We study the role of transcription factors and signaling molecules during morphogenesis in the growing embryo. We focus on the evolutionary conserved Hox and ParaHox gene families, known for their role in the acquisition of antero-posterior identity of axial tissues. We have shown that Hox genes are also involved in embryonic axial growth. We aim at elucidating the genetic network underlying Cdx and Hox action in morphogenesis, using genetic rescue of loss and gain of function phenotypes. We also want to understand the way the cell progenitors of trunk tissues in early embryos depend on transcription factors and signaling pathways.
About the research
van Rooijen C., Simmini S., Bialecka M., Neijts R., van de Ven C., Beck F. and Deschamps J. (2012). Evolutionary conserved requirement of Cdx for post-occipital tissue emergence. Development 139, 2576-2583.
Van de Ven C., Bialecka M., Neijts R., Young, T., Rowland J., Stringer E.,van Rooijen C, Meijlink F., Novoa A., Freund JN., Mallo M., Beck F. and Deschamps J. (2011). Concerted involvement of Hox/Cdx genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development 138, 3451-3462.
Bialecka M., Wilson V and Deschamps (2010). Cdx mutations causing posterior axial truncations do not impair the long term tissue progenitors in the embryonic posterior growth zone. Developmental Biology 347, 228-234.
Mallo M., Wellik D and Deschamps J. (2010). Hox genes as regional designers of the vertebrate body plan. Developmental Biology 344, 7-15.
Young, T., Rowland, J., van de Ven, C., Bialecka, M., Novoa, A., Carapuco, M., van Nes, J., de Graaff, W., Duluc, I., Freund, JN., Beck, F., Mallo, M. and Deschamps, J. (2009). Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Developmental Cell 17, 516-526.
Young T., and Deschamps J. (2009) Hox and Cdx genes in axial extension and patterning in the mouse embryo. Cur. Topics in Genetics and Development 88, 33-53.
Van Nes J., Lebrin F., Gerhard M., Beck F., and Deschamps J. (2006). The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice. Development 133, 419-428.
Deschamps J. and Van Nes J. (2005). Developmental regulation of the Hox genes during axial morphogenesis in the mouse. Development 132, 2931-2942.