van Oudenaarden group

Systems biology of development & stem cells

The van Oudenaarden lab is using a combination of experimental, computational, and theoretical approaches to quantitatively understand decision‐making in single cells with a focus on questions in developmental and stem cell biology. We are particularly interested in how cells use gene networks to make robust decisions even in the presence of significant fluctuations in gene expression.

Starting in September 2012 we will start to build a new laboratory at the Hubrecht Institute. If you would enjoy working on fundamental and quantitative problems in biology, surrounded by an interdisciplinary group of people including biologists, physicists and engineers, please send an e-mail to Alexander van Oudenaarden.
Please include a CV and explain why you are interested in our group. We are interested in enthusiastic people with a wide range of backgrounds. We have openings for PhD and post-doctoral positions and also have a few positions available for non-tenure track senior researchers.

Key publications (5 recent)
Itzkovitz, S., Lyubimova, A., Blat, I.C., Maynard, M., van Es, J., Lees, J., Jacks, T., Clevers, H., van Oudenaarden, A. (2012) Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nature Cell Biology 14: 106-114.

Itzkovitz, S., Blat, I., Jacks, T., Clevers, H., van Oudenaarden, A. (2012) Optimality in the development of intestinal crypts. Cell, 148: 608-619.

Mukherji, S., Ebert, M.S., Zheng, G.X., Tsang, J.S., Sharp, P.A., van Oudenaarden, A.(2011) MicroRNAs can generate thresholds in target gene expression. Nature Genetics 43: 854-859.
 
Acar, M., Pando, B.F., Arnold, F.H., Elowitz, M.B., van Oudenaarden A. (2010) A general mechanism for network-dosage compensation in gene circuits. Science 329: 1656-1660.

Raj, A., Rifkin, S.A., Andersen, E., van Oudenaarden A. (2010) Variability in gene expression underlies incomplete penetrance. Nature 463: 913-918.

Publication list