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The group of Dr. Matilde Galli currently has a vacancy for a
full time (38 hours/week)
To work on: Cell-cycle control in a multicellular context
Description of the project: Research over the past decades has uncovered the basic principles of the cell cycle, in which cells transition between phases of growth, DNA replication and division. However, most of our knowledge on cell-cycle control stems from research performed in individual cells, such as yeast or mammalian cells in culture, and surprisingly little is known about cell-cycle control in the context of a tissue environment, such as within an animal body. Our group studies how the cell cycle is controlled in a multicellular context, using the small nematode C. elegans as a model organism, as well as mammalian organoid cultures.
In this project, we are interested in understanding how cell-cycle decisions are made in an multicellular context: how do cells change their gene-expression profiles during the cell cycle and how do extracellular signals influence cell-cycle decisions? By using a combination of techniques, such as RNA-sequencing, chromatin profiling, long-term live imaging and genome editing, we aim to identify novel conserved mechanisms of cell-cycle control.
Requirements: We are seeking outstanding PhD candidates (Master of Science or equivalent qualification) with a strong background in cell biology, genetics and/or bioinformatics. The candidate should be passionate about biology, curious, and motivated to work in an ambitious and collaborative environment. Fluency in English is required. The application should include a letter of motivation, a CV with two references, and a short summary of your Master thesis.
Duration: 1 year with the possibility of an extension for three years after positive evaluation.
Starting date: Between December 2019 and February 2020
Salary: According to “CAO-Nederlandse Universiteiten” (CAO-NU) € 2.266,- in the first year, increasing to € 2.897,- in the fourth year, excluding 8% holiday allowance and an 8,3% year-end bonus. We offer an extensive package of fringe benefits.
Location: Utrecht Science Park, De Uithof.
Information: For additional information please contact Dr. M. Galli email@example.com or visit our websites: www.hubrecht.eu/research-groups/galli-group and www.gallilab.org
Interested? Please send your application including CV and contact details of two potential references, before November 30st, 2019 to firstname.lastname@example.org, stating vacancy HUBR-2019-16 in the subject line.
Any acquisition further to this advertisement will not be appreciated.
Utrecht Science Park