Group leader

Jacqueline Deschamps

Jacqueline Deschamps obtained her PhD in yeast genetics at the University of Brussels in 1979. After a postdoc in Brussels she did a second postdoc in the laboratory of Inder Verma at the Salk Institute in San Diego, studying the transcriptional regulation of the mouse c-fos proto-oncogene. She then jointed the Hubrecht Institute where she obtained a group leader position in 1987. After some work on the regulation of the Hox genes in EC and ES cells she set up the transgenic facility in 1990 and analyzed the regulation and the function of Hox and related genes using gain and loss of function approaches. She recently uncovered a novel involvement of Hox and Cdx genes in tissue generation, in addition to their long recognized role in the acquisition of positional identity. In parallel with elucidating the genetic network underlying morphogenesis she studied the relationship between Hox gene expression and the clonal descendance of axial cell progenitors in the posterior part of the early embryo. She now follows the contribution of these (Gfp labeled) axial progenitors of mutants and controls after tissue grafting and in vitro embryo culture.

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