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Selected publications

Etemad B, Kuijt TEF, Kops GJPL. Kinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint. Nat Commun (2015) in press
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Hiruma, Y, Sacristan C, Pachis ST, Adamopoulos A, Kuijt T, Ubbink M, Von Castelmur E, Perrakis A, Kops GJPL. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling. Science 348 (2015), 1264-1267.

Drost J, Van Jaarsveld RH, Ponsioen B, Zimberlin C, Van Boxtel R, Buijs A, Sachs N, Overmeer RM, Offerhaus GJ, Schwank G, Begthel H, Korving J, Logtenberg M, Cuppen E, Snippert HJ, Medema JP, Kops GJPL, Clevers H. Sequential cancer mutations in cultured human intestinal stem cells. Nature 521 (2015), 43-7.

Vleugel M, Omerzu M, Groenewold V, Hadders MA, Lens SM, Kops GJPL. Sequential multisite phospho-regulation of KNL1-BUB3 interfaces at mitotic kinetochores. Mol Cell 57 (2015), 824-35.

Nijenhuis W, Vallardi G, Van den Dikkenberg A, Kops GJPL*, Saurin AT*. Negative feedback at kinetochores underlies a responsive spindle checkpoint signal. Nat Cell Biol. 16 (2014), 1257-64.

*equal contribution and correspondence.

Suijkerbuijk SJE, Vleugel M, Teixiera A, Kops GJPL. Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments. Dev Cell 23 (2012), 745-755.

Suijkerbuijk SJE, Van Dam TJP, Karagöz GE, Von Castelmur E, Hubner NC, Duarte AMS, Vleugel M, Perrakis A, Rüdiger SGD, Snel B, Kops GJPL. The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase. Dev Cell 22 (2012), 1321-9.

Janssen A, Van der Burg, M, Szuhai, K, Kops GJPL*, Medema RH*. Chromosome segregation errors as a cause of DNA damage and structural chromosome aberration. Science 333 (2011), 1895-8.

*corresponding authors

Janssen A, Kops GJPL*, Medema RH*. Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proc Natl Acad Sci U S A 106 (2009), 19108-13.

* equal contribution and correspondence

Jelluma N, Brenkman AB, Van den Broek NJF, Cruijsen CWA, Van Osch MHJ, Lens SMA, Medema RH and Kops GJPL. Mps1 phosphorylates borealin to control aurora B activity and chromosome alignment. Cell 132 (2008) 233-246.