Team membersde Laat groep

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Key publications

de Vree PJP, de Wit E, Yilmaz M, van de Heijning M, Klous P, Verstegen MJAM, Wan Y, Teunissen H, Krijger PHL, Geeven G, Eijk PP, Sie D, Ylstra B, Hulsman LOM, van Dooren MF, van Zutven LJCM, van den Ouweland A, Verbeek S, van Dijk KW, Cornelissen M, Das AT, Berkhout B, Sikkema-Raddatz B, van den Berg E, van der Vlies P, Weening D, den Dunnen JT, Matusiak M, Lamkanfi M,  Ligtenberg MJL, ter Brugge P, Jonkers J, Foekens JA, Martens JW, van der Luijt R, Ploos van Amstel HK, van  Min M, Splinter E, de Laat W (2014). Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping. Nature Biotechnology 32(10):1019-25.

de Laat W, Duboule D (2013). Topology of mammalian developmental enhancers and their regulatory landscapes. Nature 502(7472):499-506.

de Wit E, Bouwman BA, Zhu Y, Klous P, Splinter E, Verstegen MJ, Krijger PH, Festuccia N, Nora EP, Welling M, Heard E, Geijsen N, Poot RA, Chambers I, de Laat W. (2013) The pluripotent genome in three dimensions is shaped around pluripotency factors. Nature 501(7466):227-31.

van de Werken H, Landan G, Holwerda S, Hoichman M, Klous P, Chachik R, Splinter E, Valdes Quezada C, Öz Y, Bouwman B, Verstegen M, de Wit E, Tanay A, de Laat W. (2012). Robust 4C-seq data analysis to screen for regulatory DNA interactions. Nature Methods 9:969-72.

Noordermeer D#, de Wit E#, Klous P#, van de Werken H, Simonis M, Lopez-Jones M, Eussen B, de Klein A, Singer RH, de Laat W. (2011). Variegated gene expression caused by cell-specific long-range DNA interactions. Nat Cell Biol 13:944-51.
#equal contributions

de Laat W, Duboule D (2013). Topology of mammalian developmental enhancers and their regulatory landscapes. Nature 502(7472):499-506.

de Wit E, Bouwman BA, Zhu Y, Klous P, Splinter E, Verstegen MJ, Krijger PH, Festuccia N, Nora EP, Welling M, Heard E, Geijsen N, Poot RA, Chambers I, de Laat W. (2013) The pluripotent genome in three dimensions is shaped around pluripotency factors. Nature 501(7466):227-31.

van de Werken H, Landan G, Holwerda S, Hoichman M, Klous P, Chachik R, Splinter E, Valdes Quezada C, Öz Y, Bouwman B, Verstegen M, de Wit E, Tanay A, de Laat W. (2012). Robust 4C-seq data analysis to screen for regulatory DNA interactions. Nature Methods 9:969-72.

Noordermeer D#, de Wit E#, Klous P#, van de Werken H, Simonis M, Lopez-Jones M, Eussen B, de Klein A, Singer RH, de Laat W. (2011). Variegated gene expression caused by cell-specific long-range DNA interactions. Nat Cell Biol 13:944-51.
#equal contributions

All publications

Regulation of disease-associated gene expression in the 3D genome
2016

Peter Hugo LodewijkKrijger, Wouterde Laat

Polarized regulatory landscape and Wnt responsiveness underlie Hox activation in embryos
2016

RoelNeijts, ShiluAmin, Carinavan Rooijen, SanderTan, Menno PCreyghton, Wouterde Laat, JacquelineDeschamps

The second decade of 3C technologies
2016

AnnetteDenker, Wouterde Laat

Cell-of-Origin-Specific 3D Genome Structure Acquired during Somatic Cell Reprogramming
2016

Peter Hugo LodewijkKrijger, BrunoDi Stefano, Elzode Wit, FrancescoLimone, Chrisvan Oevelen, Wouterde Laat, ThomasGraf

Epigenomic annotation of gene regulatory alterations during evolution of the primate brain
2016

Marit WVermunt, Sander CTan, BasCastelijns, GeertGeeven, PeterReinink, Ewartde Bruijn, IvanelaKondova, StephanPersengiev, RonaldBontrop, EdwinCuppen, Wouterde Laat, Menno PCreyghton, Netherlands Brain Bank

Cause and Consequence of Tethering a SubTAD to Different Nuclear Compartments
2016

Patrick JWijchers, Peter H LKrijger, GeertGeeven, YunZhu, AnnetteDenker, Marjon J A MVerstegen, ChristianValdes-Quezada, CarloVermeulen, MarkJanssen, HansTeunissen, Lisette C MAnink-Groenen, Pernette JVerschure, Wouterde Laat

Enhancers reside in a unique epigenetic environment during early zebrafish development
2016

Lucas J TKaaij, MichalMokry, MengZhou, MichaelMusheev, GeertGeeven, Adrien S JMelquiond, António Mde Jesus Domingues, Wouterde Laat, ChristofNiehrs, Andrew DSmith, René FKetting

Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures
2016

XinchenWang, Nathan RTucker, GizemRizki, RobertMills, Peter HlKrijger, Elzode Wit, VidyaSubramanian, EricBartell, Xinh-XinhNguyen, JiangchuanYe, JordanLeyton-Mange, Elena VDolmatova, Pimvan der Harst, Wouterde Laat, Patrick TEllinor, ChristopherNewton-Cheh, David JMilan, ManolisKellis, Laurie ABoyer

Erratum to
2016

HendrikMarks, Hindrik H DKerstens, Tahsin StefanBarakat, ErikSplinter, René A MDirks, Guidovan Mierlo, OnkarJoshi, Shuang-YinWang, TomasBabak, Cornelis AAlbers, TüzerKalkan, AustinSmith, AliceJouneau, Wouterde Laat, JoostGribnau, Hendrik GStunnenberg

Transcription of Mammalian cis-Regulatory Elements Is Restrained by Actively Enforced Early Termination
2015

Liv M IAustenaa, IrosBarozzi, MartaSimonatto, SilviaMasella, GiuliaDella Chiara, SerenaGhisletti, AlessiaCurina, Elzode Wit, Britta A MBouwman, Stefanode Pretis, VivianaPiccolo, AlbertoTermanini, ElenaProsperini, MattiaPelizzola, Wouterde Laat, GioacchinoNatoli

CTCF Binding Polarity Determines Chromatin Looping
2015

Elzode Wit, Erica S MVos, Sjoerd J BHolwerda, ChristianValdes-Quezada, Marjon J A MVerstegen, HansTeunissen, ErikSplinter, Patrick JWijchers, Peter H LKrijger, Wouterde Laat

YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers
2015

Giorgio GGalli, MatteoCarrara, Wei-ChienYuan, ChristianValdes-Quezada, BasantaGurung, BrianPepe-Mooney, TinghuZhang, GeertGeeven, Nathanael SGray, Wouterde Laat, Raffaele ACalogero, Fernando DCamargo

High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila
2015

FidelRamírez, ThomasLingg, SarahToscano, Kin ChungLam, PlamenGeorgiev, Ho-RyunChung, Bryan RLajoie, Elzode Wit, YeZhan, Wouterde Laat, JobDekker, ThomasManke, AsifaAkhtar

A Long-Distance Chromatin Affair
2015

AnnetteDenker, Wouterde Laat

Architectural hallmarks of the pluripotent genome
2015

Britta A MBouwman, Wouterde Laat

Characterization and dynamics of pericentromere-associated domains in mice
2015

Patrick JWijchers, GeertGeeven, MichaelEyres, Atze JBergsma, MarkJanssen, MarjonVerstegen, YunZhu, YoriSchell, CarloVermeulen, Elzode Wit, Wouterde Laat

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA
2015

NicolasLéveillé, Carlos AMelo, KoosRooijers, AngelDíaz-Lagares, Sonia AMelo, GozdeKorkmaz, RuiLopes, FarhadAkbari Moqadam, Ana RMaia, Patrick JWijchers, GeertGeeven, Monique Lden Boer, RaghuKalluri, Wouterde Laat, ManelEsteller, ReuvenAgami

Getting the genome in shape
2015

Britta AmBouwman, Wouterde Laat

Dynamics of gene silencing during X inactivation using allele-specific RNA-seq
2015

HendrikMarks, Hindrik H DKerstens, Tahsin StefanBarakat, ErikSplinter, René A MDirks, Guidovan Mierlo, OnkarJoshi, Shuang-YinWang, TomasBabak, Cornelis AAlbers, TüzerKalkan, AustinSmith, AliceJouneau, Wouterde Laat, JoostGribnau, Hendrik GStunnenberg

Local compartment changes and regulatory landscape alterations in histone H1-depleted cells
2015

GeertGeeven, YunZhu, Byung JuKim, Boris ABartholdy, Seung-MinYang, Todd SMacfarlan, Wesley DGifford, Samuel LPfaff, Marjon J A MVerstegen, HugoPinto, Marit WVermunt, Menno PCreyghton, Patrick JWijchers, John AStamatoyannopoulos, Arthur ISkoultchi, Wouterde Laat