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Key publications

Tessadori, F., Noël, E.S., Rens, E.G., Magliozzi, R., Evers-van Gogh, I.J.A., Guardavaccaro, D., Merks, R.M.H. and Bakkers, J.Nodal signalling range is regulated by proprotein convertase-mediated secretion. Dev. Celldoi:10.1016/j.devcel.2014.12.014

Junker, J.P.*, Noël, E.S*., Guryev, V., Peterson, K.A., Shah, G., Huisken, J., McMahon, A.P., Berezikov, E., Bakkers, J*. and van Oudenaarden, A.* (2014) Genome-wide RNA tomography in the zebrafish embryo. Cell159(3): 662-675

Chetaille, P.*, Côté, j.*, Burkhard, S.*, Houde, C., Preuss, C., Piché, J.,Gosset, N., Leclerc, S., Wünnemann, F., Cameron, M., Castilloux, J., Thibeault, M., Gagnon, C., Galli, A., Tuck, A., Hickson, G., Amine, N., Boufaied, I., Lemyre, E.,Santa Barbara, P., Faure, S., Jonzon, A., Dietz, H., Gallo-McFarlane, E., Benson, W., Zhan, S.H., Shen, Y., Jomphe, M., Jones, S.J.M., Bakkers, J., and Andelfinger, G.(2014) A human dysrhythmia syndrome affecting heart and gut is associated with mutations in SGOL1.Nat. Genet.46(11):1245-1249

Noël ES, Verhoeven M, Lagendijk AK, Tessadori F, Smith K, Choorapoikayil S, den Hertog J and Bakkers J. (2013) A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality. Nat. Commun4:2754

Mugoni, V., Postel, R., Catanzaro, V., De Luca, E., Turco, E., Digilio, G., Silengo, Murphy, M.P., Medana, C., L., Stainier, D.Y.R., Bakkers, J. and Santoro, M.M. (2013) Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis. Cell 152; 504-518

All publications

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability
2016

Elisabeth MLodder, PasquelenaDe Nittis, Charlotte DKoopman, WojciechWiszniewski, Carolina FischingerMoura de Souza, NajimLahrouchi, NicolasGuex, ValerioNapolioni, FedericoTessadori, LeanderBeekman, Eline ANannenberg, LamiaeBoualla, Nico ABlom, Wimde Graaff, MaartenKamermans, DarioCocciadiferro, NatasciaMalerba, BarbaraMandriani, Zeynep HandeCoban Akdemir, Richard JFish, Mohammad KEldomery, IlhamRatbi, Arthur A MWilde, Teunde Boer, William FSimonds, MargueriteNeerman-Arbez, V ReidSutton, FernandoKok, James RLupski, AlexandreReymond, Connie RBezzina, JeroenBakkers, GiuseppeMerla

Rare novel variants in the ZIC3 gene cause X-linked heterotaxy
2016

Aimee D CPaulussen, AnjaSteyls, JoVanoevelen, Florence Hjvan Tienen, Ingrid P CKrapels, Godelieve RfClaes, SonjaChocron, CroolVelter, Gita MTan-Sindhunata, CatarinaLundin, IreneValenzuela, BalintNagy, IbenBache, Lisa LethMaroun, KristiinaAvela, Han GBrunner, Hubert J MSmeets, JeroenBakkers, Arthurvan den Wijngaard

Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity
2016

Dragana JJosifova, Glen RMonroe, FedericoTessadori, Estherde Graaff, Bertvan der Zwaag, Sarju GMehta, MagdalenaHarakalova, Karen JDuran, Sanne M CSavelberg, Isaäc JNijman, HeinzJungbluth, Casper CHoogenraad, JeroenBakkers, Nine VKnoers, Helen VFirth, Philip LBeales, Gijsvan Haaften, Mieke Mvan Haelst, DDD Study

A zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals its Specific Role in Laterality Organ Function
2016

Emily SNoël, Tarek SMomenah, KhalidAl-Dagriri, AbdulrahmanAl-Suwaid, SafarAl-Shahrani, HuiJiang, SvenWillekers, Yara YOostveen, SonjaChocron, Alex VPostma, Zahurul ABhuiyan, JeroenBakkers

Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration
2016

Chi-ChungWu, FabianKruse, Mohankrishna DalvoyVasudevarao, Jan PhilippJunker, David CZebrowski, KristinFischer, Emily SNoël, DominicGrün, EugeneBerezikov, Felix BEngel, Alexandervan Oudenaarden, GilbertWeidinger, JeroenBakkers

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2
2016

BilgeSan, Naomi DChrispijn, NadineWittkopp, Simon Jvan Heeringen, Anne KLagendijk, MarcoAben, JeroenBakkers, René FKetting, Leonie MKamminga

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability
2016

Elisabeth MLodder, PasquelenaDe Nittis, Charlotte DKoopman, WojciechWiszniewski, Carolina FischingerMoura de Souza, NajimLahrouchi, NicolasGuex, ValerioNapolioni, FedericoTessadori, LeanderBeekman, Eline ANannenberg, LamiaeBoualla, Nico ABlom, Wimde Graaff, M.Kamermans, DarioCocciadiferro, NatasciaMalerba, BarbaraMandriani, Zeynep Hande CobanAkdemir, Richard JFish, Mohammad KEldomery, IlhamRatbi, Arthur A MWilde, Teunde Boer, William FSimonds, MargueriteNeerman-Arbez, V ReidSutton, FernandoKok, James RLupski, AlexandreReymond, Connie RBezzina, JeroenBakkers, GiuseppeMerla

Tomo-seq
2016

FKruse, J PJunker, Avan Oudenaarden, JBakkers

αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish
2016

Mitchell K LHan, EstebanHoijman, EmilyNöel, LaurenceGarric, JeroenBakkers, Johande Rooij

Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes
2015

ShannonMarchegiani, TaylorDavis, FedericoTessadori, Gijsvan Haaften, FrancescoBrancati, AlexanderHoischen, HaigenHuang, EliseValkanas, BarbaraPusey, DennySchanze, HankaVenselaar, Anneke TVulto-van Silfhout, Lynne AWolfe, Cynthia JTifft, Patricia MZerfas, GiovannaZambruno, ArianaKariminejad, FarahnazSabbagh-Kermani, JaniceLee, Maria GTsokos, Chyi-Chia RLee, VictorFerraz, Eduarda Morganada Silva, Cathy AStevens, NathalieRoche, OliverBartsch, PeterFarndon, EvaBermejo-Sanchez, Brian PBrooks, ValerieMaduro, BrunoDallapiccola, Feliciano JRamos, Hon-Yin BrianChung, CédricLe Caignec, FabianaMartins, Witold KJacyk, LauraMazzanti, Han GBrunner, JeroenBakkers, ShuoLin, May Christine VMalicdan, Cornelius FBoerkoel, William AGahl, Bert B Ade Vries, Mieke Mvan Haelst, MartinZenker, Thomas CMarkello

Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies
2015

CarolineRamspacher, EmilySteed, FrancescoBoselli, RitaFerreira, NathalieFaggianelli, StéphaneRoth, CoralieSpiegelhalter, NadiaMessaddeq, LeTrinh, MichaelLiebling, NikhilChacko, FedericoTessadori, JeroenBakkers, JocelynLaporte, KarimHnia, JulienVermot

Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling
2015

InaStrate, FedericoTessadori, JeroenBakkers

Animal and in silico models for the study of sarcomeric cardiomyopathies
2015

Dirk JDuncker, JeroenBakkers, Bianca JBrundel, JeffRobbins, Jil CTardiff, LucieCarrier

Nodal signaling range is regulated by proprotein convertase-mediated maturation
2015

FedericoTessadori, Emily SNoël, Elisabeth GRens, RobertoMagliozzi, Inkie J AEvers-van Gogh, DanieleGuardavaccaro, Roeland M HMerks, JeroenBakkers

GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish
2015

VanesaJiménez-Amilburu, SusanneJong-Raadsen, JeroenBakkers, Herman PSpaink, RubénMarín-Juez

Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm
2014

PhilippeChetaille, ChristophPreuss, SiljaBurkhard, Jean-MarcCôté, ChristineHoude, JulieCastilloux, JessicaPiché, NatachaGosset, SéverineLeclerc, FlorianWünnemann, MaryseThibeault, CarmenGagnon, AntonellaGalli, ElizabethTuck, Gilles RHickson, NourEl Amine, InesBoufaied, EmmanuelleLemyre, Pascalde Santa Barbara, SandrineFaure, AndersJonzon, MichelCameron, Harry CDietz, ElenaGallo-McFarlane, D WoodrowBenson, ClaudiaMoreau, DamianLabuda, Shing HZhan, YaoqingShen, MichèleJomphe, Steven J MJones, JeroenBakkers, GregorAndelfinger, FORGE Canada Consortium

Genome-wide RNA Tomography in the zebrafish embryo
2014

Jan PhilippJunker, Emily SNoël, VictorGuryev, Kevin APeterson, GopiShah, JanHuisken, Andrew PMcMahon, EugeneBerezikov, JeroenBakkers, Alexandervan Oudenaarden

Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish
2014

MonicaBonetti, JeroenPaardekooper Overman, FedericoTessadori, EmilyNoël, JeroenBakkers, Jeroenden Hertog

On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling
2013

M.Goudarzi, I.Strate, A.Paksa, A.K.Lagendijk, J.Bakkers, E.Raz

Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation
2013

A.K.Lagendijk, A.Szabo, R.M.Merks, J.Bakkers