During the development of multi-cellular organisms, cells communicate with each other to orchestrate the complex mechanisms that lead to the formation of tissues and organs. Of particular importance is signaling through members of the highly conserved family of Wnt proteins, which are secreted, lipid modified signaling proteins that can act as short-range signaling molecules, but also as long-range morphogens that form concentration gradients to provide positional information to cells in developing tissues. A major focus of our current research is to determine how the lipid-modified Wnt protein is secreted and released from Wnt producing cells and how this process impacts on its ability to spread in the tissue. We address this question using genetic and cell biological approaches in the nematode C. elegans.
About the research
de Groot, R.E., Ganji, R.S., Bernatik, O., Lloyd-Lewis, B., Seipel, K., Sedova, K., Zdrahal, Z., Dhople, V.M., Date, T., Korswagen, H.C.* and Bryja, V.* (2014) Huwe1-mediated ubiquitylation of Dvl defines a novel negative feedback loop in the Wnt signaling pathway. Science Signaling 7: ra26 . *Joint senior/corresponding authors. See also: Science Signaling Podcast
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