Team membersDeschamps groep

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Key publications

Amin S, Neijts R, Simmini S, van Rooijen C, Tan SC, Kester L, van Oudenaarden A, Creyghton MP and Deschamps J. (2016) Cdx and T Brachyury co-activate growth signaling in the embryonic axial progenitor niche. Cell Reports, Dec 20; 17, 3165–3177
(download Amin et al., 2016)

Neijts R, Amin S, van Rooijen C, Tan D, Creyghton MP, de Laat W, and Deschamps J. (2016) Polarized regulatory landscape and Wnt responsiveness underlie Hox activation in embryos. Genes & Development , Sep 1; 30 (17)
(download Neijts et al. 2016)

Deschamps J. (2016). Birth and upgrowth of the Hox topological domains during evolution. Nature Genetics (News and Views), Feb 24; 48(3):227-228.

Simmini S., Bialecka M., Huch M., Kester L., van de Wetering M., Sato T., Beck F., van Oudenaarden A., Clevers H. and Deschamps J. (2014). Transformation of intestinal stem cells into gastric stem cells upon loss of transcription factor Cdx2. Nature Communications, Dec 11; 5: 5728.

Neijts R., Simmini S., Giuliani F., van Rooijen C and Deschamps J. (2014) Region-Specific Regulation of Posterior Axial Elongation During Vertebrate Embryogenesis Dev. Dynamics 243, 88-98.

van Rooijen C., Simmini S., Bialecka M., Neijts R., van de Ven C., Beck F. and Deschamps J. (2012). Evolutionary conserved requirement of Cdx for post-occipital tissue emergence.Development 139, 2576-2583.

Van de Ven C., Bialecka M., Neijts R., Young, T., Rowland J., Stringer E.,van Rooijen C, Meijlink F., Novoa A., Freund JN., Mallo M., Beck F. and Deschamps J. (2011). Concerted involvement of Hox/Cdx genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development 138, 3451-3462.

Bialecka M., Wilson V and Deschamps (2010). Cdx mutations causing posterior axial truncations do not impair the long term tissue progenitors in the embryonic posterior growth zone.Developmental Biology 347, 228-234.

Young, T., Rowland, J., van de Ven, C., Bialecka, M., Novoa, A., Carapuco, M., van Nes, J., de Graaff, W., Duluc, I., Freund, JN., Beck, F., Mallo, M. and Deschamps, J. (2009). Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Developmental Cell 17, 516-526.

Young T., and Deschamps J. (2009) Hox and Cdx genes in axial extension and patterning in the mouse embryo. Cur. Topics in Genetics and Development 88, 33-53. .

Deschamps J. and Van Nes J. (2005). Developmental regulation of the Hox genes during axial morphogenesis in the mouse.Development 132, 2931-2942.

Holstege J., de Graaff W., Hossaini, M., Cardone-Cardo., S., Jaarsma D., van den Akker, E. and Deschamps J. (2008) Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice. Proc. Natn. Acad. Sci. USA 105, 6338-6343.

Deschamps J.,(2007) Ancestral and recently recruited global control of the Hox genes in development. Current Opin. Genet Dev . 17, 422-427.

van Nes J, de Graaff W., Lebrin F., Gerhard, M., Beck F. and Deschamps J. (2006) The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice. Development 133. 419-28.

Deschamps J. and van Nes J. (2005) Developmental regulation of the Hox genes during axial morphogenesis in the mouse. Development 132, 2931-2942.

Forlani, S., Lawson, K.A. and Deschamps, J. (2003) Acquisition of Hox codes during gastrulation and axial elongation in the mouse embryo. Development 130, 3807-3819.

Oosterveen, T, Nierderreither K., Dollé P., Chambon, P., Meijlink, F. and Deschamps J. (2003) Retinoids regulate the anterior boundaries of 5’Hoxb genes in posterior hindbrain. EMBO J., 22, 262-269