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Schulte-Merker group


van Impel, A., Zhao, Z., Hermkens, D.M.A., Roukens, G., Fischer, J.C., Peterson-Maduro, J., Duckers, H., Ober, E.A., Ingham, P.W., and Schulte-Merker, S. (2014) Divergence of lymphatioc cell specification pathways between zebrafish and mice. Development, in press.

Ludovic Le Guen, Karpanen, T., Schulte, D., Harris, N.C., Koltowska, K., Roukens, G., Bower, N., van Impel, A., Stacker, S., Achen, M.G., Schulte-Merker, S.*, and Hogan, B.* (2014) Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis. Development, in press.  [*joint senior authors]

van de Pavert, S., Ferreira, M., Domingues, R.G., Ribeiro, H., Molenaar, R., Moreira-Santos, L., Almeida, F.F., Ibiza, S., Barbosa, I., Labão-Almeida, I., Goverse, G., Godinho-Silva, C., Konijn, T., Schooneman, D., O’Toole, T., Mizee, M., Habani, Y., Haak, E., Santori, F.R., Littman, D.R., Schulte-Merker, S., Dzierzak, E., Simas, J.P., Mebius, R.E.,  and Veiga-Fernandes, H. (2014) Maternal retinoids control type 3 innate lymphoid cells and set the immune fitness of the progeny. Nature, in press.

Coxam, B., Sabine, A., Bower, N.I., Smith, K.A., Pichol-Thievend, C., Skoczylas, R., Astin, J.W., Frampton, E., Jaquet, M., Crosier, P.S., Parton, R.G., Harvey, N.L., Petrova, T.V., Schulte-Merker, S., Francois, M., and Hogan, B.M. (2014) Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Reports, in press.

Kessels, M.Y., Huitema, L.F., Boeren, S., Kranenbarg, S., Schulte-Merker, S., van Leeuwen, J.L., and de Vries, S.C. (2014) Proteomics analysis of the zebrafish skeletal extracellular matrix. PLoS One 9(3):e90568. doi:10.1371

Mackay, E., Apschner, A., and Schulte-Merker, S. (2013) A Bone To Pick with Zebrafish. BoneKey, in press. doi:10.1038/bonekey.2013.179

van Impel, A. and Schulte-Merker, S. (2013) A Fisheye View on Lymphangiogenesis. In: Developmental Aspects of the Lymphatic Vascular System. Kiefer, F. and Schulte-Merker, S. (Eds.) Springer Press.

Postma, A.V., Alders, M., Sylva, M., Bilardo, C.M., Pajkrt, E., van Rijn, R.R., Schulte-Merker, S., Bulk, S., Stefanovic, S., Ilgun, A., Barnett, P., Mannens, M.M.A.M., Moorman, A.F.M., Oostra, R.J., and van Maarle, M.C. (2013). Mutations in the T gene cause a novel syndrome consisting of sacral agenesis, abnormal ossification of the vertebral bodies and a persistent notochordal canal. J Medical Genetics 51, 90-97.

Hägerling, R., Pollmann, C., Andreas, M., Schmidt, C., Nurmi, H., Adams, R.H., Alitalo. K.,  Andresen, V., Schulte-Merker, S., and Kiefer, F. (2013) A novel multi-step mechanism for inititial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J 32(5): 629-44.

Basten, S.G., Davis, E.E., Gillis, A.J., van Rooijen, E., Stoop, H., Babala, N., Logister, I., Heath, Z.G., Jonges, T.N., Katsanis, N., Voest, E.E., van Eeden, F.J., Medema, R.H., Ketting, R.F., Schulte-Merker, S., Looijenga, L.H., Giles, R.H. (2013) Mutations in LRRC50 Predipose Zebrafish and Humans to Seminomas. PLoS Genetics 9(4): e1003384.

Fritz, R.D., Letzelter, M., Reimann, A., Martin, K., Fusco, L., Ritsma, L., Ponsioen, B., Fluri, E., Schulte-Merker, S., van Rheenen, J., and Pertz, O., (2013). A versatile tool kit to produce sensitive FRET biosensors to visualize signaling in time and space. Science Signaling (6)285..

Helker, C.S.M., Schuermann, A., Karpanen, T., Zeuschner, D., Belting, H.-G., Affolter,M., Schulte-Merker, S., and Herzog, W. (2013). The Zebrafish Common Cardinal Veins Develop by a Novel Mechanism: 'Lumen Ensheathment'. Development 140 (13), 2776-86.

Gordon, K., Schulte, D., Brice, G., Simpson, M.A., Roukens, M.G., van Impel, A.W., Connell, F., Kalidas, K., Jefferey, S., Mortimer, P.S., Schulte-Merker, S., and Ostergaard, P. (2013) A mutation in VEGFC, a ligand for VEGFR3, is associated with autosomal-dominant Milroy-like primary lymphedema. Circulation Research 112(6), 956-60.

Huitema, L.F.A., Apschner, A., Logister, I., Spoorendonk, K.M., Bussmann, J., Hammond, C.L., and Schulte-Merker, S. (2012) Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish. PNAS 109 (52), 21372-7.

Mitchell, R.E., Huitema, L..F.A., Skinner, R..H.E., Brunt, L..H,  Severn, C.,Schulte-Merker, S. and Hammond C.L. (2012) New tools for studying osteoarthritis genetics in zebrafish. Osteoarthritis and Cartilage 21(2), 269-78.

Huitema, L.F.A., Renn, J., Logister, I., Waltz, S.E., Flik, G.,and Schulte-Merker, S. (2012) Macrophage stimulating protein is involved in skeletal mineralization and calcium homeostasis in zebrafish. FASEB Journal 26(10):4092-101.

Bart G.M.W. Weijts, Bakker, W.J., Cornelissen, P.W.A., Liang, K., Schaftenaar, F.H., Westendorp, B., de Wolf, C.A.C.M.T., Paciejewska, M., Scheele, C.L.G.J., Kent, L., Leone, G., Schulte-Merker, S., de Bruin, A. (2012) E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. EMBO Journal 31(19): 3871-84..

Tempel, D., de Boer, M., van Deel, E.D., Haasdijk, R.A., Duncker, D.J., Cheng, C., Schulte-Merker, S., and Duckers, H.J. (2012) Apelin enhances cardiac neovascularization after myocardial infarction by recruiting Aplnr+ circulating cells. Circulation Research 111(5), 585-98.

Wilkinson, R.N., Koudijs, M., Ingham, P.W., Patient, R.K., Schulte-Merker, S., and van Eeden, F.J.M. (2012) Hedgehog signalling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signalling in zebrafish. Blood 120 (2), 477-88.

Fiaz, A.W., Leon-Kloosterziel, K.M., Gort, G., Schulte-Merker, S., van Leeuwen, J.L., and Kranenbarg, S. (2012) Swim-training changes the spatio-temporal dynamics of skeletogenesis in zebrafish larvae (Danio rerio). PLoS One 7 (4): e34072.

Cheng, C., Haasdijk, R., Tempel, D., van de Kamp, E.H.M., Herpers, R., Bos, F., den Dekker, W.K., Blonden, L.A.J., de Jong, R., Bürgisser, P.E., Chifri, I., Biessen, E.A.L., Dimmeler, S., Schulte-Merker, S., and Duckers, H.J. (2012) Endothelial cell specific FGD5 involvement in vascular pruning defines neovessel fate in mice. Circulation 125(25), 3142-58.

Ostergaard, P., Simpson, M.A., Mendola, A., Vasudevan, P., Connell, F.C., van Impel, A., Moore, A.T., Loeys, B.L., Ghalamkarpour, A., Onoufriadis, A., Martinez-Corral, I., Devery, S., Leroy, J.G., van Laer, L., Singer, A., Bialer, M.G., McEntagart, M., Quarrell, O., Brice, G., Trembath, R.C., Schulte-Merker, S., Makinen, T., Vikkula, M., Mortimer, P.S., Mansour, S., and Jeffery, S. (2012). Mutations in KIF11 cause autosomal dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy. American J of Human Genetics 90 (2): 356-62.

Schulte‐Merker, S., Sabine, A., and Petrova, T. (2011).  Mechanisms of lymphatic vascular morphogenesis in development, physiology and human disease.  Journal of Cell Biology 193, 607-618.

Bos, F.L., Caunt, M., Peterson-Maduro, J., Planas-Paz, L., Kowalski, J., Karpanen, T., van Impel, A., Tong, R., Ernst, J.A., Korving, J., van Es., J.H., Lammert, E., Duckers, H.J., and Schulte-Merker, S. (2011) CCBE1 Is Essential for Mammalian Lymphatic Vascular Development and Enhances the Lymphangiogneic Effect of Vascular Endothelial Growth Factor-C In Vivo. Circulation Research109(5): 486-91.

Tao, S., Witte, M., Bryson-Richardson, R.J., Currie, P.D., Hogan, B.M., and Schulte-Merker, S. (2011). Zebrafish prox1b mutants develp a lymphatic vasculature, and prox1b does not specifically mark lymphatic endothelial cells. PLoS One 6(12):e28934.

Vanoevelen, J., Janssens, A., Huitema, L.F.A., Hammonds, C.L., Metz, J.R., Flik, G., Voets, T., and Schulte-Merker, S. (2011). Trpv5/6 is vital for epithelial calcium uptake and bone formation. FASEB Journal 25(9): 3197-207.

Bussmann, J. and Schulte-Merker, S. (2011) Rapid BAC selection for tol2-mediated transgenesis in zebrafish. Development 138, 4327-4332..
http://dev.biologists.org/cgi/reprint/138/19/4327.pdf?ijkey=v3VfTDCtzdzGS42&keytype=finite

Fiedler, J., Jazbutyte, V., Kirchmaier, B.C., Kumar Gupta, S., Lorenzen, J., Hartmann, D., Galuppo, P., Kneitz, S., Pena, J.T.G., Sohn-Lee, C., Loyer, X., Soutschek, J., Brand, T., Tuschl, T., Heineke, J., Martin, U., Schulte-Merker, S., Ertl, G., Engelhardt, S., Bauersachs, J., and Thum, T. (2011). MicroRNA-24 regulates vascularity after myocardial infarction. Circulation 124(6): 720-30.

Cheng, C., Tempel, D., den Dekker, W., Haasdijk, R., Chrifi, I., Bos, F., Wagtmans, K., van de Kamp, E.H., Blonden, L., Biessen, E.A.L., Moll, F., Pasterkamp, G., Serruys, P.W., Schulte-Merker, S., and Duckers, H.J. (2011) Ets2 determines the inflammatory state of endothelial cells in advanced atherosclerotic lesions. Circulation Research 109(4): 382-95.

Knopf, F., Hammond, C., Chekuru, A., Kurth, T., Hans, S., Weber, C.W., Mahatma, G., Fisher, S., Brand, M., Schulte-Merker, S., and Weidinger, G. (2011). Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Developmental Cell 20, 713-724.

Krueger, J., Liu, D., Katja , K., Zimmer, A., Shi,Y., Klein, C., Siekmann, A., Schulte-Merker, S., Cudmore, M., Ahmed, A., and le Noble, A.F. (2011). Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo. Development 138, 2111-2120.

Kärpänen, T and Schulte-Merker, S. (2011). Zebrafish provides a novel model for lymphatic vascular research. Methods in Cell Biolgy, Elsevier (105: 223-238).

Apschner, A., Schulte-Merker, S. and Witten, P.E. (2011). Not all bones are created equal - using zebrafish and other teleost species in osteogenesis research. Methods in Cell Biology, Elsevier (105:239-55).

van Rooijen, E., Santhakumar, K., Logister, I., Voest, E., Schulte-Merker, S., Giles, R., and Schulte-Merker, S. (2011). A Zebrafish Model for VHL and Hypoxia Signaling. Methods in Cell Biology, Elsevier (105: 163-90).

Roukens, M.G., Alloul-Ramdhani, M., Baan, B., Kobayashi, K., Peterson-Maduro, J., van Dam, H., Schulte-Merker, S., and David A. Baker. (2010). Control of endothelial sprouting by a Tel-CtBP complex. Nature Cell Biology 12, 933-43.

Jakobsson, L., Franco, C.A., Bentley, K., Collins, R.T., Ponsioen, B., Aspalter, I.M., Rosewell, I.,Marta Busse, Thurston, G., Medvinsky, A., Schulte-Merker, S., and Holger Gerhardt. (2010). Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nature Cell Biology 12(10), 943-53.

Gjini, E., Hekking, L., Kuchler, A., Saharinen, P., Wienholds, E., Post, J.-A., Alitalo, K., and Schulte-Merker, S. (2010). Zebrafish Tie-2 shares redundant roles with Tie-1 in heart development and regulates vessel integrity. Disease Models & Mechanisms 4, 57-66.

Bussmann, J., Bos, F., Urasaki, A., Kawakami, K., Duckers, H.J., and Schulte-Merker, S. (2010). Arteries provide essential guidance cues for lymphatic endothelial cells in the zebrafish trunk. Development 137, 253-57.

Hermans, K., Claes, F., Wouter Vandevelde; Wei Zheng; Ilse Geudens; Fabrizio Orsenigo; Frederik De Smet; Evisa Gjini; Kristof Anthonis; Bin Ren; Dontscho Kerjaschki; Monica Autiero; Annelii Ny; Michael Simons; Mieke Dewerchin; Stefan Schulte-Merker; Elisabetta Dejana; Kari Alitalo, Carmeliet, P. (2010) Role of synectin in lymphatic development in zebrafish and frogs. Blood 116(17), 3356-66.

Meta-analysis of genome-wide association studies confirms a susceptibility for knee-osteoarthritis on chromosome 7q22. (2010) Evangelou, E., Valdes, A.M., Kerkhof, H.J.M., et al. Annals of the Rheumatic Diseases doi:10.1136/ard.2010.132787.

Geudens, I., Herpers, R., Hermans, K., Segura, I., Ruiz de Almodovar, C., Bussmann, J., De Smet, F., Vandevelde, W., Hogan, B.M., Siekmann, A., Claes, F., Moore, J.C., Pistocchi, A.S., Loges, S., Mazzone,M., Mariggi, G., Bruye`re, F., Cotelli, F., Kerjaschki, D., Noe¨l, A., Foidart, J.-M., Gerhardt, H., Ny, A., Langenberg, T., Lawson, N.D., Duckers, H.J., Schulte-Merker, S., Carmeliet, P., Dewerchin, M. (2010). Role of Dll4/Notch in the Formation and Wiring of the Lymphatic Network in Zebrafish. Arterioscler Thromb Vasc Biol. 30(9), 1695-1702.

Pedrioli, D.M.L., Karpanen, T., Dabouras, V., Jurisic, G., van de Hoek, G., Shin, J.W., Marino, D., Kälin, R.E., Leidel, S., Cinelli, P., Schulte-Merker, S., Brändli, A.W., and Michael Detmar. (2010) miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo. Molecular and Cellular Biology, doi:10.1128/MCB.00185-10 .

Tournoij, E., Weber, G.J., Akkerman, J.N., de Groot, P.G., Zon, L.I., Moll, F., and Schulte-Merker, S. (2010) Mlck1a is expressed in zebrafish thrombocytes and an essential component for thrombus formation. Journal of Thrombosis and Haemostasis 8, 588-595.

van Rooijen, E., Voest, E.E., Logister, I., Bussmann, J., Korving, J., van Eeden, F.J., Giles, R.H., and Schulte-Merker, S. (2010)  von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish. Disease Models & Mechanisms 3, 343-353.

Spoorendonk, K.M., Hammond, C.L., Huitema, L.F.A., Vanoevelen, J., and Schulte-Merker, S. (2010). Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging. Journal of Applied Ichthyology 26, 219-224.

Alders, M., Hogan, B.M., Gjini, E., Salehi, F., Al-Gazali, L., Hennekam, E.A., Holmberg, E.E., Mannens, M.M.A.M., Mulder, M.F., Offerhaus, G.J.A., Prescott, T.E., Schroor, E.J., Verheij, J.B.G.M., Witte, M., Zwijnenburg, P.J., Vikkula, M., Schulte-Merker, S. & Hennekam, R.C. (2009) Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans. Nature Genetics, published online: 22 November 2009 | doi:10.1038/ng.484

Hammond, L.C., and Schulte-Merker, S. (2009) Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signaling. Development 136, 3991-4000.

Hogan, B.M., Herpers, R., Witte, M., Heloterä, H., Alitalo, K., Duckers, H.J., and Schulte-Merker, S. (2009) Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries. Development 136, 4001-4009.

Hogan, B.M., Bos, F., Bussmann, J., Witte, M., Chi, N., Duckers, H.,and Schulte-Merker, S. (2009). Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting. Nature Genetics 41 , 396-398.

van Rooijen, E., Voest, E.E., Logister, I., Korving, J., Schwerte, T., Schulte-Merker, S., Giles, R.H., and van Eeden, F.J. (2009). Zebrafish mutants in the von Hippel-Lindau (VHL) tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia. Blood 113, 6449-6460.

Voss, K., Stahl, S., Hogan, B.M., Reinders, J., Schleider, E., Schulte-Merker, S., and Felbor, U. (2009). Functional analyses of human and zebrafish 18 amino acid in frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 (CCM3) protein. Human Mutation 30(6), 1003-1011.

Brittijn SA, Duivesteijn SJ, Belmamoune M, Bertens LF, Bitter W, de Bruijn JD, Champagne DL, Cuppen E, Flik G, Vandenbroucke-Grauls CM, Janssen RA, de Jong IM, de Kloet ER, Kros A, Meijer AH, Metz JR, van der Sar AM, Schaaf MJ, Schulte-Merker S, Spaink HP, Tak PP, Verbeek FJ, Vervoordeldonk MJ, Vonk FJ, Witte F, Yuan H, Richardson MK. (2009) Zebrafish development and regeneration: new tools for biomedical research. Int J Dev Biology 53 (5-6), 835-50.

Hogan, B.M., and Schulte-Merker, S. (2009). New animal models of lymphangiogenesis. In: Lymphangiogenesis in cancer metastasis. Springer press.

Spoorendonk, K., Peterson-Maduro, J., Renn, J., Trowe, T., Kranenbarg, S., Winkler, C., and Schulte-Merker, S. (2008). Retinoic Acid and Cyp26b1 are Critical Regulators of Osteogenesis in the Axial Skeleton. Development 135, 3765-3774.

Hogan, B.M., Bussmann, J., Wollburg, H. and Schulte-Merker, S. (2008). ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish. Human Molecular Genetics 17, 2424-2432.

Bussmann, J., Lawson, N., Zon, L., Schulte-Merker, S., and Zebrafish Nomenclature Committee. (2008). Zebrafish VEGF Receptors: A Guideline to Nomenclature. PLoS Genetics 4(5):e1000064.

Herpers, R., van de Kamp, E., Duckers, H.J., and Schulte-Merker, S. (2008). Redundant roles for sox7 and sox18 in arteriovenous specification in zebrafish. Circulation Research 102, 12-15.

van Rooijen, E., Giles, R.H., Voest, E.E., van Rooijen, C., Schulte- Merker, S. and van Eeden, F.J. (2008). LRRC50, a conserved ciliary protein implicated in polycystic kidney disease. J. American Society of Nephrology 19: 1128-1138.

Smith, K.A., Chocron, S., von der Hardt, S., de Pater, E., Soufan, A., Bussmann, J., Schulte-Merker, S., Hammerschmidt, M., and Bakkers, J. (2008). Rotation and asymetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Developmental Cell 14, 287-297.

Bussmann, J., Bakkers, J., and Schulte-Merker, S. (2007). Early endocardial morphogenesis requires Scl/Tal1. PLoS Genetics, 3(8): e140.

Küchler, A.M., Gjini, E., Peterson-Maduro, J., Cancilla, B., Wolburg, H., Schulte-Merker, S. (2006). Development of the zebrafish lymphatic system requires Vegfc signaling. Current Biology 16, 1244-1248.

Stéphane Berghmans, Ryan D. Murphey, Erno Wienholds, Donna Neuberg, Jeffrey L. Kutok, Christopher D.M. Fletcher, John P. Morris, Ting-Xi Liu, Stefan Schulte-Merker, John P. Kanki, Ronald Plasterk , Leonard I. Zon, A. Thomas Look. (2005). Malignant peripheral nerve sheath tumors in homozygous p53 mutant zebrafish. PNAS 102, 407-412.

Schulte-Merker, S. (2003). Genetics and Genomics in the Zebrafish - from Gene to Function and Back. Model Organisms in Drug Discovery, p. 185-201.

Martyn, U. and Schulte-Merker, S. (2003). The ventralized ogon mutant phenotype is caused by a defect in the zebrafish sizzled gene. Developmental Biology 260, 58-67.

Habeck, H., Odenthal, J., Walderich, B., Maischein, H.-M., Tübingen 2000 screen consortium, and Schulte-Merker, S. (2002). Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis. Current Biology 12, 1405-1412.

Schulte-Merker, S. (2002). Looking at embryos. Zebrafish - A Practical Approach, p. 39-58.

Wienholds, E., Schulte-Merker, S., Walderich, B., and Plasterk, R. (2002). Target-selected inactivation of the zebrafish rag1 gene. Science 297, 99-102.

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