The ubiquitin-proteasome system controls molecular networks that underlie fundamental cellular functions such as DNA replication, DNA repair, transcription, protein synthesis, cell differentiation and apoptosis. A large body of experimental and clinical data reveals that aberrations in the ubiquitin-dependent protein degradation are intimately linked with cancer pathogenesis. The main objective of our research is the elucidation of the molecular mechanisms by which deregulated function of Cullin-RING ubiquitin ligases contribute to oncogenesis. To this end we use an interdisciplinary approach that includes biochemical and cellular biological methods as well as mouse genetics.
About the research
Control of Epithelial Cell Migration and Invasion by the IKKβ- and CK1α-Mediated Degradation of RAPGEF2.
Magliozzi R, Low TW, Weijts BGMW, Cheng T, Spanjaard E, Mohammed S, van Veen A, Ovaa H, de Rooij J, Zwartkruis FJT, Bos JL, de Bruin A, Heck AJR, Guardavaccaro D.
Dev Cell. 2013, in press.
Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.
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See also: Perspective
Control of chromosome stability by the βTrCP-REST-Mad2 axis.
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Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.
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Nature. 2006 Jul 27;442(7101):471-4.
Control of meiotic and mitotic progression by the F-box protein βTrCP1 in vivo.
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