Guardavaccaro group

Ubiquitin ligases and cancer

The ubiquitin-proteasome system controls molecular networks that underlie fundamental cellular functions such as DNA replication, DNA repair, transcription, protein synthesis, cell differentiation and apoptosis. A large body of experimental and clinical data reveals that aberrations in the ubiquitin-dependent protein degradation are intimately linked with cancer pathogenesis. The main objective of our research is the elucidation of the molecular mechanisms by which deregulated function of Cullin-RING ubiquitin ligases contribute to oncogenesis. To this end we use an interdisciplinary approach that includes biochemical and cellular biological methods as well as mouse genetics.

Group

About the research

Key publications

Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.
Kruiswijk F, Yuniati L, Magliozzi R, Low TW, Lim R, Bolder R, Mohammed S, Proud CG, Heck AJR, Pagano M, and Guardavaccaro D.
Science Signaling. 2012 Jun 5;5(227):ra40.
See also: Perspective

βTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.
Dehan E, Bassermann F, Guardavaccaro D, Vasiliver-Shamis G, Cohen M, Lowes KN, Dustin M, Huang DC, Taunton J, Pagano M.
Mol Cell. 2009 Jan 16;33(1):109-16.

Control of chromosome stability by the βTrCP-REST-Mad2 axis.
Guardavaccaro D, Frescas D, Dorrello NV, Peschiaroli A, Multani AS, Cardozo T, Lasorella A, Iavarone A, Chang S, Hernando E, Pagano M.
Nature. 2008 Mar 20;452(7185):365-9.

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.
Lasorella A, Stegmüller J, Guardavaccaro D, Liu G, Carro MS, Rothschild G, de la Torre-Ubieta L, Pagano M, Bonni A, Iavarone A.
Nature. 2006 Jul 27;442(7101):471-4.

Control of meiotic and mitotic progression by the F-box protein βTrCP1 in vivo.
Guardavaccaro D, Kudo Y, Boulaire J, Barchi M, Busino L, Donzelli M, Margottin-Goguet F, Jackson PK, Yamasaki L, Pagano M.
Dev Cell. 2003 Jun;4(6):799-812.

Publication list