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Korswagen group

Mentink, R.A., Middelkoop, T.C., Rella, L., Ji, N., van Oudenaarden, A., and Korswagen, H.C. (2014) Cell intrinsic modulation of Wnt signaling controls neuroblast migration in C. elegans. Dev Cell 31: 188-201.

de Groot, R.E., Rappel, S.B., Lorenowicz, M.J. and Korswagen H.C. (2014) Protein kinase CK2 is required for Wntless internalization and Wnt secretion. Cell Signal 26: 2601-2605.

Middelkoop, T.C. and Korswagen, H.C. (2014) Development and migration of the C. elegans Q neuroblasts and their descendants. WormBook, ed. The C. elegans Research Community, 10.1895/wormbook.1.173.1.

de Groot, R.E., Ganji, R.S., Bernatik, O., Lloyd-Lewis, B., Seipel, K., Sedova, K., Zdrahal, Z., Dhople, V.M., Date, T., Korswagen, H.C.* and Bryja, V.* (2014) Huwe1-mediated ubiquitylation of Dvl defines a novel negative feedback loop in the Wnt signaling pathway. Science Signal 7: ra26. *Joint senior/corresponding authors.

Bhambhani, C., Ravindranath, A.J., Mentink, R.A., Chang, M.V., Betist, M.C., Yan, Y.X., Koushika, S.P., Korswagen, H.C. and Cadigan, K.M. (2014) Distinct DNA binding sites contribute to the TCF transcriptional switch in C. elegans and Drosophila. PLoS Genet 10: e1004133.

Ji, N., Middelkoop, T.C., Mentink, R.A., Betist, M.C., Tonegawa, S., Mooijman, D., Korswagen, H.C.* and van Oudenaarden, A* (2013) Feedback control of gene expression in the Caenorhabditis elegans Wnt pathway. Cell, 155: 869-880. *Joint senior/corresponding authors.

Sawa, H., and Korswagen, H.C. (2013). Wnt signaling in C. elegans. WormBook, ed. The C. elegans Research Community, doi/10.1895/wormbook.1.7.2.

de Groot, R.E., Farin, H.F., Macurkova, M., van Es, J.H., Clevers, H.C. and Korswagen, H.C. (2013) Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium. PloS One 8: e76971.

Lorenowicz, M.J., Macurkova, M., Harterink, M., Middelkoop, T.C., de Groot, R., Betist, M.C. and Korswagen, H.C. (2013) Inhibition of late endosomal maturation restores Wnt secretion in Caenorhabditis elegans vps-29 retromer mutants. Cell Signal 26: 19-31.

Stout, G.J., Stigter, E.C., Essers, P.B., Mulder, K.W., Kolkman, A., Snijders, D.S., van den Broek,N.J., Betist, M.C., Korswagen, H.C., Macinnes, A.W. and Brenkman, A, (2013) Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism. Mol Syst Biol 9: 679.

Cruciat, C.M., Dolde, C., de Groot, R.E.A., Ohkawara, B., Reinhard, C., Korswagen, H.C. and Niehrs, C. (2013) A rogue kinase no more: RNA helicase DDX3 is a regulatory subunit of casein kinase 1 and transduces Wnt signaling. Science, 339: 1436-1441.

Putker, M., Madl, T., Vos, H., de Ruiter, H., Smolders, A., Visscher, M., van den Berg, M.C.W., Kaplan, M., Braeckman, B.P., Korswagen, H.C., Boelens, R., Vermeulen, M., Burgering, B.M.T. and Dansen T.B. (2013) Redox dependent control of FOXO/DAF-16 by transportin-1. Mol Cell, 49: 730-742.

Tan, R.Z., Ji, N., Mentink, R.A., Korswagen, H.C. and van Oudenaarden, A. (2013) Deconvolving the roles of Wnt ligands and receptors in sensing and amplification. Mol Syst Biol, 9: 631.

Labuschagne, C.F., Stigter, E.C., Hendriks, M.M., Berger, R., Rokach, J., Korswagen, H.C. and Brenkman, A.B. (2012) Quantification of in vivo oxidative damage in Caenorhabditis elegans during aging by endogenous F3-isoprostane measurement. Aging Cell,12: 214-223.

Schneider, J., Skelton, R.L., Von Stetina, S.E., Middelkoop, T.C., van Oudenaarden, A., Korswagen, H.C. and Miller, D.M. (2012) UNC-4 antagonizes Wnt signaling to regulate synaptic choice in the C. elegans motor circuit. Development, 139:2234-2245.

Middelkoop, T., Williams, L., Yang, P.T., Luchtenberg, J., Betist, M., Ji, N., van Oudenaarde, A., Kenyon, C. and Korswagen, H.C. (2011) The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts. Dev Biol, 361:338-348.

Cullen, P., Korswagen, H.C. (2011) Sorting nexins: functional diversification of retromer-dependent trafficking in morphogen secretion and signal transduction. Nature Cell Biol, 14:29-37.

Harterink, M., Port, F., Lorenowicz, M., McGough, I., Silhankova, M., Betist, M., van Weering, J., van Heesbeen, R., Middelkoop, T., Basler, K., Cullen, P., Korswagen, H.C. (2011) A SNX3-dependent Retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nature Cell Biol, 13:914-923.

Harterink, M., Kim, D., Middelkoop, T., Doan, T.D., van Oudenaarden, A., Korswagen, H.C. (2011) Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein. Development, 138:2915-2924.

Harterink, M., Korswagen, H.C. (2011) Dissecting the Wnt secretion pathway: key questions on the modification and intracellular trafficking of Wnt proteins. Acta Physiol, 204:8-16.

Xiao, Y., Bedet, C., Robert, V.J., Simonet, T., Dunkelbarger, S., Rakotomalala, C., Soete, G., Korswagen, H.C., Strome, S., Palladino, F. (2011) Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys4 methylation in embryos and adult germ cells. Proc Natl Acad Sci USA 108: 8305-8310.

Korswagen, H.C. (2011) A case of cross-reactivity. Chem Biol 18: 409-410.

Silhankova, M., Port, F., Harterink, M., Basler, K. and Korswagen H.C. (2010) Wnt signaling requires MTM-6 and MTM-9 lipid phosphatase function in Wnt producing cells. EMBO J 15: 4098-105

Isik, M., Korswagen, H.C. and Berezikov, E. (2010) Expression patterns of intronic microRNAs in Caenorhabditis elegans. Silence 1:5.

Ng, S.S., Mahmoudi, T., Danenberg, E., Bejaoui, I., de Lau, W., Korswagen, H.C., Schutte, M. and Clevers, H. (2009) Phosphatidylinositol 3-kinase signaling does not activate the Wnt cascade. J Biol Chem, 284:35308-13.

Lorenowicz, M.L. and Korswagen, H.C. (2009) Sailing with the Wnt: charting the Wnt processing and secretion route. Exp Cell Res, 315:2683-2689.

Wassmer, T., Attar, N., Harterink, M., van Weering, J.R.T., Trear, C.J., Oakley, J., Goud, B., Stephens, D.J., Verkade, P., Korswagen, H.C. and Cullen, P. (2009) The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell, 17:110-122.

Neumann, S., Coudreuse, D.Y., van der Westhuyzen, D.R., Eckhardt, E.R., Korswagen, H.C., Schmitz, G. and Sprong, H. (2009) Mammalian Wnt3a is released on lipoprotein particles. Traffic,10:334-343.

Yang, P.T., Lorenowicz, M., Silhankova, M., Coudreuse, D.Y.M., Betist, M.C. and Korswagen, H.C. (2008) Wnt signaling requires retromer dependent recycling of MIG-14/Wls in Wnt producing cells. Dev Cell,14:4-6.

Silhankova, M. and Korswagen, H.C. (2007) Migration of neuronal cells along the anterior-posterior body axis of C. elegans: Wnts are in control. Curr Opin Genet Dev, 17:320-325.

Holmes, A., Flett, A., Coudreuse, D., Korswagen, H.C. and Pettitt, J. (2007) C. elegans Disabled is required for cell-type specific endocytosis and is essential in animals lacking the AP-3 adaptor complex. J Cell Sci 120:2741-2751.

Oosterveen, T., Coudreuse, D.Y.M., Yang, P.T. Fraser, E., Bergsma, J., Dale, T.C. and Korswagen, H.C. (2007) Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans. Dev Biol, 308:438-448.

Soete, G., Betist, M.C. and Korswagen, H.C. (2007) Regulation of Caenorhabditis elegans body size and male tail development by the novel gene lon-8. BMC Dev Biol 7:20.

Coudreuse, D.Y.M and Korswagen, H.C. (2007) The making of Wnt: new insights into Wnt maturation, sorting and secretion. Development, 134:3-12.

Korswagen, H.C. (2007) Wnt signaling in C. elegans:new insights into the regulation of POP-1/TCF-mediated activation and repression. Adv Dev Biol17:95-110.

Korswagen, H.C. (2006) Regulation of the Wnt/beta-catenin pathway by redox signaling. Dev Cell, 10:687-688.

Coudreuse, D.Y.M, Roel, G., Betist, M.C., Destree, O. and Korswagen, H.C. (2006) Wnt gradient formation requires retromer function in Wnt producing cells. Science, 312:921-924.

Essers, M.A., de Vries-Smits, L.M.M., Barker, N., Polderman, P.E., Burgering, B.M.T. and Korswagen, H.C. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science, 308:1181-1184.

Smit, L., Baas, A., Kuipers, J., Korswagen, H., van de Wetering, M. and Clevers, H. (2004) Wnt activates the Tak1/Nlk kinase pathway. J Biol Chem, 279:17232-40.

van der Linden, A.M., Moorman, C., Cuppen, E., Korswagen, H.C. and Plasterk, R.H.A. (2003) Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C. Curr Biol, 13:516-521.

Korswagen, H.C. (2002) Canonical and non-canonical Wnt signalling pathways in C. elegans: variations on a common signalling theme. BioEssays 24:801-810.

Korswagen, H.C.*, Coudreuse, D.Y.M, Betist, M.C., van de Water, S., Zivkovic, D. and Clevers, H.C. (2002) The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes Dev 16:1291-1302 (*Corresponding author).

Gleason, J.E., Korswagen, H.C. and Eisenmann, D.E. (2002) Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction. Genes Dev 16:1281-1290.

Korswagen, H.C.*, Herman, M.A. and Clevers, H.C. (2000) Distinct beta-catenins mediate adhesion and signalling functions in C. elegans. Nature 406:527-532 (*Corresponding author).

Korswagen, H.C., van der Linden, S.M. and Plasterk, R.H.A. (1998) G protein activation of the Caenorhabditis elegans adenylyl cyclase SGS-1 induces neuronal degeneration. EMBO J 15:5059-5065.

Korswagen, H.C., Park, J.H., Ohshima, Y. and Plasterk, R.H.A. (1997) An activating mutation in a Caenorhabditis elegans Gs protein induces neural degeneration. Genes Dev 11:1493-1503.

Jonkers, J., Korswagen, H.C., Acton, D., Breuer, M. and Berns, A. (1997) Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas. EMBO J 16:441-450.

Korswagen, H.C., Durbin, R.M., Smits, M.T. and Plasterk, R.H.A.P. (1996) Transposon Tc1-derived sequence-tagged sites in Caenorhabditis elegans as markers for gene mapping. Proc Natl Acad Sci USA 93:14680-14685.

Mendel, J.E., Korswagen, H.C., Liu, K.S., Hajdu-Cronin, Y.M., Simon, M.I., Plasterk, R.H.A.P. and Sternberg, P.W. (1995) Participation of the protein Go in multiple aspects of behavior in C. elegans. Science 267:1652-1655.

Book chapters
Korswagen, H.C. and Plasterk, R.H.A. (2001) Heterotrimeric G proteins. Encyclopedia of Genetics. Academic Press.

Korswagen, H.C. and Clevers, H.C. (2000) Activation and repression of Wingless/Wnt target genes by the TCF/LEF-1 family of transcription factors. Cold Spring Harbor Symposia on Quantitative Biology, Vol. LXIV:141-147

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