Publications

Heimberg group

Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen O, Serup P, Heimberg H, and Mansouri A. The misexpression of Pax4 in the mouse pancreas converts progenitor cells into alpha- and subsequently beta-cells. Cell. 2009 Aug 7;138(3):449-462. PMID: 19665969. IF: 29.2 + Preview by Z. Liu and J. Habener “Alpha cells beget beta cells”

Baeyens L, Bonné S, Bos T, Peleman C, Lahoutte T, German M, Heimberg H, Bouwens L. Notch signaling as gatekeeper of rat acinar-to-beta cell conversion in vitro. Gasteroenterology. 2009 (in press) IF: 11.7

Klein T, Heremans Y, Heimberg H, Pipeleers D, Madsen OD, Serup P, Heller RS. Investigation and characterization of the duct cell enriching process during serum free suspension- and monolayer culture using the human exocrine pancreas fraction. Pancreas. 2009 Jan;38(1):36-48. IF: 2.3

Heimberg H. Boosting Beta Cell Numbers. N Engl J Med. 2008 Dec 18;359(25):2723-4. IF: 52.6
Scharfmann R, Xiao X, Heimberg H, Mallet J, Ravassard P. Beta cells within single human islets originate from multiple progenitors. PlosONE. 2008;3(10):e3559. Epub 2008 Oct 29.

Wang Q, Heimberg H, Pipeleers D, Ling Z. Glibenclamide Activates Translation in Rat Pancreatic Beta-cells through Calcium-dependent mTOR, PKA and MEK Signaling Pathways. Diabetologia. 2008 Jul;51(7):1202-12. IF: 5.2

Vandenbroucke RE, De Geest BG, Bonné S, Vanhaecke T, Heimberg H, Wagner E, De Smedt SC, Demeester J, Sanders NN. Prolonged gene silencing in hepatoma cells and primary hepatocytes after siRNA delivery with biodegradable poly(beta-amino esters). J. Gene Medicine. 2008 Jul;10(7):783-94. IF: 3.9

Cai Y, Wang Q, Ling Z, Pipeleers D, McDermott P, Pende M, Heimberg H, Van de Casteele M. Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Biochem Pharmacol. 2008 May 15;75(10):1981-93. IF: 3.6

Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van de Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Scharfmann R, Gradwohl G, Heimberg H. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell. 2008 Jan 25;132(2):197-207. (Featured Article). PMID: 18243096. IF: 29.2 + Leading Edge Preview by Y. Dor and D. Melton “Facultative endocrine progenitor cell in the adult pancreas”. Comments were in Nature, Science and Scientific American, Research Highlight in Nature Reviews Molecular Cell Biology. F1000 Factor 6.0 (Must Read) by K. Zaret. On the day of publication this paper reached the number 1 position, for 4 weeks, of CELL’s Top20 list , based on the number of downloads. One of the 2 “Key Papers” in Diabetes Research in 2008 (Nature Medicine, 2008, 14(12):1302).

Mfopou JK, De Groote V, Xu X, Heimberg H, Bouwens L. Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development. Stem Cells. 2007 May;25(5):1156-65. IF: 7.9

Hinke SA, Martens GA, Cai Y, Finsi J, Heimberg H, Pipeleers D, Van de Casteele M. Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer. Br J Pharmacol. 2007 Apr;150(8):1031-43. IF: 5.4

Grapin-Botton A, Heimberg H, Lemaigre F. The genetic programme of pancreatic beta-cells: basic science for the development of beta-cell therapy. Workshop on programming pancreatic beta-cells. EMBO Rep. 2007 Apr;8(4):322-6. PMCID: PMC1852767. IF: 8.2

Cai Y, Martens GA, Hinke SA, Heimberg H, Pipeleers D, Van de Casteele M. Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation. Free Radic Biol Med. 2007 Jan 1;42(1):64-78. IF: 5.0

Baeyens L, Bonné S, German MS, Ravassard P, Heimberg H, Bouwens L. Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway. Cell Death Differ. 2006 Nov;13(11):1892-9. IF: 7.9

Rooman I, De Medts N, Baeyens L, Lardon J, De Breuck S, Heimberg H, Bouwens L. Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas. Am J Pathol. 2006 Oct;169(4):1206-14. IF: 5.8

Harb G, Heremans Y, Heimberg H, Korbutt GS. Ectopic expression of neurogenin 3 in neonatal pig pancreatic precursor cells induces (trans)differentiation to functional alpha cells. Diabetologia. 2006 Aug;49(8):1855-63. IF: 5.3

Mellitzer G, Bonné S, Luco RF, Van De Casteele M, Lenne-Samuel N, Collombat P, Mansouri A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G, Heimberg H. IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J. 2006 Mar 22;25(6):1344-52. PMCID: PMC1422151. IF: 10.6

Huypens P, Moens K, Heimberg H, Ling Z, Pipeleers D, Van de Casteele M. Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells. Life Sci. 2005 Jul 29;77(11):1273-82. IF: 2.5

Rescan C, Le Bras S, Lefebvre VH, Frandsen U, Klein T, Foschi M, Pipeleers DG, Scharfmann R, Madsen OD, Heimberg H. EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade. Lab Invest. 2005 Jan;85(1):65-74. IF: 3.7

Kefas BA, Cai Y, Kerckhofs K, Ling Z, Martens G, Heimberg H, Pipeleers D, Van de Casteele M. Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis. Biochem Pharmacol. 2004 Aug 1;68(3):409-16. IF: 3.4

Heimberg H. [Reprogramming of adult human pancreatic duct cells as functional beta cells] Verh K Acad Geneeskd Belg. 2004;66(3):183-96.

Van de Casteele M, Kefas BA, Cai Y, Heimberg H, Scott DK, Henquin JC, Pipeleers D, Jonas JC. Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc Biochem Biophys Res Commun. 2003 Dec 26;312(4):937-44. IF: 2.8

Ling Z, Van de Casteele M, Dong J, Heimberg H, Haefliger JA, Waeber G, Schuit F, Pipeleers D. Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling. Diabetes. 2003 Oct;52(10):2497-502. IF: 8.3

Klein T, Ling Z, Heimberg H, Madsen OD, Heller RS, Serup P. Nestin is expressed in vascular endothelial cells in the adult human pancreas. J Histochem Cytochem. 2003 Jun;51(6):697-706. IF: 2.4

Kefas BA, Cai Y, Ling Z, Heimberg H, Hue L, Pipeleers D, Van de Casteele M. AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. J Mol Endocrinol. 2003 Apr;30(2):151-61. IF: 3.7

Kefas BA, Heimberg H, Vaulont S, Meisse D, Hue L, Pipeleers D, Van de Casteele M. AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase. Diabetologia. 2003 Feb;46(2):250-4. IF: 5.7

Heller RS, Klein T, Ling Z, Heimberg H, Katoh M, Madsen OD, Serup P. Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas. Gene Expr. 2003;11(3-4):141-7. IF: 2.7

Heremans Y, Van De Casteele M, in't Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D, Heimberg H. Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol. 2002 Oct 28;159(2):303-12. IF: 12.5

Van de Casteele M, Kefas BA, Ling Z, Heimberg H, Pipeleers DG. Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis. Endocrinology. 2002 Jan;143(1):320-6. IF: 5.1

Van De Casteele M, Heimberg H, Ling Z, Pipeleers D. Cytokine-mediated apoptosis in rat beta-cells is preceded by downregulation of Bcl-2 and Bax-omega expression. Diabetes. 2001 50, 82. IF: 7.7

Cardozo AK, Heimberg H, Heremans Y, Leeman R, Kutlu B, Kruhøffer M, Ørntoft T, Eizirik DL. A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells. J Biol Chem. 2001 Dec 28;276(52):48879-86. IF: 7.3

Heimberg H, Heremans Y, Jobin C, Leemans R, Cardozo AK, Darville M, Eizirik DL. Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis. Diabetes. 2001 Oct;50(10):2219-24. IF: 7.7

Schuit FC, Huypens P, Heimberg H, Pipeleers DG. Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes. 2001 Jan;50(1):1-11. IF: 7.7

Rooman I, Heremans Y, Heimberg H, Bouwens L. Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro. Diabetologia. 2000 Jul;43(7):907-14. IF: 5.7

Heimberg H, Bouwens L, Heremans Y, Van De Casteele M, Lefebvre V, Pipeleers D. Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1. Diabetes. 2000 Apr;49(4):571-9. IF: 7.7

Rochlitz H, Voigt A, Lankat-Buttgereit B, Göke B, Heimberg H, Nauck MA, Schiemann U, Schatz H, Pfeiffer AF. Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells. Diabetologia. 2000 Apr;43(4):465-73. IF: 5.7

Schuit F, Moens K, Heimberg H, Pipeleers D. Cellular origin of hexokinase in pancreatic islets. J Biol Chem. 1999 Nov 12;274(46):32803-9. IF: 7.7

Heimberg H. Transcription factors in developing endocrine pancreas. Ann Endocrinol (Paris). 1999 Sep;60(3):249-50. IF: 0.4

Hresko RC, Heimberg H, Chi MM, Mueckler M. Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP. J Biol Chem. 1998 Aug 7;273(32):20658-68. IF: 7.2

Yang CZ, Heimberg H, D'Souza-Schorey C, Mueckler MM, Stahl PD. Subcellular distribution and differential expression of endogenous ADP-ribosylation factor 6 in mammalian cells. J Biol Chem. 1998 Feb 13;273(7):4006-11. IF: 7.2

Ling Z, Heimberg H, Foriers A, Schuit F, Pipeleers D. Differential expression of rat insulin I and II messenger ribonucleic acid after prolonged exposure of islet beta-cells to elevated glucose levels. Endocrinology. 1998 Feb;139(2):491-5. IF: 4.6

Ferber S, Heimberg H, Brownlee M, Colton C. Surrogate beta cells. Diabetologia. 1997 Oct;40 Suppl 3:B39-43. IF: 5.7

Schuit FC, De Vos A, Moens K, Quartier E, Heimberg H. Glucose-induced B-cell recruitment and the expression of hexokinase isoenzymes. Adv Exp Med Biol. 1997;426:259-66. IF: 0.4

Heimberg H, De Vos A, Moens K, Quartier E, Bouwens L, Pipeleers D, Van Schaftingen E, Madsen O, Schuit F. The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells. Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7036-41. IF: 9.8

Moens K, Heimberg H, Flamez D, Huypens P, Quartier E, Ling Z, Pipeleers D, Gremlich S, Thorens B, Schuit F. Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells. Diabetes. 1996 Feb;45(2):257-61. IF: 8.5

De Vos A, Heimberg H, Quartier E, Huypens P, Bouwens L, Pipeleers D, Schuit F. Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. J Clin Invest. 1995 Nov;96(5):2489-95. IF: 9.3

Crabeel M, de Rijcke M, Seneca S, Heimberg H, Pfeiffer I, Matisova A. Further definition of the sequence and position requirements of the arginine control element that mediates repression and induction by arginine in Saccharomyces cerevisiae. Yeast. 1995 Nov;11(14):1367-80. IF: 2.2

Van der Auwera B, Van Waeyenberge C, Schuit F, Heimberg H, Vandewalle C, Gorus F, Flament J. DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry. Diabetes. 1995 May;44(5):527-30. IF: 8.5

Heimberg H, De Vos A, Pipeleers D, Thorens B, Schuit F. Differences in glucose transporter gene expression between rat pancreatic alpha- and beta-cells are correlated to differences in glucose transport but not in glucose utilization. J Biol Chem. 1995 Apr 14;270(15):8971-5. IF: 7.2

Bouwens L, Braet F, Heimberg H. Identification of rat pancreatic duct cells by their expression of cytokeratins 7, 19, and 20 in vivo and after isolation and culture. J Histochem Cytochem. 1995 Mar;43(3):245-53. IF: 2.5

Heimberg H, De Vos A, Vandercammen A, Van Schaftingen E, Pipeleers D, Schuit F. Heterogeneity in glucose sensitivity among pancreatic beta-cells is correlated to differences in glucose phosphorylation rather than glucose transport. EMBO J. 1993 Jul;12(7):2873-9. IF: 13.2

van der Auwera BJ, Heimberg H, Schrevens AF, van Waeyenberge C, Flament J, Schuit FC. 5' insulin gene polymorphism confers risk to IDDM independently of HLA class II susceptibility. Diabetes. 1993 Jun;42(6):851-4. IF: 8.5

Heimberg H, Nagy ZP, Somers G, De Leeuw I, Schuit FC. Complementation of HLA-DQA and -DQB genes confers susceptibility and protection to insulin-dependent diabetes mellitus. Hum Immunol. 1992 Jan;33(1):10-7. IF: 2.2

Heimberg H, Boyen A, Crabeel M, Glansdorff N. Escherichia coli and Saccharomyces cerevisiae acetylornithine aminotransferase: evolutionary relationship with ornithine aminotransferase. Gene. 1990 May 31;90(1):69-78. IF: 2.0

Chapters in books
Stangé G, Van De Casteele M, Heimberg H. Purification of rat pancreatic beta cells by fluorescence-activated cell sorting. In “Diabetes Mellitus: Methods and Protocols”, Humana Press, edited by Ozcan S. Methods Mol Med. 2003;83:15-22.

Xu X, D’Hoker J, De Leu N, Xiao X, Heremans Y, Van De Casteele M, and Heimberg H. Islet regeneration. In “Stem cell Therapy for diabetes”, Humana Press, edited by Efrat S. 2009 (in press).

About the group leader
About the research