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de Rooij group

Sijbers, A. M., de Laat, W. L., Ariza, R. R., Biggerstaff, M., Wei, Y. F., Moggs, J. G., Carter, K. C., Shell, B. K., Evans, E., de Jong, M. C., Rademakers, S., de Rooij, J., Jaspers, N. G., Hoeijmakers, J. H., and Wood, R. D.
Xeroderma pigmentosum group F caused by a defect in a structure- specific DNA repair endonuclease.
Cell. 1996 Sep 6; 86 ( 5 ): 811-22 .
de Rooij, J., and Bos, J. L.
Minimal Ras-binding domain of Raf1 can be used as an activation- specific probe for Ras.
Oncogene. 1997 Feb 6;14(5):623-5.
van Weering, D. H., de Rooij, J., Marte, B., Downward, J., Bos, J. L., and Burgering, B. M.
Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.
Mol Cell Biol. 1998 Apr;18(4):1802-11.
de Rooij, J.*, Zwartkruis, F. J.*, Verheijen, M. H., Cool, R. H., Nijman, S. M., Wittinghofer, A., and Bos, J. L.
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.
Nature. 1998 Dec 3; 396 ( 6710 ): 474-7 .
de Rooij, J., Boenink, N. M., van Triest, M., Cool, R. H., Wittinghofer, A., and Bos, J. L. PDZ-GEF1, a Guanine Nucleotide Exchange Factor Specific for Rap1 and Rap2.
J Biol Chem. 1999 Dec 31; 274 ( 53 ): 38125-30 .
de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL.
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.
J Biol Chem. 2000 Jul 7;275(27):20829-36.
de Bruyn KM, de Rooij J, Wolthuis RM, Rehmann H, Wesenbeek J, Cool RH, Wittinghofer AH, Bos JL.
RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral.
J Biol Chem. 2000 Sep 22; 275 ( 38 ): 29761-6 .
van Triest M, de Rooij J, Bos JL.
Measurement of GTP-bound Ras-like GTPases by activation-specific probes.
Methods Enzymol. 2001; 333 : 343-8 .
Kraemer A, Rehmann HR, Cool RH, Theiss C, de Rooij J, Bos JL, Wittinghofer A.
Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1.
J Mol Biol. 2001 Mar 9;306(5):1167-77.
Bos JL, de Rooij J, Reedquist KA.
Rap1 signalling: adhering to new models.
Nat Rev Mol Cell Biol. 2001 May; 2 ( 5 ): 369-77 .
Enserink, JM*, Christensen AE*, De Rooij J*, Van Triest MH, SchwedeF, Genieser HG, Døskeland SO, Blank JL, Bos JL.
(2002) A novel Epac-specific cAMP analogue demonstrates independent regulation
of Rap1 and ERK
Nat Cell Biol 2002 Nov;4(11):901-6

Rehmann H, Prakash B, Wolf E, Rueppel A, De Rooij J, Bos JL, Wittinghofer A.
Structure and regulation of the cAMP-binding domains of Epac2.
Nat Struct Biol 2003 Jan;10(1):26-32

Bos JL, De Bruyn K, Enserink J, Kuiperij B, Rangarajan S, Rehmann H, Riedl J, De Rooij J, Van Mansfeld F, Zwartkruis F.
The role of Rap1 in integrin-mediated cell adhesion.
Biochem Soc Trans 2003 Feb;31(Pt 1):83-6

Rangarajan S, Enserink JM, Kuiperij HB, de Rooij J, Price LS, Schwede F, Bos JL.
Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor.
J Cell Biol 2003 Feb 17;160(4):487-93

Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ.
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.
Biochim Biophys Acta 2003 Feb 17;1593(2-3):141-9

De Bruyn KM, Zwartkruis FT, De Rooij J, Akkerman JW, Bos JL.
The small GTPase Rap1 is activated by turbulence and involved in integrin alpha IIbbeta 3-mediated cell adhesion in human megakaryocytes.
J Biol Chem. 2003 Jun 20;278(25):22412-7.
Christensen AE, Selheim F, de Rooij J, Dremier S, Schwede F, Dao KK, Martinez A, Maenhaut C, Bos JL, Genieser HG, Doskeland SO.
cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension.
J Biol Chem. 2003 Sep 12;278(37):35394-402.
Pellis-van Berkel W, Verheijen MH, Cuppen E, Asahina M, de Rooij J, Jansen G, Plasterk RH, Bos JL, Zwartkruis FJ.
Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity.
Mol Biol Cell. 2005 Jan;16(1):106-16
De Rooij J, Kerstens A, Danuser G, Schwartz MA, Waterman-Storer CM.
Integrin-dependent acto-myosin contraction regulates epithelial cell scattering.
J Cell Biol. 2005 Oct 10;171(1):153-64.
Grande-Garcia A, Echarri A, de Rooij J, Alderson NB, Waterman-Storer CM, Valdivielso JM, del Pozo MA.
Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases.
J Cell Biol. 2007 May 21;177(4):683-94.
Pegtel DM, Ellenbroek SI , Mertens AE , van der Kammen RA , de Rooij J , Collard JG .
The Par-Tiam1 Complex Controls Persistent Migration by Stabilizing Microtubule-Dependent Front-Rear Polarity.
Curr Biol. 2007 Oct 9; 17 ( 19 ): 1623-34
van den Bout I, van Rheenen J, van Angelen AA, de Rooij J, Wilhelmsen K, Jalink K, Divecha N, Sonnenberg A.
Investigation into the mechanism regulating MRP localization.
Exp Cell Res. 2008 Jan 15; 314 ( 2 ): 330-41
Lyle KS, Raaijmakers JH, Bruinsma W, Bos JL, de Rooij J.
cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics.
Cell Signal. 2008 Jun; 20 ( 6 ): 1104-16 .

Le Duc Q, Shi Q, Blonk I, Sonnenberg A, Wang N, Leckband D, de Rooij J.
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner.
J Cell Biol. 2010 Jun 28;189(7):1107-15.

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