.Loomans, A.Zomer, C.Gerlach, N.Vrisekoop, D.Seinstra, L.van Gurp, R.Schafer, D.A.Raats, A.de Graaff, T.N.Schumacher, E.de Koning, I.H.Rinkes, O.Kranenburg, J.van Rheenen