Eelco de Koning

Eelco de Koning (1963) received his medical doctorate at the University of Utrecht, the Netherlands, in 1991. Subsequently, he moved to England and started research into islet biology and pathology at the Diabetes Research Laboratories in Oxford under supervison of Anne Clark and Robert Turner. He obtained a MRC Training Fellowship to finish these studies which resulted in a PhD thesis in 1994. In the same year he started his training in Internal Medicine followed by a fellowship in Endocrinology at the University Medical Center Utrecht (UMCU). He was board certified in endocrinology in 2001. He joined the research group of Ton Rabelink at the UMCU focusing on complications in diabetes mellitus. In 2004 this group moved to the Leiden University Medical Center (LUMC). In addition, in 2004 a Career Development Grant awarded by the Dutch Diabetes Research Foundation and a fellowship from the Joslin Diabetes Center (Harvard Medical School) in Boston laid the foundations of his current clinical and research activities. From 2004-2005 he joined the groups of Susan Bonner-Weir and Gordon Weir at the Department of Islet Transplantation and Cell Biology (Joslin Diabetes Center). In their groups he participated in the clinical human islet isolation and transplantation program and in islet progenitor cell research. In 2006 he returned to the LUMC to establish a laboratory for human islet isolation under GMP conditions and to direct the clinical islet transplantation program in the Netherlands. This program is operational since 2007. In 2010 he also joined the Hubrecht Institute focusing on islet progenitor cell research. Using a bench-to-bedside approach he has initiated and heads multicenter research programs on improvement of islet transplantation and use of islet progenitor cells for beta-cell therapy. He was appointed professor of diabetology at the University of Leiden in 2011.

e.koning(at)hubrecht.eu

Team membersde Koning groep

Juliëtte Wezenbeek

Student

Mark Tielemans

Student

Juri Juksar

PhD Student

Cindy Loomans

Guest

Cindy Loomans

Bernard van den Berg

Guest

Bernard van den Berg

Ton Rabelink

Guest

Ton Rabelink

Antonius de Waard

Student

Antonius de Waard

Nerys Williams

PhD Student

Nerys Williams

Gitanjali Dharmadhikari

Postdoc

Erik Jansen

Technician

Erik Jansen

Léon van Gurp

Technician

Eelco de Koning

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Onderzoek

De Koning: Diabetes and islet neogenesis

Replacement of the insulin-producing beta cells in the islets of Langerhans in the pancreas is the only option to restore normoglycemia without an increased risk of hypoglycemia in patients with type 1 diabetes. Currently we can perform this therapy in a small group of patients by pancreas or islet transplantation. But a shortage of donor organs limits the wider application of beta-cell replacement therapy. Therefore, alternative cell sources are necessary to generate sufficient beta-cells for future therapy. In collaboration with the Leiden University Medical Center we explore the use of human pancreatic progenitor cells to reach this goal....

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All publications

MiR-184 expression is regulated by AMPK in pancreatic islets
2017

AidaMartinez-Sanchez, Marie-SophieNguyen-Tu, InesCebola, ArashYavari, PieroMarchetti, LorenzoPiemonti, Eelcode Koning, A M JamesShapiro, PaulJohnson, KeiSakamoto, David MSmith, IsabelleLeclerc, HoumanAshrafian, JorgeFerrer, Guy ARutter

Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type-specific methylation in enhancers
2017

DanielNeiman, JoshuaMoss, MeravHecht, JudithMagenheim, SheinaPiyanzin, A M JamesShapiro, Eelco J Pde Koning, AharonRazin, HowardCedar, RuthShemer, YuvalDor

Pancreatic α-cell mass in obesity
2017

Johanne HEllenbroek, Hendrica A MTöns, Maaike A JHanegraaf, Ton JRabelink, Marten AEngelse, FrançoiseCarlotti, Eelco J Pde Koning

Layered PEGDA hydrogel for islet of Langerhans encapsulation and improvement of vascularization
2017

GiuliaMarchioli, LisaZellner, CatarinaOliveira, Marten AEngelse, Eelco deKoning, JoaoMano, MarcelKarperien, Aart vanApeldoorn, LorenzoMoroni

DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells
2017

Matthias SRoost, Roderick CSlieker, MonikaBialecka, Liesbethvan Iperen, Maria MGomes Fernandes, NannanHe, H Eka DSuchiman, KarolySzuhai, FrançoiseCarlotti, Eelco J Pde Koning, Christine LMummery, Bastiaan THeijmans, Susana MChuva de Sousa Lopes

Pancreas transplantation with grafts from donors deceased after circulatory death (DCD)
2017

Wouter HKopp, Hwai-DingLam, Alexander F MSchaapherder, Volkert A LHuurman, Paulvan der Boog, Eelcode Koning, Johan Wde Fijter, AndrzejBaranski, Andries EBraat

Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet-transplantation enhances immediate post-transplant islet graft function but not long-term normoglycemia
2017

Alexandra MSmink, ShiriLi, Daniël HSwart, Don THertsig, Bart Jde Haan, Jan A A MKamps, LeendertSchwab, Aartvan Apeldoorn, Eelcode Koning, Marijke MFaas, Jonathan R TLakey, Paulde Vos

Pancreatic islet macroencapsulation using microwell porous membranes
2017

KatarzynaSkrzypek, MilouGroot Nibbelink, Jérévan Lente, MijkeBuitinga, Marten AEngelse, Eelco J Pde Koning, MarcelKarperien, Aartvan Apeldoorn, DimitriosStamatialis

Micro-fabricated scaffolds lead to efficient remission of diabetes in mice
2017

MijkeBuitinga, FrankAssen, MaaikeHanegraaf, PaulWieringa, JannekeHilderink, LorenzoMoroni, RomanTruckenmüller, Clemensvan Blitterswijk, Gert-WillemRömer, FrançoiseCarlotti, Eelcode Koning, MarcelKarperien, Aartvan Apeldoorn

Increased vimentin in human α- and β-cells in type 2 diabetes
2017

Maaike MRoefs, FrançoiseCarlotti, KatherineJones, HannahWills, AlexanderHamilton, MichaelVerschoor, Joanna M WilliamsDurkin, LauraGarcia-Perez, Melissa FBrereton, LauraMcCulloch, Marten AEngelse, Paul R VJohnson, Barbara CHansen, KevinDocherty, Eelco J Pde Koning, AnneClark

Association of fasting triglyceride concentration and postprandial triglyceride response with the carotid intima-media thickness in the middle aged
2017

TimChristen, Renéede Mutsert, Karin BGast, Patrick C NRensen, Eelcode Koning, Frits RRosendaal, StellaTrompet, J WouterJukema

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes
2017

GitanjaliDharmadhikari, KatharinaStolz, MichaelHauke, Noel GMorgan, AjitVarki, Eelcode Koning, SørgeKelm, KathrinMaedler

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes
2017

Maria J LKracht, Mennovan Lummel, TatjanaNikolic, Antoinette MJoosten, SandraLaban, Arno Rvan der Slik, Peter Avan Veelen, FrançoiseCarlotti, Eelco J Pde Koning, Rob CHoeben, ArnaudZaldumbide, Bart ORoep

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes
2017

NielsBusse, FedericoParoni, Sarah JRichardson, Jutta ELaiho, MaaritOikarinen, GunFrisk, HeikkiHyöty, Eelcode Koning, Noel GMorgan, KathrinMaedler

A Single-Cell Transcriptome Atlas of the Human Pancreas
2016

Mauro JMuraro, GitanjaliDharmadhikari, DominicGrün, NathalieGroen, TimDielen, ErikJansen, Leonvan Gurp, Marten AEngelse, FrancoiseCarlotti, Eelco J Pde Koning, Alexandervan Oudenaarden

Sequential intravital imaging reveals in vivo dynamics of pancreatic tissue transplanted under the kidney capsule in mice
2016

Léonvan Gurp, Cindy J MLoomans, Pim Pvan Krieken, GitanjaliDharmadhikari, ErikJansen, Femke C A SRingnalda, EvelyneBeerling, Jaccovan Rheenen, Eelco J Pde Koning

A Retrievable, Efficacious Polymeric Scaffold for Subcutaneous Transplantation of Rat Pancreatic Islets
2016

Alexandra MSmink, Don THertsig, LeendertSchwab, Aart Avan Apeldoorn, Eelcode Koning, Marijke MFaas, Bart Jde Haan, Paulde Vos

Hybrid Polycaprolactone/Alginate Scaffolds Functionalized with VEGF to Promote de Novo Vessel Formation for the Transplantation of Islets of Langerhans
2016

GiuliaMarchioli, Andrea DiLuca, Eelcode Koning, MartenEngelse, Clemens AVan Blitterswijk, MarcelKarperien, Aart AVan Apeldoorn, LorenzoMoroni

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
2016

DominicGrün, Mauro JMuraro, Jean-CharlesBoisset, KayWiebrands, AnnaLyubimova, GitanjaliDharmadhikari, Maaikevan den Born, Johanvan Es, ErikJansen, HansClevers, Eelco J Pde Koning, Alexandervan Oudenaarden

Distinct activation of primary human BDCA1(+) dendritic cells upon interaction with stressed or infected beta cells
2016

B. M.Schulte, E. D.Kers-Rebel, R.Bottino, J. D.Piganelli, J. M.Galama, M. A.Engelse, E. J.de Koning, G. J.Adema