Catherine Rabouille received her PhD in biochemistry in 1988, followed by postdoctoral experiences at the Joslin Diabetes Centre (Boston, MA), the UMC Utrecht (NL) and the Imperial Cancer Research Fund (London, UK) in the lab of Graham Warren where she started working on the Golgi and his fate during mitosis using electron microscopy. In 1998, she was the recipient of a Career Development Award from the Medical Research Council (UK) to set up her lab at the Wellcome trust Centre for Cell biology (Edinburgh, UK). There, she started her work on the functional organization of the early secretory pathway during Drosophila development. In 2002, she was offered an Associate professorship at the UMC Utrecht at the Department of Cell Biology where she continued her line of research focusing on Drosophila oogenesis as well as S2 cells. In 2010, she became a senior group leader at the Hubrecht Institute.
Team membersRabouille groep
Amalia Marin Escobar
Wessel van Leeuwen
Monique van der Voet
Marinke van Oorschot
Regulation of secretion during development Delivery of newly synthesized proteins to the plasma membrane and the extracellular medium takes place in the membrane organelle of the secretory pathway. The molecular machinery behind the functional organization of this pathway is tightly controlled and is regulated by signaling. In this context, we study the role of ERK7 in Drosophila S2 cells. In addition to this classical secretion, a number of transmembrane proteins are unconventionally deposited to the plasma membrane, a pathway whose biogenesis is triggered by mechanical stress at specific stages of development. We study this unconventional secretion pathway in Drosophila as...
Zacharogianni, M., A. Aguilera, J. Smout, T. Veenendaal, and C. Rabouille (2014). A reversible non-membrane bound stress assembly that confers cell viability by preserving COPII components during amino-acid starvation. In revision at Elife.
Bellouze M, M.K. Schäfer, D. Buttigieg, G. Baillat, C. Rabouille and G. Haase (2014). Golgi fragmentation in pmn mice is due to a defective ARF1/TBCE cross talk that coordinates COPI vesicle formation and tubulin polymerization. Hum. Mol. Genet. Jun 20. pii: ddu320.
Giuliani, G., F. Giuliani, T. Volk and C. Rabouille (2013).The Drosophila RNA-binding protein HOW controls the stability of dgrasp mRNA in the follicular epithelium.
Nucleic Acids Res. 42(3):1970-86.
Weil, T.T., R.M. Parton, B. Herpers, J. Soetaert, T. Veenendaal, D. Xanthakis, I.M. Dobbie, J. Halstead, R. Hayashi, C. Rabouille* and I. Davis1* (2012). Drosophila patterning is established by differential association of mRNAs with P bodies. Nat. Cell Biol. 14:1305-13.
Zacharogianni, M., V. Kondylis, Y. Tang, D. Xanthakis, H. Farhan, F. Fuchs, M. Boutros and C. Rabouille (2011). ERK7 is a negative regulator of protein secretion in response to amino acid starvation by modulating Sec16 membrane association. EMBO J. 30:3684-700.
Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila2017
Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation2017
AngelicaAguilera-Gomez, MargaritaZacharogianni, Marinke Mvan Oorschot, HeideGenau, RianneGrond, TinekeVeenendaal, Kristina SSinsimer, Elizabeth RGavis, ChristianBehrends, CatherineRabouille
AngelicaAguilera-Gomez, Marinke Mvan Oorschot, TinekeVeenendaal, CatherineRabouille
Localized Translation of gurken/TGF-α mRNA during Axis Specification Is Controlled by Access to Orb/CPEB on Processing Bodies2016
AlexanderDavidson, Richard MParton, CatherineRabouille, Timothy TWeil, IlanDavis
SarahBellouze, GilbertBaillat, DorothéeButtigieg, Pierrede la Grange, CatherineRabouille, GeorgHaase
CatherineRabouille, Adam DLinstedt
IrenaJevtov, MargaritaZacharogianni, Marinke Mvan Oorschot, Guusvan Zadelhoff, AngelicaAguilera-Gomez, IgorVuillez, InekeBraakman, ErnstHafen, HugoStocker, CatherineRabouille
Innexin7a forms junctions that stabilize the basal membrane during cellularization of the blastoderm in Tribolium castaneum2015
Maurijnvan der Zee, Matthew ABenton, TaniaVazquez-Faci, Gerda E MLamers, Chris G CJacobs, CatherineRabouille
Loss of a Clueless-dGRASP complex results in ER stress and blocks Integrin exit from the perinuclear endoplasmic reticulum in Drosophila larval muscle2015
Zong-HengWang, CatherineRabouille, Erika RGeisbrecht
Golgi Fragmentation in ALS Motor Neurons. New Mechanisms Targeting Microtubules, Tethers, and Transport Vesicles2015
Golgi fragmentation in pmn mice is due to a defective ARF1/TBCE cross-talk that coordinates COPI vesicle formation and tubulin polymerization2014
SarahBellouze, Michael KSchäfer, DorothéeButtigieg, GilbertBaillat, CatherineRabouille, GeorgHaase