Guardavaccaro group

Ubiquitin ligases and cancer

The ubiquitin-proteasome system controls molecular networks that underlie fundamental cellular functions such as DNA replication, DNA repair, transcription, protein synthesis, cell differentiation and apoptosis. A large body of experimental and clinical data reveals that aberrations in the ubiquitin-dependent protein degradation are intimately linked with cancer pathogenesis. The main objective of our research is the elucidation of the molecular mechanisms by which deregulated function of Cullin-RING ubiquitin ligases contribute to oncogenesis. To this end we use an interdisciplinary approach that includes biochemical and cellular biological methods as well as mouse genetics.

Group

About the research

Key publications

Guardavaccaro, D., Frescas, D., Dorrello, N.V., Peschiaroli, A., Multani, A.S., Cardozo, T., Lasorella, A., Iavarone, A., Chang, S., Hernando, E., Pagano, M. (2008) Control of chromosome stability by the βTrCP-REST-Mad2 axis. Nature 452: 365-370.

Dorrello, N.V., Peschiaroli, A., Guardavaccaro, D., Colburn, N.H., Sherman, N.E., Pagano, M. (2006)
S6K1- and βTrCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 314: 467-471.

Lasorella, A., Stegmüller, J.,  Guardavaccaro, D., Liu, G., Carro, G. Rothschild, M.S., de la Torre-Ubieta, L., Pagano, M., Bonni, A., Iavarone, A. (2006) Degradation of Id2 by the Anaphase Promoting Complex couples cell cycle exit and axonal growth. Nature 442: 471-474.

Bashir, T., Dorrello, N.V., Amador, V., Guardavaccaro, D., Pagano, M. (2004) Control of the SCFSkp2-Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase. Nature 428: 190-193.

Guardavaccaro, D., Kudo, Y., Boulaire, J., Barchi, M., Busino, L., Donzelli, M., Yamasaki, L., Pagano, M. (2003) Control of meiotic and mitotic progression by the F-box protein βTrCP1 in vivo. Dev. Cell 4: 799–812.

Publication list