Publications

Korswagen group

Middelkoop, T., Williams, L., Yang, P.T., Luchtenberg, J., Betist, M., Ji, N., van Oudenaarde, A., Kenyon, C. and Korswagen, H.C. (2011) The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts. Dev. Biol., in press.

Cullen, P., Korswagen, H.C. (2011) Sorting nexins: functional diversification of retromer-dependent trafficking in morphogen secretion and signal transduction. Nature Cell Biol., in press.

Harterink, M., Port, F., Lorenowicz, M., McGough, I., Silhankova, M., Betist, M., van Weering, J., van Heesbeen, R., Middelkoop, T., Basler, K., Cullen, P., Korswagen, H.C. (2011) A SNX3-dependent Retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nature Cell Biol., 13:914-923.

Harterink, M., Kim, D., Middelkoop, T., Doan, T.D., van Oudenaarden, A., Korswagen, H.C. (2011) Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein. Development, 138:2915-2924.

Harterink, M., Korswagen, H.C. (2011) Dissecting the Wnt secretion pathway: key questions on the modification and intracellular trafficking of Wnt proteins. Acta Physiol., in press.

Xiao, Y., Bedet, C., Robert, V.J., Simonet, T., Dunkelbarger, S., Rakotomalala, C., Soete, G., Korswagen, H.C., Strome, S., Palladino, F. (2011) Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys4 methylation in embryos and adult germ cells. Proc. Natl. Acad. Sci. USA 108: 8305-8310.

Korswagen, H.C. (2011) A case of cross-reactivity. Chem. Biol. 18: 409-410.

Silhankova, M., Port, F., Harterink, M., Basler, K. and Korswagen H.C. (2010) Wnt signaling requires MTM-6 and MTM-9 lipid phosphatase function in Wnt producing cells. EMBO J. 15: 4098-105

Isik, M., Korswagen, H.C. and Berezikov, E. (2010) Expression patterns of intronic microRNAs in Caenorhabditis elegans. Silence 1:5.

Ng, S.S., Mahmoudi, T., Danenberg, E., Bejaoui, I., de Lau, W., Korswagen, H.C., Schutte, M. and Clevers, H. (2009) Phosphatidylinositol 3-kinase signaling does not activate the Wnt cascade. J. Biol Chem., 284:35308-13.

Lorenowicz, M.L. and Korswagen, H.C. (2009) Sailing with the Wnt: charting the Wnt processing and secretion route. Exp. Cell Res., 315:2683-2689.

Wassmer, T., Attar, N., Harterink, M., van Weering, J.R.T., Trear, C.J., Oakley, J., Goud, B., Stephens, D.J., Verkade, P., Korswagen, H.C. and Cullen, P. (2009) The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev. Cell, 17:110-122.

Neumann, S., Coudreuse, D.Y., van der Westhuyzen, D.R., Eckhardt, E.R., Korswagen, H.C., Schmitz, G. and Sprong, H. (2009) Mammalian Wnt3a is released on lipoprotein particles. Traffic,10:334-343.

Yang, P.T., Lorenowicz, M., Silhankova, M., Coudreuse, D.Y.M., Betist, M.C. and Korswagen, H.C. (2008) Wnt signaling requires retromer dependent recycling of MIG-14/Wls in Wnt producing cells. Dev. Cell,14:4-6.

Silhankova, M. and Korswagen, H.C. (2007) Migration of neuronal cells along the anterior-posterior body axis of C. elegans: Wnts are in control. Curr. Opin. Genet. Dev., 17:320-325.

Holmes, A., Flett, A., Coudreuse, D., Korswagen, H.C. and Pettitt, J. (2007) C. elegans Disabled is required for cell-type specific endocytosis and is essential in animals lacking the AP-3 adaptor complex. J. Cell Sci. 120:2741-2751.

Oosterveen, T., Coudreuse, D.Y.M., Yang, P.T. Fraser, E., Bergsma, J., Dale, T.C. and Korswagen, H.C. (2007) Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans. Dev. Biol., 308:438-448.

Soete, G., Betist, M.C. and Korswagen, H.C. (2007) Regulation of Caenorhabditis elegans body size and male tail development by the novel gene lon-8. BMC Dev. Biol. 7:20.

Coudreuse, D.Y.M and Korswagen, H.C. (2007) The making of Wnt: new insights into Wnt maturation, sorting and secretion. Development, 134:3-12.

Korswagen, H.C. (2007) Wnt signaling in C. elegans:new insights into the regulation of POP-1/TCF-mediated activation and repression. Adv. Dev. Biol. 17:95-110.

Korswagen, H.C. (2006) Regulation of the Wnt/beta-catenin pathway by redox signaling. Dev. Cell, 10:687-688.

Coudreuse, D.Y.M, Roel, G., Betist, M.C., Destree, O. and Korswagen, H.C. (2006) Wnt gradient formation requires retromer function in Wnt producing cells. Science, 312:921-924.

Essers, M.A., de Vries-Smits, L.M.M., Barker, N., Polderman, P.E., Burgering, B.M.T. and Korswagen, H.C. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science, 308:1181-1184.

Smit, L., Baas, A., Kuipers, J., Korswagen, H., van de Wetering, M. and Clevers, H. (2004) Wnt activates the Tak1/Nlk kinase pathway. J. Biol. Chem., 279:17232-40.

van der Linden, A.M., Moorman, C., Cuppen, E., Korswagen, H.C. and Plasterk, R.H.A. (2003) Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C. Curr. Biol., 13:516-521.

Korswagen, H.C. (2002) Canonical and non-canonical Wnt signalling pathways in C. elegans: variations on a common signalling theme. BioEssays 24:801-810.

Korswagen, H.C.*, Coudreuse, D.Y.M, Betist, M.C., van de Water, S., Zivkovic, D. and Clevers, H.C. (2002) The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes & Dev. 16:1291-1302 (*Corresponding author).

Gleason, J.E., Korswagen, H.C. and Eisenmann, D.E. (2002) Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction. Genes & Dev. 16:1281-1290.

Korswagen, H.C.*, Herman, M.A. and Clevers, H.C. (2000) Distinct beta-catenins mediate adhesion and signalling functions in C. elegans. Nature 406:527-532 (*Corresponding author).

Korswagen, H.C., van der Linden, S.M. and Plasterk, R.H.A. (1998) G protein activation of the Caenorhabditis elegans adenylyl cyclase SGS-1 induces neuronal degeneration. EMBO J. 15:5059-5065.

Korswagen, H.C., Park, J.H., Ohshima, Y. and Plasterk, R.H.A. (1997) An activating mutation in a Caenorhabditis elegans Gs protein induces neural degeneration. Genes & Dev. 11:1493-1503.

Jonkers, J., Korswagen, H.C., Acton, D., Breuer, M. and Berns, A. (1997) Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas. EMBO J. 16:441-450.

Korswagen, H.C., Durbin, R.M., Smits, M.T. and Plasterk, R.H.A.P. (1996) Transposon Tc1-derived sequence-tagged sites in Caenorhabditis elegans as markers for gene mapping. Proc. Natl. Acad. Sci. USA 93:14680-14685.

Mendel, J.E., Korswagen, H.C., Liu, K.S., Hajdu-Cronin, Y.M., Simon, M.I., Plasterk, R.H.A.P. and Sternberg, P.W. (1995) Participation of the protein Go in multiple aspects of behavior in C. elegans. Science 267:1652-1655.

Book chapters
Korswagen, H.C. and Plasterk, R.H.A. (2001) Heterotrimeric G proteins. Encyclopedia of Genetics. Academic Press.

Korswagen, H.C. and Clevers, H.C. (2000) Activation and repression of Wingless/Wnt target genes by the TCF/LEF-1 family of transcription factors. Cold Spring Harbor Symposia on Quantitative Biology, Vol. LXIV:141-147

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