Hans Clevers

Hans Clevers is groepsleider bij het Hubrecht Instituut voor ontwikkelingsbiologie en stamcelonderzoek en professor Molecular Genetics bij het Universiteit Medisch Centrum Utrecht en de Universiteit Utrecht. Tevens is hij wetenschappelijk directeur van het Prinses Máxima Centrum voor kinderoncologie.

De Clevers groep bestudeert de biologie van Wnt-signalering tijdens vernieuwing van cellen in de darm en bij kanker, ontdekte dat Lgr5 een marker is voor volwassen stamcellen in diverse volwassen weefsels en ontwikkelde een methode om deze Lgr5-positieve cellen uit te groeien tot mini-orgaantjes, zogenaamde organoïden. Deze worden gebruikt om de biologie en ontwikkeling te bestuderen van het orgaan waarvan ze afkomstig zijn. Bovendien stellen organoïden uit tumoren ons in staat om het ontstaan van kanker te bestuderen, drugscreenings uit te voeren en patiëntspecifieke behandelingen te testen (personalized medicine).

Download his C.V. here (.pdf)

Contact: h.clevers(at)hubrecht.eu

Functies, lidmaatschappen, prijzen en onderscheidingen

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Scientific Training/positions

1982 Msc Biology, Utrecht University

1984 MD, Utrecht University

1985 PhD, department of Clinical Immunology, Utrecht University

1985 – 1989 Research Fellow in Pathology, Dana-Farber Cancer Institute, Harvard Medical School

1989 – 1991 Assistant professor, department of Clinical Immunology, UMC Utrecht

1991 – 2002 Professor and chairman, dept. of Immunology, UMC Utrecht and University of Utrecht

2002 – 2012 Director Hubrecht Institute, Developmental Biology and Stem Cell Research

2002 – Professor of Molecular Genetics, UMC Utrecht and University of Utrecht

2002 – Honorary professor at Changsha-Hunan, China

2012 – 2015 President of the Royal Netherlands Academy of Sciences (KNAW)

2012 – Groupleader Hubrecht Institute, Developmental Biology and Stem Cell Research

2014 – Director and cofounder of Foundation Hubrecht Organoid Technologies (HUB)

2015 – Director Research of the Princess Maxima Center for pediatric oncology

Memberships

2017 President of the International Society for Stem Cell Research (ISSCR)

2017 – Member of the Orden Pour le Mérite für Wissenschaften und Künste

2016 – Member the Scientific Advisory Board of Kallyope Inc.

2016 – Member the Scientific Advisory Board of Surrozen, Inc.

2016 – Member the Scientific Advisory Board of Decibel Therapeutics, Inc.

2016 – Member of the Scientific Advisory Board of the Francis Crick Institute

2016 – Foreign Associate of the Academie des Sciences de I’Institut de France

2015 – Member of the Scientific Advisory Board of the Research Institute of Molecular Pathology (IMP), Vienna

2014 – Foreign Associate of the US National Academy of Sciences

2012 – Member of the American Academy of Arts and Sciences

2012 – Member of the ‘Koninklijke Hollandsche Maatschappij der Wetenschappen’
(The Royal Holland Society of Sciences and Humanities)

2009 – Member of the Academia Europaea

2007 – Member of the National Scientific Advisory Board NKI-AVL

2006 – Member of the American Association for Cancer Research (AACR)

2006 – 2008 President of the International Society of Differentiation (ISD)

2005 – 2015 Member of the Scientific Advisory Board of the Swiss Institute for Experimental Cancer Research (ISREC)

2004 – Member of the International Society for Stem Cell Research (ISSCR)

2000 – Member of the Royal Netherlands Academy of Sciences (KNAW)

1999 – Member European Molecular Biology Organisation (EMBO)

Prizes and awards

2016 The Ilse & Helmut Wachter award

2016 Swammerdam medaille (Het Genootschap ter Bevordering van Natuur-, Genees- en Heelkunde)

2016 The Körber European Science Prize

2016 Kazemi Award for Research Excellence in Bio-Medicine

2016 the Academy Professor Prize of the KNAW

2015 McEwen Award for Innovation

2014 National Icon of the Netherlands

2014 Struyvenberg European Society for Clinical Investigation (ESCI) medal

2014 Fellow of the AACR Academy

2014 TEFAF Oncology Chair 2014

2014 Massachusetts General Hospital Award in Cancer Research

2013 The Breakthrough Prize in Life Sciences

2012 Ridder in de Orde van de Nederlandse Leeuw

2012 The Heineken Prize for Medicine

2012 William Beaumont prize of the American Gastroenterology Association

2012 Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize

2011 Kolff prize

2011 The Ernst Jung Medical Award

2010 The United European Gastroenterology Federation (UEGF) Research Prize

2009 The Queen Wilhelmina Dutch Cancer Society Award

2008 Meyenburg Cancer Research Award

2008 Josephine Nefkens Prize for Cancer Research (Erasmus MC, Rotterdam)

2006 Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research

2005 Katharine Berkan Judd Award

2005 the French honor of “Chevalier de la Legion d’Honneur”

2005 the Science and Society Prize

2004 Louis-Jeantet Prize for Medicine

2001 Spinoza-award

2000 Catharijne-prize for medical science

Team membersClevers groep

Veerle Geurts

Technician

Veerle Geurts

Roksan Franko

Student

Marrit Putker

Postdoc

Jens Puschhof

PhD student

Sigrid Kolders

Technician

Dymph Klay

PhD student

Florijn Dekkers

Postdoc

Florijn Dekkers

Talya Dayton

Postdoc

Georg Busslinger

PhD student

Jochem Bernink

Postdoc

Yotam Bar-Ephraim

Postdoc

Marie Bannier

PhD student

Marie Bannier

Kadi Lõhmussaar

PhD Student

Carola Ammerlaan

Technician

Yoshiyuki Tsukamoto

Postdoc

Tomohiro Mizutani

Postdoc

Evelien de Jongh

Technician

Georg Busslinger

Postdoc

Huili Hu

Postdoc

Joep Beumer

PhD student

Kim Boonekamp

PhD student

Lena Böttinger

Postdoc

Priyanca Asra

Technician

Jasper Mullenders

postdoc

Yorick Post

PhD Students

Jeroen Korving

Lab Assistent

Frans Schutgens

PhD Student

Else Driehuis

PhD Student

Angelos Papaspyropoulos

Postdoc

Devanjali Dutta

Postdoc

Onur Basak

Postdoc

Oded Kopper

Postdoc

Kai Kretzschmar

Postdoc

Inha Heo

Postdoc

Helmut Gehart

Postdoc

Else Driehuis

PhD student

Benedetta Artegiani

Postdoc

Anjali Balgobind

Technician

Benaissa El Haddouti

Technician

Karien Hamer

Technician

Maaike van den Born

Technician

Harry Begthel

Lab Assistant

Laura Zeinstra

Lab Assistant

Stieneke van den Brink

Lab Assistant

Wim de Lau

Senior Researcher

Wim de Lau

Johan van Es

Senior Researcher

Johan van Es

Hans Clevers

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Onderzoek

Clevers: Lgr5 stem cells, Wnt signaling & cancer

Oorspronkelijk gericht op T lymfocyt transcriptiefactoren, kloneerden we Tcf1 in 1991. Door de ontdekking dat Tcf factoren de eindeffectoren zijn van Wnt signalering, pasten we onze interesses aan in de richting van de biologie van Wnt signalering in zelfvernieuwing en kanker van de darm. We identificeerden een serie volwassen stamcellen met de nieuwe Lgr5 marker en technologieën voor het langdurig kweken van deze stamcellen als epitheliale organoïden, wat onze huidige focus van onderzoek is.

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Key publications

Drost, J, van Jaarsveld, R.H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A.,Sachs, N., Overmeer, R.M., Offerhaus, G.J., Begthel, H. Korving, J., van de Wetering, M., Schwank, G. Logtenberg, M., Cuppen, E., Snippert, H.J., Medema, J.P., Kops, G. J. P. L., Clevers, H. Sequential cancer mutations in cultured human intestinal stem cells. Nature 521: 43-47 (2015)

van de Wetering, M., Francies, H.E., Francis, J.M., Bounova, G., Iorio, F., Pronk, A., van Houdt, W., van Gorp, J., Taylor-Weiner, A., Kester, L., McLaren-Douglas, A., Blokker, J., Jaksani, S., Bartfeld, S., Volckman, R., van Sluis, P., Li, V.S.W., Seepo, S., Sekhar Pedamallu, C., Cibulskis, C., Carter, S.L., McKenna, A., Lawrence, M.S., Lichtenstein, L., Stewart, C., Koster, J., Versteeg, R., van Oudenaarden, A., Saez-Rodriguez, J., Vries, R.G.J., Getz, G., Wessels, L., Stratton, M.R., McDermott, U., Meyerson, M., Garnett, M.J., Clevers, H. Prospective derivation of a ‘Living Organoid Biobank’ of colorectal cancer patients.
Cell 161: 933-945 (2015)

Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M., Ellis, E., van Wenum, M., Fuchs, S., de Ligt, J., van de Wetering, M., Sasaki, N., Boers, S., Kemperman, H., de Jonge, J. IJzermans, J., Niewenhuis, E., Hoekstra, R., Strom, S., Vries, R., van der Laan, L., Cuppen, E., Clevers, H. Long-term culture of genome-stable bipotent stem cells from adult human live. Cell 160: 299-312 (2015)

Sato, T., Vries, R., Snippert, H., van de Wetering, M., Barker, N., Stange, D., van Es, J., Abo, A., Kujala, P., Peters, P., Clevers, H. Single lgr5 gut stem cells build crypt-villus structures in vitro without a stromal niche. Nature 459 : 262-265 (2009)

Barker, N., van Es, J.H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Korving, J., Begthel, H., Peters, P.C., Clevers, H. Identification of stem cells in small intestine and colon by a marker gene LGR5. Nature 449: 1003-1007 (2007)

All publications

IκBNS enhances T follicular helper cell differentiation and function as downstream of Ascl2
2016 in21267

JunichiHosokawa, KotaroSuzuki, KazuyukiMeguro, ShigeruTanaka, YukoMaezawa, AkiraSuto, LisaFujimura, AkemiSakamoto, HansClevers, OsamuOhara, HiroshiNakajima

Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells
2016 in21315

PleunHombrink, ChristinaHelbig, Ronald ABacker, BerberPiet, Anna EOja, ReginaStark, GisoBrasser, AldoJongejan, René EJonkers, BenjaminNota, OnurBasak, Hans CClevers, Perry DMoerland, DerkAmsen, René A Wvan Lier

Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
2016 in15819

ZacharySteinhart, ZvezdanPavlovic, MeghaChandrashekhar, TraverHart, XiaoweiWang, XiaoyuZhang, MélanieRobitaille, Kevin RBrown, SrideviJaksani, RenéOvermeer, Sylvia FBoj, JarrettAdams, JamesPan, HansClevers, SachdevSidhu, JasonMoffat, StéphaneAngers

Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells
2016 in6100153018

OnurBasak, JoepBeumer, KayWiebrands, HiroshiSeno, Alexandervan Oudenaarden, HansClevers

Designer matrices for intestinal stem cell and organoid culture
2016 in21206

NikolceGjorevski, NormanSachs, AndreaManfrin, SonjaGiger, Maiia EBragina, PalomaOrdóñez-Morán, HansClevers, Matthias PLutolf

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
2016 in21100242814

Carla SVerissimo, René MOvermeer, BasPonsioen, JarnoDrost, SanderMertens, IngridVerlaan-Klink, Bastiaan vanGerwen, Mariekevan der Ven, Marc van deWetering, David AEgan, RenéBernards, HansClevers, Johannes LBos, Hugo JSnippert

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research
2016 in21121

Paul WTetteh, KaiKretzschmar, HarryBegthel, Maaikevan den Born, JeroenKorving, Folkert H MMorsink, HennerFarin, Johan Hvan Es, G Johan AOfferhaus, HansClevers

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration
2016 in14090

JoepBeumer, HansClevers

Tissue-specific mutation accumulation in human adult stem cells during life
2016 in21206

FrancisBlokzijl, Joepde Ligt, MyrtheJager, ValentinaSasselli, SophieRoerink, NobuoSasaki, MeritxellHuch, SanderBoymans, EwartKuijk, PjotrPrins, Isaac JNijman, InigoMartincorena, MichalMokry, Caroline LWiegerinck, SabineMiddendorp, ToshiroSato, GeraldSchwank, Edward E SNieuwenhuis, Monique M AVerstegen, Luc J Wvan der Laan, Jeroende Jonge, Jan N MIJzermans, Robert GVries, Marcvan de Wetering, Michael RStratton, HansClevers, EdwinCuppen, Rubenvan Boxtel

Organoids
2016 in18525

KaiKretzschmar, HansClevers

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
2016 in5800207366

LauraBroutier, AmandaAndersson-Rolf, Christopher JHindley, Sylvia FBoj, HansClevers, Bon-KyoungKoo, MeritxellHuch

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon
2016 in21121

NobuoSasaki, NormanSachs, KayWiebrands, Saskia I JEllenbroek, AriannaFumagalli, AnnaLyubimova, HarryBegthel, Maaikevan den Born, Johan Hvan Es, Wouter RKarthaus, Vivian S WLi, CarmenLópez-Iglesias, Peter JPeters, Jaccovan Rheenen, Alexandervan Oudenaarden, HansClevers

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation
2016 in6100153018

CarmenDominguez-Brauer, ZhenyueHao, Andrew JElia, Jérôme MFortin, RobertNechanitzky, Patrick MBrauer, YiSheng, Miyeko DMana, Iok In ChristineChio, JillianHaight, AaronPollett, RobertCairns, LeanneTworzyanski, SatoshiInoue, ColinReardon, AnaMarques, JenniferSilvester, Maureen ACox, AndrewWakeham, Omer HYilmaz, David MSabatini, Johan Hvan Es, HansClevers, ToshiroSato, Tak WMak

Who Is in the Driver's Seat
2016 in18606

JarnoDrost, HansClevers

Analysis of neural crest-derived clones reveals novel aspects of facial development
2016

MarketaKaucka, EvgenyIvashkin, DanielGyllborg, TomasZikmund, MarketaTesarova, JozefKaiser, MengXie, JulianPetersen, VassilisPachnis, Silvia KNicolis, TianYu, PaulSharpe, ErnestArenas, HjalmarBrismar, HansBlom, HansClevers, UeliSuter, Andrei SChagin, KajFried, AndreasHellander, IgorAdameyko

Organoid biobanking
2016 in22088

Sarah NBoers, Johannes Jmvan Delden, HansClevers, Annelien LBredenoord

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis
2016 in19700174677

Johanna FDekkers, GitteBerkers, EvelienKruisselbrink, AnnelotteVonk, Hugo Rde Jonge, Hettie MJanssens, InezBronsveld, Eduard Avan de Graaf, Edward E SNieuwenhuis, Roderick H JHouwen, Frank PVleggaar, Johanna CEscher, Yolanda Bde Rijke, Christof JMajoor, Harry G MHeijerman, Karin Mde Winter-de Groot, HansClevers, Cornelis Kvan der Ent, Jeffrey MBeekman

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
2016 in6100153018

DominicGrün, Mauro JMuraro, Jean-CharlesBoisset, KayWiebrands, AnnaLyubimova, GitanjaliDharmadhikari, Maaikevan den Born, Johanvan Es, ErikJansen, HansClevers, Eelco J Pde Koning, Alexandervan Oudenaarden

RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation
2016 in28366

Helen H NYan, Jeffrey C WLai, Siu LunHo, Wai KeungLeung, Wai LunLaw, Janet F YLee, Anthony K WChan, Wai YinTsui, Annie S YChan, Bernard C HLee, Sarah S KYue, Alice H YMan, HansClevers, Siu TsanYuen, Suet YiLeung

Modeling Development and Disease with Organoids
2016 in18434

HansClevers