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Key publications

Drost, J, van Jaarsveld, R.H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A.,Sachs, N., Overmeer, R.M., Offerhaus, G.J., Begthel, H. Korving, J., van de Wetering, M., Schwank, G. Logtenberg, M., Cuppen, E., Snippert, H.J., Medema, J.P., Kops, G. J. P. L., Clevers, H. Sequential cancer mutations in cultured human intestinal stem cells. Nature 521: 43-47 (2015)

van de Wetering, M., Francies, H.E., Francis, J.M., Bounova, G., Iorio, F., Pronk, A., van Houdt, W., van Gorp, J., Taylor-Weiner, A., Kester, L., McLaren-Douglas, A., Blokker, J., Jaksani, S., Bartfeld, S., Volckman, R., van Sluis, P., Li, V.S.W., Seepo, S., Sekhar Pedamallu, C., Cibulskis, C., Carter, S.L., McKenna, A., Lawrence, M.S., Lichtenstein, L., Stewart, C., Koster, J., Versteeg, R., van Oudenaarden, A., Saez-Rodriguez, J., Vries, R.G.J., Getz, G., Wessels, L., Stratton, M.R., McDermott, U., Meyerson, M., Garnett, M.J., Clevers, H. Prospective derivation of a ‘Living Organoid Biobank’ of colorectal cancer patients.
Cell 161: 933-945 (2015)

Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M., Ellis, E., van Wenum, M., Fuchs, S., de Ligt, J., van de Wetering, M., Sasaki, N., Boers, S., Kemperman, H., de Jonge, J. IJzermans, J., Niewenhuis, E., Hoekstra, R., Strom, S., Vries, R., van der Laan, L., Cuppen, E., Clevers, H. Long-term culture of genome-stable bipotent stem cells from adult human live. Cell 160: 299-312 (2015)

Sato, T., Vries, R., Snippert, H., van de Wetering, M., Barker, N., Stange, D., van Es, J., Abo, A., Kujala, P., Peters, P., Clevers, H. Single lgr5 gut stem cells build crypt-villus structures in vitro without a stromal niche. Nature 459 : 262-265 (2009)

Barker, N., van Es, J.H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Korving, J., Begthel, H., Peters, P.C., Clevers, H. Identification of stem cells in small intestine and colon by a marker gene LGR5. Nature 449: 1003-1007 (2007)

All publications

IκBNS enhances T follicular helper cell differentiation and function as downstream of Ascl2
2016

JunichiHosokawa, KotaroSuzuki, KazuyukiMeguro, ShigeruTanaka, YukoMaezawa, AkiraSuto, LisaFujimura, AkemiSakamoto, HansClevers, OsamuOhara, HiroshiNakajima

Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells
2016

PleunHombrink, ChristinaHelbig, Ronald ABacker, BerberPiet, Anna EOja, ReginaStark, GisoBrasser, AldoJongejan, René EJonkers, BenjaminNota, OnurBasak, Hans CClevers, Perry DMoerland, DerkAmsen, René A Wvan Lier

Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
2016

ZacharySteinhart, ZvezdanPavlovic, MeghaChandrashekhar, TraverHart, XiaoweiWang, XiaoyuZhang, MélanieRobitaille, Kevin RBrown, SrideviJaksani, RenéOvermeer, Sylvia FBoj, JarrettAdams, JamesPan, HansClevers, SachdevSidhu, JasonMoffat, StéphaneAngers

Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells
2016

OnurBasak, JoepBeumer, KayWiebrands, HiroshiSeno, Alexandervan Oudenaarden, HansClevers

Designer matrices for intestinal stem cell and organoid culture
2016

NikolceGjorevski, NormanSachs, AndreaManfrin, SonjaGiger, Maiia EBragina, PalomaOrdóñez-Morán, HansClevers, Matthias PLutolf

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
2016

Carla SVerissimo, René MOvermeer, BasPonsioen, JarnoDrost, SanderMertens, IngridVerlaan-Klink, Bastiaan vanGerwen, Mariekevan der Ven, Marc van deWetering, David AEgan, RenéBernards, HansClevers, Johannes LBos, Hugo JSnippert

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research
2016

Paul WTetteh, KaiKretzschmar, HarryBegthel, Maaikevan den Born, JeroenKorving, Folkert H MMorsink, HennerFarin, Johan Hvan Es, G Johan AOfferhaus, HansClevers

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration
2016

JoepBeumer, HansClevers

Tissue-specific mutation accumulation in human adult stem cells during life
2016

FrancisBlokzijl, Joepde Ligt, MyrtheJager, ValentinaSasselli, SophieRoerink, NobuoSasaki, MeritxellHuch, SanderBoymans, EwartKuijk, PjotrPrins, Isaac JNijman, InigoMartincorena, MichalMokry, Caroline LWiegerinck, SabineMiddendorp, ToshiroSato, GeraldSchwank, Edward E SNieuwenhuis, Monique M AVerstegen, Luc J Wvan der Laan, Jeroende Jonge, Jan N MIJzermans, Robert GVries, Marcvan de Wetering, Michael RStratton, HansClevers, EdwinCuppen, Rubenvan Boxtel

Organoids
2016

KaiKretzschmar, HansClevers

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
2016

LauraBroutier, AmandaAndersson-Rolf, Christopher JHindley, Sylvia FBoj, HansClevers, Bon-KyoungKoo, MeritxellHuch

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon
2016

NobuoSasaki, NormanSachs, KayWiebrands, Saskia I JEllenbroek, AriannaFumagalli, AnnaLyubimova, HarryBegthel, Maaikevan den Born, Johan Hvan Es, Wouter RKarthaus, Vivian S WLi, CarmenLópez-Iglesias, Peter JPeters, Jaccovan Rheenen, Alexandervan Oudenaarden, HansClevers

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation
2016

CarmenDominguez-Brauer, ZhenyueHao, Andrew JElia, Jérôme MFortin, RobertNechanitzky, Patrick MBrauer, YiSheng, Miyeko DMana, Iok In ChristineChio, JillianHaight, AaronPollett, RobertCairns, LeanneTworzyanski, SatoshiInoue, ColinReardon, AnaMarques, JenniferSilvester, Maureen ACox, AndrewWakeham, Omer HYilmaz, David MSabatini, Johan Hvan Es, HansClevers, ToshiroSato, Tak WMak

Who Is in the Driver's Seat
2016

JarnoDrost, HansClevers

Analysis of neural crest-derived clones reveals novel aspects of facial development
2016

MarketaKaucka, EvgenyIvashkin, DanielGyllborg, TomasZikmund, MarketaTesarova, JozefKaiser, MengXie, JulianPetersen, VassilisPachnis, Silvia KNicolis, TianYu, PaulSharpe, ErnestArenas, HjalmarBrismar, HansBlom, HansClevers, UeliSuter, Andrei SChagin, KajFried, AndreasHellander, IgorAdameyko

Organoid biobanking
2016

Sarah NBoers, Johannes Jmvan Delden, HansClevers, Annelien LBredenoord

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis
2016

Johanna FDekkers, GitteBerkers, EvelienKruisselbrink, AnnelotteVonk, Hugo Rde Jonge, Hettie MJanssens, InezBronsveld, Eduard Avan de Graaf, Edward E SNieuwenhuis, Roderick H JHouwen, Frank PVleggaar, Johanna CEscher, Yolanda Bde Rijke, Christof JMajoor, Harry G MHeijerman, Karin Mde Winter-de Groot, HansClevers, Cornelis Kvan der Ent, Jeffrey MBeekman

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
2016

DominicGrün, Mauro JMuraro, Jean-CharlesBoisset, KayWiebrands, AnnaLyubimova, GitanjaliDharmadhikari, Maaikevan den Born, Johanvan Es, ErikJansen, HansClevers, Eelco J Pde Koning, Alexandervan Oudenaarden

RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation
2016

Helen H NYan, Jeffrey C WLai, Siu LunHo, Wai KeungLeung, Wai LunLaw, Janet F YLee, Anthony K WChan, Wai YinTsui, Annie S YChan, Bernard C HLee, Sarah S KYue, Alice H YMan, HansClevers, Siu TsanYuen, Suet YiLeung

Modeling Development and Disease with Organoids
2016

HansClevers