Publications

Guardavaccaro group

E. Dehan, F. Bassermann, D. Guardavaccaro, G. Vasiliver-Shamis, M. Cohen, K.N. Lowes, M. Dustin, D.C.S. Huang, J.Taunton, and M. Pagano.
βTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.
Mol Cell 33(1):109-16, 2009.

D. Frescas, D. Guardavaccaro, S.M. Kuchay, H. Kato, A. Poleshko, V. Basrur, K.S. Elenitoba-Johnson, R.A. Katz, and M. Pagano.
KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state.
Cell Cycle, 24;7(22), 2008.

F. Bassermann, D. Frescas, D. Guardavaccaro, L. Busino, A. Peschiaroli, and M. Pagano.
The Cdc14B-Cdh1-Plk1 axis in the control of the G2 DNA damage response checkpoint.
Cell, 134(2):256-67, 2008.
Comment in: Cell 134(2):210-2, 2008.

X. Zhao, J. Ik-Tsen Heng, D. Guardavaccaro, R. Jiang, M. Pagano, F. Guillemot, A. Iavarone, and A. Lasorella.
The HECT-domain ubiquitin ligase Ureb1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
Nat Cell Biol, 10(6):643-53, 2008

D. Michaelson, W. Abidi, D. Guardavaccaro, M. Zhou, I. Ahearn, M. Pagano and M.R. Philips.
Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division.
J Cell Biol, 181(3), 485-496, 2008.

D. Guardavaccaro, D. Frescas, N.V. Dorrello, A. Peschiaroli, A.S. Multani, T.Cardozo, A. Lasorella, A. Iavarone, S. Chang, E. Hernando, and M. Pagano.
Control of chromosome stability by the βTRCP-REST-MAD2 axis.
Nature, 452(7185) 365-70, 2008.
Comment in: Cancer Cell 13(5):381-3, 2008
Comment in: Nature Reviews Cancer 8(5), 327, 2008

D. Frescas, D. Guardavaccaro, F. Bassermann, R. Koyama-Nasu and M. Pagano.
The histone demethylase JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes.
Nature 450(7167) 309-13, 2007.

V. Amador, S. Ge, P.G. Santamaria, D. Guardavaccaro and M. Pagano.
APC/CCdc20 controls the ubiquitin-mediated degradation of p21 in prometaphase
Mol Cell 27(3):462-73, 2007.

N. Fielenbach, D. Guardavaccaro, K. Neubert, T. Chan, D. Li, Q. Feng, H. Hutter, M. Pagano and A. Antebi.
DRE-1, an evolutionarily conserved F-box protein that regulates C. elegans developmental age.
Dev Cell 12(3):443-55, 2007.

N.V. Dorrello, A. Peschiaroli, D. Guardavaccaro, N.H. Colburn, N.E. Sherman and M. Pagano.
SCFβTrcp- and S6K1-mediated degradation of PDCD4 promotes protein translation and cell growth.
Science 314(5798):467-71, 2006.
Comment in: Science 314(5798):428-9, 2006

A. Peschiaroli, N. V. Dorrello, D. Guardavaccaro, M. Venere, T. Halazonetis, N.E. Sherman and M. Pagano.
SCFβTrcp-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.
Mol Cell 23(3):319-29, 2006.
Comment in: Curr Biol 16(21):R932-4, 2006

A. Lasorella, J. Stegmüller, D. Guardavaccaro, G. Liu, M.S. Carro, G. Rothschild, L. de la Torre-Ubieta, M. Pagano, A. Bonni and A. Iavarone.
Degradation of Id2 by the Anaphase Promoting Complex couples control of cell cycle exit and axonal growth.
Nature 442(7101):471-4, 2006.
Comment in: Nature 442(7101):365-6, 2006

P. Ji, L. Goldin, H. Ren, D. Sun, D. Guardavaccaro, M. Pagano and L. Zhu.
Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27.
J Biol Chem 281(33):24058-69, 2006.

D. Guardavaccaro and M. Pagano.
Stabilizers and destabilizers controlling cell cycle oscillators.
Mol Cell 22:1-455 2006.

Y. Kudo*, D. Guardavaccaro*, P.Gonzalez Santamaria, R. Koyama-Nasu, E. Latres, R. Bronson, L. Yamasaki and M. Pagano.
Role of F-box protein βTrcp1 in mammary gland development and tumorigenesis.
Mol Cell Biol 24: 8184-8194, 2004.
*These two authors contributed equally to this work

D. Guardavaccaro and M. Pagano.
Oncogenic aberrations of cullin-dependent ubiquitin ligases.
Oncogene 23(11):2037-49, 2004.

T. Bashir, N.V. Dorrello, V. Amador, D. Guardavaccaro and M. Pagano.
Control of the SCFSkp2-Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase.
Nature 428(6979):190-3, 2004.
Comment in: Nature Reviews Molecular Cell Biology 5, 339 2004

L. Busino, M. Donzelli, M. Chiesa, D. Guardavaccaro, D. Ganoth, N.V. Dorrello, A. Hershko, M. Pagano and G. Draetta.
Ubiquitin-mediated degradation of Cdc25A by βTrCP during S phase and in response to DNA damage.
Nature 426(6962):87-9, 2003.

D. Guardavaccaro, Y. Kudo, J. Boulaire, M. Barchi, L. Busino, M. Donzelli, Yamasaki L. and M. Pagano.
Control of meiotic and mitotic progression by the F-box protein βTrcp1 in vivo.
Dev Cell 4: 799–812, 2003.
Comment in: Mol Cell 11(6):1420-1, 2003

G. Corrente, D. Guardavaccaro, F. Tirone.
PC3 potentiates NGF-induced differentiation and protects neurons from apoptosis.
Neuroreport 13(4):417-22, 2002.

D. Guardavaccaro, G. Corrente, F. Covone, L. Micheli, I. D'Agnano, G. Starace, M. Caruso and F. Tirone.
Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription.
Mol Cell Biol 20: 1797-815, 2000.

C. Cenciarelli, D. S. Chiaur, D. Guardavaccaro, W. Parks, M. Vidal, and M. Pagano. Identification of a family of human F-box proteins.
Curr Biol 9: 1177-1179, 1999.

P. Buanne, B. Incerti, D. Guardavaccaro, V. Avvantaggiato, A. Simeone and F. Tirone.
Cloning of the human Interferon-Related Developmental Regulator (IFRD1) gene coding for the PC4 protein, member of a novel family of developmentally regulated genes.
Genomics 51: 233-42, 1998.

A. Montagnoli, D. Guardavaccaro, G. Starace and F. Tirone: Overexpression of the PC3 immediate early gene is associated to inhibition of cell proliferation.
Cell Growth Differ 7: 1327-1336, 1996.

D. Guardavaccaro, M.T. Ciotti, B.W. Schafer, A. Montagnoli and F. Tirone.
Inhibition of differentiation in myoblasts deprived of the interferon-related protein PC4.
Cell Growth Differ 6: 159-169, 1995.

D. Guardavaccaro, A. Montagnoli, M.T. Ciotti, L. Lotti, C. Di Lazzaro, M.R. Torrisi, A. Gatti and F. Tirone.
Nerve Growth Factor regulates the subcellular localization of the NGF inducible protein PC4 in PC12 cells.
J Neurosci Res 37: 660-674, 1994.

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