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RASopathies are a group of human syndromes that are characterized by similar symptoms, including short stature, craniofacial defects, cardiac defects and enhanced susceptibility to cancer. RASopathies have in common that they are caused by activating mutations in factors of the RAS-MAPK signaling pathway. Previous work in our lab focused on the use of zebrafish to model RASopathies and particularly Noonan Syndrome (for example https://doi.org/10.7554/eLife.73040). This project is aimed at (i) development and characterization of genetic models of Noonan syndrome in zebrafish, generated using CRISPR/Cas9 technology, with focus on hematopoiesis and lymphangiogenesis, and (ii) analysis of small molecule inhibitors that may rescue developmental defects in zebrafish Noonan syndrome models.
RequirementsYou have a MSc degree in molecular biology, cell biology, developmental biology, molecular genetics or similar. Experience with zebrafish is not required. You have affinity with cellular signal transduction and with multidisciplinary research, ranging from the molecular to the organismal level.
About the Hubrecht Institute
The Hubrecht Institute is a research institute focusing on developmental and stem cell biology. At the institute, more than 20 research groups perform fundamental and multidisciplinary research, both in healthy systems and disease models. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW) and is located on the Utrecht Science Park ‘De Uithof’. Since 2008, the institute has been affiliated with the University Medical Center Utrecht, advancing the translation of research into clinical practice. The Hubrecht Institute has a partnership with the European Molecular Biology Laboratory (EMBL).
Terms of employment
Depending on education and experience the minimum salary is € 2.770,- and the maximum salary is € 3.539,- gross per month for a full-time appointment (scale P cao Nederlandse Universiteiten/KNAW). This is exclusive of 8% vacation allowance, 8.3% year-end bonus, travel allowance, internet allowance, home working allowance and pension accrual with ABP.
The KNAW offers its staff an excellent package of secondary benefits. A package that meets the different needs of employees depending on their stage of life, lifestyle or career ambitions. For example, by working an extra two hours a week, it is possible to increase the number of days off from 29 to 41 days a year (with full-time employment).
For a complete overview of the terms of employment, please refer to the web page: werken bij de KNAW.
Diversity & Inclusion
The KNAW considers a working environment in which everyone feels welcome and appreciated of great importance. A working environment in which attention is paid to individual quality and where development opportunities are paramount. Together we strive for an inclusive culture in which we embrace differences. We would therefore like to invite candidates who want to contribute to this through their background and experience. In the event of equal suitability, preference will be given to the candidate who thus enhances diversity within the Academy.
We will not respond to any supplier enquiries based on this job advertisement.
den Hertog group
Utrecht Science park