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Guardavaccaro group

Nodal Signaling Range Is Regulated by Proprotein Convertase-Mediated Maturation.
Tessadori F, Noël ES, Rens EG, Magliozzi R, Evers-van Gogh IJ, Guardavaccaro D, Merks RM, Bakkers J.
Dev Cell. 2015 Feb 11. pii: S1534-5807(14)00835-1. doi: 10.1016/j.devcel.2014.12.014

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.
Low TY, Peng M, Magliozzi R, Mohammed S, Guardavaccaro D, Heck AJ.
Science Signaling 2014 Dec 16;7(356):rs8. doi: 10.1126/scisignal.2005882

USP17- and SCFβTrCP-regulated degradation of DEC1 controls the DNA  damage response.
Kim J, D'Annibale S, Magliozzi R, Low TY, Jansen P, Shaltiel IA, Mohammed S, Heck AJ, Medema RH, Guardavaccaro D.
Mol Cell Biol. 2014 Sep 8. pii: MCB.00530-14

βTrCP- and CK1-mediated degradation of Tiam1 controls the duration of mTOR-S6K signaling.
Magliozzi R, Kim J, Low TY, Heck AJ, Guardavaccaro D.
J Biol Chem. 2014 Aug 14. pii: jbc.M114.575571

Proteasome-dependent degradation of Transcription Factor AP4 (TFAP4) controls mitotic division.
D'Annibale S, Kim J, Magliozzi R, Low TY, Mohammed S, Heck AJ, Guardavaccaro D.
J Biol Chem. 2014 Mar 14;289(11):7730-7

Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2.
Magliozzi R, Low TY, Weijts BGMW, Cheng T, Spanjaard E, Mohammed S, van Veen A, Ovaa H, de Rooij J, Zwartkruis FJT, Bos JL, de Bruin A, Heck AJ, Guardavaccaro D.
Dev Cell. 2013 Dec 9;27(5):574-85.

Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response.
Karim R, Tummers B, Meyers C, Biryukov JL, Alam S, Backendorf C, Jha V, Offringa R, van Ommen GJ, Melief CJ, Guardavaccaro D, Boer JM, van der Burg SH.
PLoS Pathog. 2013 May;9(5):e1003384

Unraveling the ubiquitin-regulated signaling networks by mass spectrometry-based proteomics.
Low TY, Magliozzi R, Guardavaccaro D, Heck AJ.
Proteomics. 2013 Feb;13(3-4):526-37.

Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.
Kruiswijk F, Yuniati L, Magliozzi R, Low TW, Lim R, Bolder R, Mohammed S, Proud CG, Heck AJ, Pagano M, and Guardavaccaro D.
Science Signaling. 2012 Jun 5;5(227):ra40

APC/C (Cdh1) controls the proteasome-mediated degradation of E2F3 during cell cycle exit.
Ping Z, Lim R, Bashir T, Pagano M, Guardavaccaro D.
Cell Cycle. 2012 May 15;11(10).

Asb11 is a regulator of embryonic and adult regenerative myogenesis.
Tee JM, Sartori da Silva M, Rygiel A, Muncan V, Bink R, van den Brink G, van Tijn P, Zivkovic D, Kodach L, Guardavaccaro D, Diks S, Peppelenbosch M.
Stem Cells Dev. 2012 Apr 18.

Wnt/β-catenin and MAPK signaling: allies and enemies in different battlefields.
Guardavaccaro D, Clevers H.
Science Signaling. 2012 Apr 10;5(219):pe15.

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H.
Nature. 2011 Jul 4;476(7360):293-7.

Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo.
Sartori da Silva MA, Tee JM, Paridaen J, Brouwers A, Runtuwene V, Zivkovic D, Diks SH, Guardavaccaro D, Peppelenbosch MP.
PLoS One. 2010 Nov 19;5(11):e14023.

βTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.
Dehan E, Bassermann F, Guardavaccaro D, Vasiliver-Shamis G, Cohen M, Lowes KN, Dustin M, Huang DC, Taunton J, Pagano M.
Mol Cell. 2009 Jan 16;33(1):109-16.

KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state.
Frescas D, Guardavaccaro D, Kuchay SM, Kato H, Poleshko A, Basrur V, Elenitoba-Johnson KS, Katz RA, Pagano M.
Cell Cycle
. 2008 Nov 15;7(22):3539-47.

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.
Bassermann F, Frescas D, Guardavaccaro D, Busino L, Peschiaroli A, Pagano M.
Cell. 2008 Jul 25;134(2):256-67.

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
Zhao X, Heng JI, Guardavaccaro D, Jiang R, Pagano M, Guillemot F, Iavarone A, Lasorella A.
Nat Cell Biol. 2008 Jun;10(6):643-53.

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division.
Michaelson D, Abidi W, Guardavaccaro D, Zhou M, Ahearn I, Pagano M, Philips MR.
J Cell Biol. 2008 May 5;181(3):485-96.

Control of chromosome stability by the βTrCP-REST-Mad2 axis.
Guardavaccaro D, Frescas D, Dorrello NV, Peschiaroli A, Multani AS, Cardozo T, Lasorella A, Iavarone A, Chang S, Hernando E, Pagano M.
Nature. 2008 Mar 20;452(7185):365-9.

JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes.
Frescas D, Guardavaccaro D, Bassermann F, Koyama-Nasu R, Pagano M.
Nature. 2007 Nov 8;450(7167):309-13.

APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase.
Amador V, Ge S, Santamaría PG, Guardavaccaro D, Pagano M.
Mol Cell. 2007 Aug 3;27(3):462-73.

DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age.
Fielenbach N, Guardavaccaro D, Neubert K, Chan T, Li D, Feng Q, Hutter H, Pagano M, Antebi A.
Dev Cell. 2007 Mar;12(3):443-55.

S6K1- and βTrCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
Dorrello NV, Peschiaroli A, Guardavaccaro D, Colburn NH, Sherman NE, Pagano M.
Science. 2006 Oct 20;314(5798):467-71.

SCFβTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.
Peschiaroli A, Dorrello NV, Guardavaccaro D, Venere M, Halazonetis T, Sherman NE, Pagano M.
Mol Cell. 2006 Aug 4;23(3):319-29.

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.
Lasorella A, Stegmüller J, Guardavaccaro D, Liu G, Carro MS, Rothschild G, de la Torre-Ubieta L, Pagano M, Bonni A, Iavarone A.
Nature. 2006 Jul 27;442(7101):471-4.

Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1.
Ji P, Goldin L, Ren H, Sun D, Guardavaccaro D, Pagano M, Zhu L.
J Biol Chem. 2006 Aug 18;281(33):24058-69.

Stabilizers and destabilizers controlling cell cycle oscillators.
Guardavaccaro D, Pagano M.
Mol Cell. 2006 Apr 7;22(1):1-4.

Role of F-box protein βTrCP1 in mammary gland development and tumorigenesis.
Kudo Y, Guardavaccaro D, Santamaria PG, Koyama-Nasu R, Latres E, Bronson R, Yamasaki L, Pagano M.
Mol Cell Biol. 2004 Sep;24(18):8184-94.

Oncogenic aberrations of cullin-dependent ubiquitin ligases.
Guardavaccaro D, Pagano M.
Oncogene. 2004 Mar 15;23(11):2037-49.

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.
Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M.
Nature. 2004 Mar 11;428(6979):190-3.

Degradation of Cdc25A by βTrCP during S phase and in response to DNA damage.
Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF.
Nature. 2003 Nov 6;426(6962):87-91.

Control of meiotic and mitotic progression by the F box protein βTrCP1 in vivo.
Guardavaccaro D, Kudo Y, Boulaire J, Barchi M, Busino L, Donzelli M, Margottin-Goguet F, Jackson PK, Yamasaki L, Pagano M.
Dev Cell. 2003 Jun;4(6):799-812.

PC3 potentiates NGF-induced differentiation and protects neurons from apoptosis.
Corrente G, Guardavaccaro D, Tirone F.
. 2002 Mar 25;13(4):417-22.

Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription.
Guardavaccaro D, Corrente G, Covone F, Micheli L, D'Agnano I, Starace G, Caruso M, Tirone F.
Mol Cell Biol. 2000 Mar;20(5):1797-815.

Identification of a family of human F-box proteins.
Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M.
Curr Biol. 1999 Oct 21;9(20):1177-9.

Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes.
Buanne P, Incerti B, Guardavaccaro D, Avvantaggiato V, Simeone A, Tirone F.
Genomics. 1998 Jul 15;51(2):233-42.

Overexpression of the nerve growth factor-inducible PC3 immediate early gene is associated with growth inhibition.
Montagnoli A, Guardavaccaro D, Starace G, Tirone F.
Cell Growth Differ. 1996 Oct;7(10):1327-36.

Inhibition of differentiation in myoblasts deprived of the interferon-related protein PC4.
Guardavaccaro D, Ciotti MT, Schäfer BW, Montagnoli A, Tirone F.
Cell Growth Differ. 1995 Feb;6(2):159-69.

Nerve growth factor regulates the subcellular localization of the nerve growth factor-inducible protein PC4 in PC12 cells.
Guardavaccaro D, Montagnoli A, Ciotti MT, Gatti A, Lotti L, Di Lazzaro C, Torrisi MR, Tirone F.
J Neurosci Res. 1994 Apr 1;37(5):660-74.