Publications
de Laat group
Simonis, M., Klous, P., Homminga, I., Galjaard, RJ., Grosveld, F., Meijerink, JP., de Laat, W. (2009). High-resolution identification of balanced and chromosomal rearrangements by 4C technology. Nat. Methods 6: 837-42.
Louwers, M., Splinter, E., van Driel, R., de Laat, W., Stam, M. (2009) Studying physical chromatin interactions in plants using Chromosome Conformation Capture (3C). Nat. Protoc. 4:1216-19.
Louwers, M., Bader, R., Haring, M., van Driel, R., de Laat, W., Stam, M. Tissue- and expression level-specific chromatin looping at maize b1 epialleles. Plant Cell. 21: 832-42.
Simonis, M., de Laat, W. (2008) FISH-eyed and genome-wide views on the spatial organisation of gene expression. Biochim Biophys Acta. 1783:2052-60.
Noordermeer D, de Laat W. (2008) Joining the loops: beta-Globin gene regulation. IUBMB Life. 60:824-33.
Guelen, L., Pagie, L., Brasset, E., Meuleman, W., Faza, M.B., Talhout, W., Eussen, BH, de Klein, A., Wessels, L., de Laat, W., van Steensel, B. (2008) Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. Nature 453:948-51.
Noordermeer, D., Branco, M.R., Splinter, E., Klous P., van IJcken W., Swagemakers, S., Koutsourakis, M., van der Spek P., Pombo A., and de Laat, W (2008). Transcription and chromatin organization of a housekeeping gene cluster containing an integrated b-globin Locus Control Region. PLOS Genetics 4:e1000016.
Palstra, R.J., Simonis, M., Klous, P., Brasset, E., Eijkelkamp, B. and de Laat, W. (2008). Maintenance of Long-Range DNA Interactions after Inhibition of Ongoing RNA Polymerase II Transcription. PLOS One3(2):e1661
de Laat, W., Klous, P., Kooren, J., Noordermeer,. D, Palstra, R-J., Simonis, M., Splinter, E., Grosveld, F. (2008) Three-dimensional organisation of gene expression in erythroid cells. Chapter 5, Curr Top Dev Biol.82:117-39.
Palstra, R-J., de Laat, W., Grosveld F. (2008) Beta Globin Regulation and Long Range Interactions. Chapter 4, Adv Genet. 61:107-42.
Simonis M, Kooren J, de Laat W. (2007). An evaluation of 3C-based methods to capture DNA interactions. Nature Methods 4:895-901.
De Laat, W., Grosveld F. (2007). Interchromosomal gene regulation in the mammalian cell nucleus. Current Opinion in Genetics and Development, 17(5):456-64.
Kooren, J., Palstra, RJ., Klous, P., Splinter, E., von Lindern, M., Grosveld, F., de Laat, W. (2007). Beta-globin active chromatin Hub formation in differentiating erythroid cells and in p45 NF-E2 knock-out mice. Journal of Biological Chemistry. 282:16544-52.
De Laat, W. (2007). Long-range DNA contacts: romance in the nucleus? Current Opinion in Cell Biology, 19:317-320.
Hagège, H., Klous, P., Braem C., Splinter, E., Dekker, J., Cathala, G., de Laat, W., Forné, T. (2007) Quantitative analysis of Chromosome Conformation Capture assays (qPCR-3C). Nature Protocols, 2:1722-1733.
Skok, JA., Gisler, R., Novatchkova, M., Farmer, D., de Laat W., Busslinger M. (2007). Reversible contraction by looping of the Tcrb and Tcra loci in rearranging thymocytes. Nature Immunology, 8:378-387.
Simonis, M., Klous, P., Splinter, E., Moshkin, Y., Willemsen, R., de Wit, E., van Steensel, B., de Laat, W. (2006). Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C). Nature Genetics 38:1348-1354.
Splinter, E., Heath, H., Kooren, J., Palstra, R.J., Klous, P., Grosveld, F., Galjart, N., de Laat, W. (2006). CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes & Development 20: 2349-2354.
Drissen, R., Palstra, R.J., Gillemans, N., Splinter, E., Grosveld, F., Philipsen, S., de Laat, W. (2004). The active spatial organisation of the b-globin locus requires the transcription factor EKLF. Genes & Development 18: 2485-2490.
Patrinos, G.P., de Krom, M., de Boer, E., Langeveld, A., Imam, A.M.A, Strouboulis, J., de Laat, W., and Grosveld, F.G. (2004). Multiple interactions between regulatory regions are required to stabilize an active chromatin hub. Genes & Development. 18: 1495-1509.
Splinter E., Grosveld F., de Laat W. (2004). 3C technology: analyzing the spatial organisation of genomic loci in vivo. Methods in Enzymology 375: 493-507.
Palstra R-J., Tolhuis B., Splinter E., Nijmeijer R., Grosveld F., de Laat W. (2003). The beta-globin nuclear compartment in development and erythroid differentiation. Nature Genetics 35, 190-194.
de Laat W., Grosveld F. (2003). Spatial organization of gene expression: the Active Chromatin Hub. Chromosome Research. 5: 447-459.
Tolhuis B., Palstra R-J, Splinter E., Grosveld F., de Laat W. (2002). Looping and interaction between hypersensitive sites in the active beta-globin locus. Molecular Cell 10: 1453-1465.
Winkler, G.S., Sugasawa, K., Eker, A.P., de Laat, W.L., Hoeijmakers, J.H. (2001). Novel functional interactions between nucleotide excision DNA repair proteins influencing the enzymatic activities of TFIIH, XPG, and ERCC1-XPF. Biochemistry 40: 160-165.
de Laat, W.L., Jaspers, N.G.J., and Hoeijmakers, J.H.J. (1999). Molecular mechanism of nucleotide excision repair. Genes & Development 13: 768-785.
de Laat, W.L., Appeldoorn, E., Sugasawa, K., Jaspers, N.G.J., and Hoeijmakers, J.H.J. (1998). DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair. Genes & Development 12: 2598-2609.
de Laat, W.L., Sijbers, A.M., Odijk, H., Japers, N.G.J., and Hoeijmakers, J.H.J. (1998). Mapping of interaction domains between human repair proteins ERCC1 and XPF. Nucl. Acids Res. 26: 4146-4152.
de Laat, W.L., Appeldoorn, E., Jaspers, and N.G.J., Hoeijmakers, J.H.J. (1998). DNA structural elements required for ERCC1-XPF endonuclease activity. J. Biol. Chem. 273: 7835-7842.
van Leeuwen, H.C., Strating, M., Rensen, M., de Laat, W.L., and van der Vliet, P.C. (1997). Linker length and composition influence the flexibility of Oct-1 DNA binding. EMBO J. 16(8): 2043-2053.
Sijbers, A.M.#, de Laat W.L.#, Ariza, R.R.#, Biggerstaff, M.#, Wei, Y.-F., Moggs, J.G., Carter, K.C., Shell,B.K., Evans, E., de Jong, M.C., Rademakers, S., de Rooij J., Jaspers, N.G.J., Hoeijmakers, J.H.J., and Wood, R.D. (1996). (#equal contr.). Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease. Cell 86: 811-82.
Cox, M., van Tilborg, P.J., de Laat W.L., Boelens, R., van Leeuwen, H.C., van der Vliet, P.C., and Kaptein, R. (1995). Solution structure of the Oct-1 POU homeodomain determined by NMR and restrained molecular dynamics. J. Biomol. NMR. 6: 23-32.
Medema R.H., de Laat, W.L., Martin, G.A., McCormick, F., and Bos, J.L. (1992). GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion. Mol. Cell. Biol. 12: 3425-3430.
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