Pluripotent stem cells can divide almost indefinitely and have the unique ability to give rise to every cell type in our body. For this reason, they are the most versatile source of stem cells for (drug) research and transplantation therapy.
The Geijsen group is developing novel stem cell-based methods to study human development and disease and to develop assays for drug-screening, pathway identification and toxicology assessments.
About the research
Chou, Y.F., Chen, H.H., Eijpe, M., Yabuuchi, A., Chenoweth, J.G., Tesar, P., Lu, J., McKay, R.D., Geijsen, N. (2008) The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells. Cell 135: 449-461.
West, J.A., Park, I.H., Daley, G.Q., Geijsen, N. (2006) In vitro generation of germ cells from murine embryonic stem cells. Nat. Protoc. 1: 2026-2036.
Geijsen, N., Horoschak, M., Kim, K., Gribnau, J., Eggan, K., Daley, G.Q. (2004) Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature 427: 148-154.
Geijsen, N., Uings, I.J., Pals, C., Armstrong, J., McKinnon, M., Raaijmakers, J.A., Lammers, J.W., Koenderman, L., Coffer, P.J. (2001) Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. Science 293: 1136-1138.