Catherine Rabouille received her PhD in biochemistry in 1988, followed by postdoctoral experiences at the Joslin Diabetes Centre (Boston, MA), the UMC Utrecht (NL) and the Imperial Cancer Research Fund (London, UK) in the lab of Graham Warren where she started working on the Golgi and his fate during mitosis using electron microscopy. In 1998, she was the recipient of a Career Development Award from the Medical Research Council (UK) to set up her lab at the Wellcome trust Centre for Cell biology (Edinburgh, UK). There, she started her work on the functional organization of the early secretory pathway during Drosophila development. In 2002, she was offered an Associate professorship at the UMC Utrecht at the Department of Cell Biology where she continued her line of research focusing on Drosophila oogenesis as well as S2 cells. In 2010, she became a senior group leader at the Hubrecht Institute.
Team membersRabouille groep
Amalia Marin Escobar
Wessel van Leeuwen
Angelica Aquilera Gomez
Monique van der Voet
Marinke van Oorschot
Regulation of secretion during development Delivery of newly synthesized proteins to the plasma membrane and the extracellular medium takes place in the membrane organelle of the secretory pathway. The molecular machinery behind the functional organization of this pathway is tightly controlled and is regulated by signaling. In this context, we study the role of ERK7 in Drosophila S2 cells. In addition to this classical secretion, a number of transmembrane proteins are unconventionally deposited to the plasma membrane, a pathway whose biogenesis is triggered by mechanical stress at specific stages of development. We study this unconventional secretion pathway in Drosophila as...
Zacharogianni, M., A. Aguilera, J. Smout, T. Veenendaal, and C. Rabouille (2014). A reversible non-membrane bound stress assembly that confers cell viability by preserving COPII components during amino-acid starvation. In revision at Elife.
Bellouze M, M.K. Schäfer, D. Buttigieg, G. Baillat, C. Rabouille and G. Haase (2014). Golgi fragmentation in pmn mice is due to a defective ARF1/TBCE cross talk that coordinates COPI vesicle formation and tubulin polymerization. Hum. Mol. Genet. Jun 20. pii: ddu320.
Giuliani, G., F. Giuliani, T. Volk and C. Rabouille (2013).The Drosophila RNA-binding protein HOW controls the stability of dgrasp mRNA in the follicular epithelium.
Nucleic Acids Res. 42(3):1970-86.
Weil, T.T., R.M. Parton, B. Herpers, J. Soetaert, T. Veenendaal, D. Xanthakis, I.M. Dobbie, J. Halstead, R. Hayashi, C. Rabouille* and I. Davis1* (2012). Drosophila patterning is established by differential association of mRNAs with P bodies. Nat. Cell Biol. 14:1305-13.
Zacharogianni, M., V. Kondylis, Y. Tang, D. Xanthakis, H. Farhan, F. Fuchs, M. Boutros and C. Rabouille (2011). ERK7 is a negative regulator of protein secretion in response to amino acid starvation by modulating Sec16 membrane association. EMBO J. 30:3684-700.
AngelicaAguilera-Gomez, Marinke Mvan Oorschot, TinekeVeenendaal, CatherineRabouille
Localized Translation of gurken/TGF-α mRNA during Axis Specification Is Controlled by Access to Orb/CPEB on Processing Bodies2016 in21100201068
AlexanderDavidson, Richard MParton, CatherineRabouille, Timothy TWeil, IlanDavis
SarahBellouze, GilbertBaillat, DorothéeButtigieg, Pierrede la Grange, CatherineRabouille, GeorgHaase
CatherineRabouille, Adam DLinstedt
IrenaJevtov, MargaritaZacharogianni, Marinke Mvan Oorschot, Guusvan Zadelhoff, AngelicaAguilera-Gomez, IgorVuillez, InekeBraakman, ErnstHafen, HugoStocker, CatherineRabouille
Innexin7a forms junctions that stabilize the basal membrane during cellularization of the blastoderm in Tribolium castaneum2015 in14090
Maurijnvan der Zee, Matthew ABenton, TaniaVazquez-Faci, Gerda E MLamers, Chris G CJacobs, CatherineRabouille
Loss of a Clueless-dGRASP complex results in ER stress and blocks Integrin exit from the perinuclear endoplasmic reticulum in Drosophila larval muscle2015 in21100444312
Zong-HengWang, CatherineRabouille, Erika RGeisbrecht
Golgi Fragmentation in ALS Motor Neurons. New Mechanisms Targeting Microtubules, Tethers, and Transport Vesicles2015 in21100199812
Golgi fragmentation in pmn mice is due to a defective ARF1/TBCE cross-talk that coordinates COPI vesicle formation and tubulin polymerization2014 in22266
SarahBellouze, Michael KSchäfer, DorothéeButtigieg, GilbertBaillat, CatherineRabouille, GeorgHaase
The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima2014 in12977
Ariel DChipman, David E KFerrier, CarloBrena, JiaxinQu, Daniel S THughes, ReinhardSchröder, MontserratTorres-Oliva, NadiaZnassi, HuaiyangJiang, Francisca CAlmeida, Claudio RAlonso, ZivkosApostolou, PeshtewaniAqrawi, WallaceArthur, Jennifer C JBarna, Kerstin PBlankenburg, DanielaBrites, SalvadorCapella-Gutiérrez, MarcusCoyle, Peter KDearden, LouisDu Pasquier, Elizabeth JDuncan, DieterEbert, CorneliusEibner, GalinaErikson, Peter DEvans, Cassandra GExtavour, LiezlFrancisco, ToniGabaldón, William JGillis, Elizabeth AGoodwin-Horn, Jack EGreen, SamGriffiths-Jones, Cornelis J PGrimmelikhuijzen, SaiGubbala, RodericGuigó, YiHan, FrankHauser, PaulHavlak, LukeHayden, SophieHelbing, MichaelHolder, Jerome H LHui, Julia PHunn, Vera SHunnekuhl, LaRondaJackson, MehwishJavaid, Shalini NJhangiani, Francis MJiggins, Tamsin EJones, Tobias SKaiser, DivyaKalra, Nathan JKenny, ViktoriyaKorchina, Christie LKovar, F BernhardKraus, FrançoisLapraz, Sandra LLee, JieLv, ChristigaleMandapat, GerardManning, MarcoMariotti, RobertMata, TittuMathew, TobiasNeumann, IreneNewsham, Dinh NNgo, MariaNinova, GeoffreyOkwuonu, FionaOngeri, William JPalmer, ShobhaPatil, PedroPatraquim, ChristopherPham, Ling-LingPu, Nicholas HPutman, CatherineRabouille, Olivia MendivilRamos, Adelaide CRhodes, Helen ERobertson, Hugh MRobertson, MatthewRonshaugen, JulioRozas, NehadSaada, AlejandroSánchez-Gracia, Steven EScherer, Andrew MSchurko, Kenneth WSiggens, DeNardSimmons, AnnaStief, EckartStolle, Maximilian JTelford, KristinTessmar-Raible, RebeccaThornton, Maurijnvan der Zee, Arndtvon Haeseler, James MWilliams, Judith HWillis, YuanqingWu, XiaoyanZou, DanielLawson, Donna MMuzny, Kim CWorley, Richard AGibbs, MichaelAkam, StephenRichards
Adam GGrieve, CatherineRabouille
The Drosophila RNA-binding protein HOW controls the stability of dgrasp mRNA in the follicular epithelium2014 in14204
GiulianoGiuliani, FabrizioGiuliani, TalilaVolk, CatherineRabouille
TinekeVeenendaal, TimJarvela, Adam GGrieve, Johan Hvan Es, Adam DLinstedt, CatherineRabouille
A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation2014 in21100242814
MargaritaZacharogianni, Angelica AguileraGomez, TinekeVeenendaal, JanSmout, CatherineRabouille