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Deschamps group

Genetics of morphogenesis during axial elongation in the mouse embryo

We study the role of transcription factors and signaling molecules during morphogenesis in the growing embryo. We focus on the evolutionary conserved Hox and ParaHox gene families, known for their role in the acquisition of antero-posterior identity of axial tissues. We study the early transcriptional regulation of these genes using genomic approaches. In addition, we recently showed that Hox genes are also involved in embryonic axial growth. We aim at elucidating the genetic network underlying Cdx and Hox action in morphogenesis, using genetic rescue of loss of function phenotypes. We also want to understand the way the cell progenitors of trunk tissues in early embryos depend on transcription factors and signaling pathways.  

About the research

Key publications

Simmini S., Bialecka M., Huch M., Kester L., van de Wetering M., Sato T., Beck F., van Oudenaarden A., Clevers H. and Deschamps J. (2014). Transformation of intestinal stem cells into gastric stem cells upon loss of transcription factor Cdx2. Nature Communications, Dec 11; 5: 5728.

Neijts R., Simmini S., Giuliani F., van Rooijen C and Deschamps J. (2014) Region-Specific Regulation of Posterior Axial Elongation During Vertebrate Embryogenesis Dev. Dynamics 243, 88-98.

Stringer E.J., Duluc I., Saandi T., Davidson I., Bialecka M., Sato T., Barker N., Clevers H., Protchard C., Winton D.J., Wright N.A., Freund J-N., Deschamps J and Beck F. (2012). Cdx2 detremines the fate of postnatal intestinal endoderm. Development 139, 465-474.

van Rooijen C., Simmini S., Bialecka M., Neijts R., van de Ven C., Beck F. and Deschamps J. (2012). Evolutionary conserved requirement of Cdx for post-occipital tissue emergence. Development 139, 2576-2583.

Van de Ven C., Bialecka M., Neijts R., Young, T., Rowland J., Stringer E.,van Rooijen C, Meijlink F., Novoa A., Freund JN., Mallo M., Beck F. and Deschamps J. (2011). Concerted involvement of Hox/Cdx genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development 138, 3451-3462.

Bialecka M., Wilson V and Deschamps (2010). Cdx mutations causing posterior axial truncations do not impair the long term tissue progenitors in the embryonic posterior growth zone. Developmental Biology 347, 228-234.

Young, T., Rowland, J., van de Ven, C., Bialecka, M., Novoa, A., Carapuco, M., van Nes, J., de Graaff, W., Duluc, I., Freund, JN., Beck, F., Mallo, M. and Deschamps, J. (2009). Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Developmental Cell 17, 516-526.

Young T., and Deschamps J. (2009) Hox and Cdx genes in axial extension and patterning in the mouse embryo. Cur. Topics in Genetics and Development 88, 33-53. .

Deschamps J. and Van Nes J. (2005). Developmental regulation of the Hox genes during axial morphogenesis in the mouse. Development 132, 2931-2942.

Publication list