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van Rheenen group


Ellenbroek SI, van Rheenen J. (2014) Imaging hallmarks of cancer in living mice. Nature Reviews Cancer, 14(6): 406-18

Ritsma L*, Ellenbroek S*, Zomer A, Snippert H, de Sauvage F, Simons B, Clevers H, van Rheenen J, (2014) Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature, 507(7492):362-365

Alieva M, Ritsma L, Giedt RJ, Weissleder R, van Rheenen J, Imaging windows for long-term intravital imaging: general overview and technical insights, IntraVital, 3, e29917

van Golen RF, Reiniers MJ, Vrisekoop N, Zuurbier CJ, Olthof PB, van Rheenen J, Vangulik T, Parsons BJ, Heger M, (2014) The mechanisms and physiological relevance of glycocalyx degradation in hepatic ischemia/reperfusion injury. Antioxid Redox Signal. Dec 6.


Ritsma L, Vrisekoop N, van Rheenen (2013) In vivo imaging and histochemistry are combined in the cryosection labelling and intravital microscopy technique. Nat Commun., 4:2366

Fritz RD, Letzelter M, Reimann A, Martin K, Fusco L, Ritsma L, Ponsioen B, Fluri E, Schulte-Merker S, van Rheenen J, Pertz O (2013) A versatile toolkit to produce sensitive FRET biosensors to visualize signaling in time and space. Sci Signal, 23:6(285)

Janssen A, Beerling E, Medema R, van Rheenen J (2013) Intravital FRET imagign of tumor cell viablity and mitosis during chemotherapy. PLoS One, May 15, 895): e64029.

Manning CS, Jenkins R, Hooper S, Gerhardt H, Marais R, Adams S, Adams RH, van Rheenen J, Sahai E. (2013) Intravital imaging reveals conversion between distinct tumor vascular morpholgies and localized vascular response to Sunitinib, IntraVital, Vol 2, Issue 1

Zomer A, Ellenbroek SIJ, Ritsma L, Beerling E, Vrisekoop N, van Rheenen J (2013) Intravital imaging of Cancer Stem Cell Plasticity in Mammary tumors. Stem Cells, Mar;31(3):602-6. doi: 10.1002/stem.1296 .

Ritsma L, Steller EJA, Ellenbroek SIJ, Kranenburg O, Borel Rinkes IHM, van Rheenen (2013) Surgical implantation of the Abdominal Imaging Window for intravital imaging. Nat Protoc. 2013 Mar;8(3):583-94. doi: 10.1038/nprot.2013.026. Epub 2013 Feb 21

Bonapace L, Wyckoff J, Oertner T, van Rheenen J, Junt T, Bentires-Alj M. (2012) If You Don't Look, You Won't See: Intravital Multiphoton Imaging of Primary and Metastatic Breast Cancer. J. Mammary Gland Biol Neoplasia. May 12.

Ritsma L, Ponsoein B, van Rheenen J (2012) Intravital imaging of cell signaling in mice. IntraVital, 1:1, 1-9.

Ritsma, L.*, Steller, E.J.A.*, Beerling, E., Loomans, C.J.M., Zomer, A., Gerlach, C., Vrisekoop, N., Seinstra, D., van Gurp, L., Schäfer, R., Raats, D.A., de Graaff, A. Schumacher, T.N., de Koning, E.J.P. Borel Rinkes, I.H., Kranenburg, O. van Rheenen, J. (2012) Intravital Microscopy Through an Abdominal Imaging Window Reveals a Pre-Micrometastasis Stage During Liver Metastasis. Sci Transl Med 4, 158ra145.

Arriotti S, Beltman JB, Chodaczek G, Hoekstra ME, van Beek AE, Gomez-Eerland R, Ritsma L, van Rheenen J, Maree AF, Zal T, de Boer RJ, Haanen JB, Schumacher TN (2012) Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen. Proc. Natl Acad Sci USA, Nov 27; 109(48): 19739-44.

Zomer A, Beerling E, Vlug EJ, van Rheenen J. (2011) Real-time intravital imaging of cancer models. Clin Transl.Oncol. , 13(12):848-54.

Steller EJ, Ritsma L, Raats DA, Hoogwater FJ, Emmink BL, Govaert KM, Laoukili J, Borel Rinkes IH, van Rheenen J, Kranenburg O. (2011 )The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion. EMBO reports , Sep 1;12(9):931-7

Beerling E, Ritsma L, Vrisekoop N, Derksen PW, van Rheenen J. (2011) Intravital microscopy: new insights into metastasis of tumors. J Cell Sci. , Feb 1;124(Pt 3):299-310.

Jalink K, van Rheenen, J (2010) Nano-imaging of membrane topography affects interpretations in cell biology. Nat. Meth. 7:486.

Snippert HJ, van der Vlier LG, Sato T, van Es JH, van der Born M, Kroen-Veenboer C, Barker N, Klein AM, van Rheenen J, Simons BD, Clevers H. (2010) Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells, Cell, 143(1): 134-144

Jalink K., van Rheenen J. FilterFRET: quantitative imaging of sensitized emission. (2009) Laboratory Techniques in Biochemistry & Molecular Biology: FRET and FLIM imaging techniques.

van Rheenen J, Condeelis J., and Michael Glogauer (2009) A common cofilin activity cycle in invasive tumor cells and inflammatory cells. J. Cell Sci. , 122 (Pt 3): 305-311

Gligorijevic B, Kedrin D, Segall JE, Condeelis J, van Rheenen J. (2009) Dendra2 photoswitching through the Mammary Imaging Window, J. Vis. Exp, Jun 5;(28). pii: 1278. doi: 10.3791/1278.

Wolf K, Alexander S, Schacht V, Coussens LM, von Andrian UH, van Rheenen J, Deryugina E, Friedl P. Collaen-based cell migratio models in vitro and in vivo (2009) Semin Cell Dev Bio

Oser M, Yamaguchi H, Mader CC, Bravo-Cordero JJ, Arias M, Chen X, Desmarais V, van Rheenen J, Koleske AJ, Condeelis J. Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. (2009) J Cell Biol.  Aug 24;186(4):571-87.

Leyman S, Sidani M, Ritsma L, Waterschoot D, Eddy R, Dewitte D, Debeir O, Decaestecker C, Vandekerckhove J, van Rheenen J, Ampe C, Condeelis J, Van Troys M. Unbalancing the PI(4,5)P2-cofilin interaction impairs cell steering. (2009) Mol Biol Cell., Sep 9.

van den Bout I, van Rheenen J, van Angelen AA, de Rooij J, Wilhelmsen K, Jalink K, Divecha N, Sonnenberg A. (2008) Investigation into the mechanism regulating MRP localization. Exp Cell Res., 314(2): 330-41.

Raja WK, Cady NC, Castracane J, Gligorijevic B, van Rheenen J, Condeelis JS. (2008) The NANIVID: a new device for cancer cell migration studies. Proceedings of SPIE (Society for Optical Engineering)., 6859, 68591M

Kedrin D, Gligorijevic B, Wyckoff J, Verkusha VV, Condeelis J, Segall JE, van Rheenen J. (2008). Intravital imaging of metastatic behavior through a mammary imaging window. Nature Methods, (12):1019-21.

Bins A*., van Rheenen J.*$, Jalink K., Halstead J.R., Divecha N., Spencer D.M., Haanen J.B.A.G., Schumacher T.N.M. (2007) Schumacher Intravital imaging of fluorescent markers and FRET by DNA tattooing. BMC biotech.7:2. *corresponding author, $equal contribution

Kedrin D, van Rheenen J, Hernandez L, Condeelis J, Segall JE. (2007) Cell motility and cytoskeletal regulation in invasion and metastasis. J Mammary Gland Biol Neoplasia. 12(2-3): 143-52.

Wilhelmsen K, Litjens SH, Kuikman I, Margadant C, van Rheenen J, Sonnenberg A. (2007) Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption. Mol Biol Cell. 18(9): 3512-22.

van Rheenen J, Song X, van Roosmalen W, Cammer M, Chen X, Desmarais V, Yip SC, Backer JM, Eddy RJ, Condeelis JS. (2007) EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells. J Cell Biol., 179(6): 1247-59. Highlighted in Nat. Rev. Mol. Cell Biol., 9(2):91.

Stroeken P.J., Alvarez B., van Rheenen J., Wijnands Y.M., Geerts D., Jalink K., Roos E. (2006) Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane. J Cell Physiol., 208(3):620-8.

Halstead J.R., van Rheenen J., Snel M.H., Meeuws S., Mohammed S., D'Santos S., Heck A.J., Jalink K., Divecha N. (2006) A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis. Curr Biol., 16(18):1850-6.

Danen E.H.J., van Rheenen J., Franken W., Jalink K., Sonnenberg A. (2005) Integrin-specific regulation of focal contact dynamics, polarization, and migratory strategy. J. Cell Biol., 169: 512-526.

Zwart W., Griekspoor A., Kuyl C., Marsman M., van Rheenen J., Janssen H., Calafat J., van Jam M., Janssen L., van Lith M., Jalink K., Neefjes J. (2005) Spatial seperation of HLA-DM/HLA-DR interactions within MIIC and phagosomal immune escape, Immunity, 22: 221-233.

van Rheenen J., Achame E.M., Janssen H., Calafat J., Jalink K. (2005) PIP2 in rafts: a critical re-evaluation, EMBO J., 24: 1664-1673.

:van Rheenen J., Langeslag M., Jalink K. (2004) Correcting confocal acquisition to optimize imaging of fluorescence resonance energy transfer by sensitized emission. Biophys. J., 86: 2517-2529.

van Rheenen J., Jalink K. (2002) Agonist-induced PIP2 hydrolysis inhibits cortical actin dynamics: Regulation at a global but not at a micrometer scale. Mol. Biol. Cell, 13: 3257-3267

van Rheenen J., Jalink K. (2002) Reconstruction of the axial pointspread function: Imaging subresolution membrane folds. Imaging and Microscopy, 4: 46-48.

van Rheenen J., Jalink K. (2002) Visualizing the surface profile of the basal membrane with high precision. Bioforum International, 6: 246-249.
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