Publications

Cuppen group

Search for publications of Edwin Cuppen in PubMed

<2002 - 2002 - 2003 - 2004 - 2005 - 2006 - 2007 - 2008 - 2009 - 2010

2010

92. Homberg J, Nijman IJ, Kuijpers S, Cuppen E. (2010). Identification of genetic modifiers of behavioral phenotypes in serotonin transporter knockout rats. BMC Genet. 2010 May 7;11(1):37. [Epub ahead of print]

91. Snoeren E, Chan J, Bovens A, Cuppen E, Waldinger M, Olivier B, Oosting R. (2010). Serotonin Transporter Null Mutation and Sexual Behavior in Female Rats: 5-HT1A Receptor Desensitization. J Sex Med. 2010 Apr 26. [Epub ahead of print]

90. Cuppen E. (2010). DNA isolation from rat tail or ear. Cold Spring Harb Protoc. 2010 May;2010(5):pdb.prot5434.

89. Atanur SS, Birol I, Guryev V, Hirst M, Hummel O, Morrissey C, Behmoaras J, Fernandez-Suarez XM, Johnson MD, McLaren WM, Patone G, Petretto E, Plessy C, Rockland KS, Rockland C, Saar K, Zhao Y, Carninci P, Flicek P, Kurtz T, Cuppen E, Pravenec M, Hubner N, Jones SJ, Birney E, Aitman TJ. (2010). The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance. Genome Res. 2010 Apr 29. [Epub ahead of print]

88. Linsen SE, de Wit E, de Bruijn E, Cuppen E. (2010). Small RNA expression and strain specificity in the rat. BMC Genomics 11:249.

87. Wansleeben C, Feitsma H, Montcouquiol M, Kroon C, Cuppen E, Meijlink F. (2010). Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Development. 137:1067-73.

86. Johannes F, Wardenaar R, Colomé-Tatché M, Mousson F, de Graaf P, Mokry M, Guryev V, Timmers HT, Cuppen E, Jansen RC. (2010). Comparing genome-wide chromatin profiles using ChIP-chip or ChIP-seq. Bioinformatics. 26(8):1000-6.

85. Mokry M, Feitsma H, Nijman IJ, de Bruijn E, van der Zaag PJ, Guryev V, Cuppen E. (2010). Accurate SNP and mutation detection by targeted custom microarray-based genomic enrichment of short-fragment sequencing libraries. Nucleic Acids Res. 2010 Feb 17. [Epub ahead of print]

84. Kim K, Warden CH, Griffey SM, Vilches-Moure JG, Hansen S, Cuppen E, Nijman IJ, Chiu S, Stern JS. (2010). Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats. Physiol Genomics. 2010 Feb 16. [Epub ahead of print]

83. Groen EJ, van Es MA, van Vught PW, Spliet WG, van Engelen-Lee J, de Visser M, Wokke JH, Schelhaas HJ, Ophoff RA, Fumoto K, Pasterkamp RJ, Dooijes D, Cuppen E, Veldink JH, van den Berg LH. (2010). FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands. Arch Neurol. 67:224-30

82. van Boxtel R, Gould MN, Cuppen E, Smits BM (2010). ENU Mutagenesis to Generate Genetically Modified Rat Models. Methods Mol Biol. 597:151-67.

81. Mul J, Yi CX, van den Berg SA, Ruiter M, Toonen P, van der Elst M, Voshol PJ, Ellenbroek B, Kalsbeek A, la Fleur SE, Cuppen E. (2010). Pmch expression during early development is critical for normal energy homeostasis. Am J Physiol Endocrinol Metab.298:E477-88

2009

80. de Wit E, Linsen SE, Cuppen E, Berezikov E. (2009). Repertoire and evolution of miRNA genes in four divergent nematode species. Genome Res., 19:2064-2074.

79. Pereira F, Queirós S, Gusmão L, Nijman IJ, Cuppen E, Lenstra JA; the Econogene Consortium, Davis SJ, Nejmeddine F, Amorim A. (2009). Tracing the history of goat pastoralism: new clues from mitochondrial and Y chromosome DNA in North Africa. Mol Biol Evol., 26:2765-2673.

78 Linsen SE, de Wit E, Janssens G, Heater S, Chapman L, Parkin RK, Fritz B, Wyman SK, de Bruijn E, Voest EE, Kuersten S, Tewari M, Cuppen E. Limitations and possibilities of small RNA digital gene expression profiling. Nat Methods 6:474-476.

77. Homberg JR, Mul JD, de Wit E, Cuppen E. (2009) Complete knockout of the nociceptin/orphanin FQ receptor in the rat does not induce compensatory changes in mu, delta and kappa opioid receptors. Neuroscience, 163:308-15.

76. Brittijn SA, Duivesteijn SJ, Belmamoune M, Bertens LF, Bitter W, de Bruijn JD, Champagne DL, Cuppen E, Flik G, Vandenbroucke-Grauls CM, Janssen RA, de Jong IM, de Kloet ER, Kros A, Meijer AH, Metz JR, van der Sar AM, Schaaf MJ, Schulte-Merker S, Spaink HP, Tak PP, Verbeek FJ, Vervoordeldonk MJ, Vonk FJ, Witte F, Yuan H, Richardson MK. (2009) Zebrafish development and regeneration: new tools for biomedical research. Int. J Dev Biol 53:835-850

75. Smith, K.A., Joziasse, I.C., Chocron, S., van Dinther, M., Guryev, V., Verhoeven, M.C., Rehmann, H., van der Smagt, J.J., Doevendans, P.A., Cuppen, E., Mulder, B.J., ten Dijke, P., Bakkers, J. (2009) Dominant-negative ALK2 allele associates with congenital heart defects. Circulation. 119:3062-9.

74. Guryev V. and Cuppen E. (2009). Next-generation sequencing approaches in genetic rodent model systems to study functional effects of human genetic variation. FEBS Lett. 583:1668-1673.
[Journal link]

73. Adamovic, T., McAllister, D., Guryeve, V., Wang, X., Wendt Andrae, J., Cuppen, E., Jacob, H.J, and Sugg, S.L. (2009). Microalterations of inherently unstable genomic regions in rat mammary carcinomas as revealed by long oligonucleotide array comparative genomic hybridization. Cancer Res. 69:5159-5167.

72. Homberg, J, la Fleur, SE, and Cuppen, E. (2009). Serotonin transporter deficiency increases abdobminal fat in female, but not male rats. Obesity, in press

71. de Bruijn E, Cuppen E, and Feitsma H. (2009). Highly efficient ENU Mutagenesis in Zebrafish. Methods Mol Biol. 546:3-12.
[Journal link]

70. Matondo RB, Punt C, Homberg J, Toussaint MJ, Kisjes R, Korporaal SJ, Akkerman JW, Cuppen E, and de Bruin A. (2009). Deletion of the Serotonin Transporter in Rats Disturbs Serotonin Homeostasis Without Impairing Liver Regeneration. Am J Physiol Gastrointest Liver Physiol., 296: G963-G968.
[Journal link]

69. van den Bos R, Homberg J, Gijsbers E, den Heijer E, and Cuppen E. (2009). The effect of COMT Val(158) Met genotype on decision-making and preliminary findings on its interaction with the 5-HTTLPR in healthy females. Neuropharmacology 56:493-498.
[Journal link]

2008

68. van Boxtel, R., Toonen, P.W., Verheul, M., van Roekel, H.S., Nijman, I.J., Guryev, V., and Cuppen, E. (2008). Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals. BMC Genomics, 9:460.
[Journal link]

67. Linsen, S.E.V., Tops, B.B.J., and Cuppen, E. (2008). miRNA's: small changes, widespread effects. Cell Research, 18:1157-9.
[Journal link]

66. Feitsma, H., Akay, A., and Cuppen, E. (2008). Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos. Nucl. Acids Res. 36:4047-4056.
[Journal link] [PDF]

65. Olivier, J.D., Cools, A.R., Olivier, B., Homberg, J.R., Cuppen, E., and Ellenbroek, B.A. (2008). Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: A study in SERT knockout rats. Eur. J. Pharmacol. 590:190-197.
[Journal link]

64. Kruisselbrink, E., Guryev, V., Brouwer, K., Pontier, D.B., Cuppen, E., and Tijsterman, M. (2008). Mutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans. Current Biology, 18:900-905
[Journal link]

63. Homberg, J., de Boer, S., Raaso, H.S., Olivier, J.D.A., Verheul, M., Ronken, E., Cools, A.R., Ellenbroek, B.A., Schoffelmeer, A.N.M., Vanderschuren, L.J.M.J., de Vries, T.J., and Cuppen, E. (2008). Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats. Psychopharmacology, 200:367-380.
[Journal link]

62. Guryev, V., Saar, K., Adamovic, T., Verheul, M., van Heesch, S., Cook, S., Pravenec, M., Aitman, T., Jacob, H., Shull, JD., Hubner, N., and Cuppen, E. (2008). Distribution and functional impact of DNA copy number variation in the rat. Nature Genetics, 40:538-545.
[Journal link]

61. The STAR Consortium: Saar, K., Beck, A., Bihoreau, M., Birney, E., Brocklebank, D., Chen, Y., Cuppen, E., Demonchy, S., Dopazo, J., Flicek, P., Foglio, M., Fujiyama, A., Gut, I.G., Gauguier, D., Guido, R., Guryev, V., Heinig, M., Hummel, O., Jahn, N., Klages, S., Kren, V., Kube, M., Kuhl, H., Kuramoto, T., Kuroki, Y., Lechner, D., Lee, Y., Lopez-Bigas, N., Lathrop, G.M., Mashimo, T., Medina, I., Mott, R., Patone, G., Perrier-Cornet, J., Platzer, M., Pravenec, M., Reinhardt, R., Sakaki, Y., Schilhabel, M., Schulz, H., Serikawa, T., Shikhagaie, M., Tatsumoto, S., Taudien, S., Toyoda, A., Voigt, B., Zelenika, D., Zimdahl, H., and Hubner, N. (2008). SNP and haplotype mapping for genetic analysis in the rat. Nature Genetics, 40:560-566.
[Journal link]

60. Aitman, T.J., Critser, J.K., Cuppen, E., Dominiczak, A., Fernandez-Suarez, X.M., Flint, J., Gauguier, D., Geurts, A.M., Gould, M., Harris, P.C., Holmdahl, R., Hubner, N., Izsvak, Z., Jacob, H.J., Kuramoto, T., Kwitek, A.E. Marrone, A., Tomoji, M., Moreno, C., Mullins, J., Mullins, L., Olsson, T., Pravenec, M., Riley, L., Saar, K., Serikawa, T., Shull, J.D., Szpirer, C., Twigger, S.N., Voigt, B., Worley, K. (2008). Progress and prospects in rat genetics: a community view. Nature Genetics, 40:516-522
[Journal link]

59. Nijman IJ, Kuipers S, Verheul M, Guryev V, and Cuppen E. (2008) A genome-wide SNP panel for mapping and association studies in the rat. BMC Genomics 9:95
[Journal link] [PDF]

58. Feitsma, H., Kuiper, R.V., Korving, J., Nijman, I.J., and Cuppen, E. (2008). Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors. Cancer Research 68: 5059-5066.
[Journal link]

57. van Boxtel, R., Toonen, P., van Roekel, H., Verheul, M., Smits, B.M., Korving, J., de Bruin, A., and Cuppen, E. (2008). Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis. Carcinogenesis, 29:1290-1297.
[Journal link]

56. Homberg, J., van den Bos, R., den Heijer, E., Suer, R., and Cuppen, E. (2008). Serotonin transporter dosage modulates long-term decision-making in rat and human. Neuropharmacology, 55: 80-84.
[Journal link]

55. Nijman, I.J., van Boxtel, D.C.J., van Cann, L.M., Marnoch, Y., Cuppen, E., and Lenstra, J.A. (2008). Phylogeny of Y chromosomes from bovine species. Cladistics 24: 723-726.
[Journal link]

54. Feitsma, H., de Bruijn, E., van de Belt, J., Nijman, I.J., Cuppen, E. (2008). Mismatch repair deficiency does not enhance ENU mutagenesis in the zebrafish germ line. Mutagenesis, 23:325-329
[Journal link] [PDF]

53. Weiss, H., Arndt, T., Jorns, A., Lenzen, S., Cuppen, E., Hedrich, HJ, Fiedge, M., Wedekind, D. (2008). The mutation of the LEW.1AR1-iddm rat maps to the telomeric end of rat chromosome 1. Mamm. Genome, 19:292-297.
[Journal link]

52. Olivier JD, van der Hart MG, van Swelm RP, Dederen PJ, Homberg JR, Cremers T, Deen PM, Cuppen E, Cools AR, Ellenbroek BA. (2008). A study in male and female 5-HT transporter knockout rats: An animal model for anxiety and depression disorders. Neuroscience, 152:573-84.
[Journal link]

51. Smits BM, Haag JD, Gould MN, Cuppen E (2008) Rat Knockout and Mutant Models, In: Sourcebook of Models for Biomedical Research, Editor: Conn MP, Humana Press, Totowa NJ, p171-178

50. Feitsma, H. and Cuppen, E. (2008). Zebrafish as a cancer model. Molecular Cancer Res., 6:685-694
[Journal link]

49. Mokry, M. and Cuppen, E. (2008). The Atp1a1 gene from inbred Dahl salt sensitive rats does not contain the A1079T missense transversion. Hypertension, 51:922-927
[Journal link]

48. Hatzis P, van der Flier LG, van Driel MA, Guryev V, Nielsen F, Denissov S, Nijman IJ, Koster J, Santo EE, Welboren W, Versteeg R, Cuppen E, van de Wetering M, Clevers H, Stunnenberg HG. (2008). Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol. Cell Biol., 28:2732-2744
[Journal link]

47. Leal, M., Feitsma, H., Cuppen, E., Franca, L., and Schulz, R. (2008). Meiosis can be completed in male zebrafish (Danio rerio) lacking the DNA mismatch repair gene mlh1. Cell Tissue Res. 332:133-9.
[Journal link]

2007

46. Berezikov, E., Guryev, V., Cuppen, E. (2007). Exploring Conservation of Transcription Factor Binding Sites with CONREAL. Methods Mol Biol. 395:437-448.

45. Frische EW, Pellis-van Berkel W, van Haaften G, Cuppen E, Plasterk RH, Tijsterman M, Bos JL, Zwartkruis FJ. (2007) RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. EMBO J., 26:5083-5092
[Journal link] [PDF]

44. Berezikov, E., Chung, W.J., Willis, J., Cuppen, E., and Lai, E.C. (2007). Mammalian mirtron genes. Mol. Cell 28:328-336
[Journal link] [PDF]

43. Homberg, J.R., Pattij, T., Janssen, M.C.W., Ronken, E., De Boer, S.F., Schoffelmeer, A.N.M., and Cuppen, E., (2007). Serotonin transporter deficiency in rats improves inhibitory control but not behavioral flexibility. Eur. J. Neurosci., 26:2066-2073
[Journal link] [PDF]

42. Homberg, J.R., Schiepers, O.J., Schoffelmeer, A.N.M., Cuppen, E., Vanderschuren, L.J.. (2007). Acute and constitutive increases in central serotonin levels reduce social play behaviour in peri-adolescent rats. Psychopharmacology, 195:175-182.
[Journal link] [PDF]

41. Homberg, J.R., Olivier, J.D.A., Smits, B.M.G., Mul, J.D., Mudde, J, Verheul, M., Nieuwenhuizen, O.F.M., Cools, A.R., Ronken, E., Cremers, T., Schoffelmeer, A.N.M., Ellenbroek, B.A., and Cuppen, E. (2007). Characerization of the serotonin transporter knockout rat: A selective change in the functioning of the serotonergic system. Neuroscience, 146:1662-1676.
[Journal link] [PDF]

40. Cuppen, E., Gort, E., Hazendonk, E., Mudde, J., v.d. Belt, J., Nijman, I.J., Guryev, V., and Plasterk, R.H.A. (2007). Efficient target-selected mutagenesis in Caenorhabditis elegans: towards a knockout for every gene. Genome Research, 17:649-658
[Journal link] [PDF]

39. Feitsma, H., Leal, M.C., Moens, P.B., Cuppen, E., and Schulz, R.W. (2007). Mlh1 deficiency in zebrafish results in male sterility and aneuploid as well as triploid progeny in females. Genetics, 175:1561-1569
[Journal link] [PDF]

2006

38. Taniguchi, Y., Takeda, S., Furutani-Seiki, M., Kamei, Y., Todo, T., Sasado, T., Deguchi, T., Kondoh, H., Mudde, J., Yamazoe, J., Hidaka, M., Mitani, H., Toyoda, A., Sakaki, Y., Plasterk, R., and Cuppen, E. (2006). Generation of medaka gene knockout models by target-selected mutagenesis. Genome Biology, 7:R116
[Journal link] [PDF]

37. Berezikov. E., Thuemmler, F., van Laake, L., Kondova, I., Bontrop, R., Cuppen, E., and Plasterk, R.H.A. (2006). Diversity of microRNAs in human and chimpanzee brain. Nature Genetics, 38:1375-1377
[Journal link] [PDF]

36. Homberg, J., Mudde, J., Braam, B., Ellenbroek, B., Cuppen, E., and Joles, J.A. (2006). Blood pressure in mutant rats lacking the 5-hydroxytryptamine (5-HT) transporter. Hypertension, 48: e115-116e
[Journal link] [PDF]

35. Takada, S., Berezikov, E., Yamashita, Y., Lagos-Quitana, M., Kloosterman, W., Enomoto, M., Hatanaka, H., Fujiwara, S., Watanabe, H., Soda, M., Choi, Y.L., Plasterk, R., Cuppen, E., and Mano H. (2006). Mouse microRNA profilies determined with a new and sensitive cloning method. Nucl. Acid Res., 34: e117.
[Journal link] [PDF]

34. Berezikov, E., van Tetering, G., Verheul, M., van de Belt, J., van Laake, L., Vos, J., Verloop, R., van de Wetering, M., Guryev, V., Takada, S., van Zonneveld, A.J., Mano, H., Plasterk, R.H.A., and Cuppen, E. (2006). Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. Genome Research, 16:1289-1298.
[Journal link] [PDF]

33. Guryev, V., Smits, B.M.G., van de Belt, J., Verheul, M., Hubner, N., and Cuppen, E. (2006). Haplotype Block Structure Is Conserved
across Mammals. PLOS Genetics, 2(7): e121.
[Journal link] [PDF]

32. Berezikov, E., Cuppen, E., and Plasterk, R. (2006). Approaches to microRNA discovery. Nature Genet. 38:, S2-S7.
[Journal link] [PDF]

31. Kloosterman, W., Steiner, F., Berezikov, E., de Bruijn, E., van de Belt, J., Verheul, M., Cuppen, E., and Plasterk, R. (2006). Cloning and expression of new microRNAs from zebrafish. Nucl. Acid Res., 34:2558-2569.
[Journal link] [PDF]

30. Smits, B.M.G. and Cuppen, E. (2006). Rat Genetics: the Next Episode. Trends in Genetics, 22:232-40.
[Journal link] [PDF]

29. Smits, B.M.G. and Cuppen, E. (2006). Rats go genomic. Genome Biology, 7:306
[Journal link] [PDF]

28. Guryev, V., Koudijs, M.J., Berezikov, E., Johnson, S.L., Plasterk, R.H.A., van Eeden, F.J.M., and Cuppen, E. (2006). Genetic Variation in the Zebrafish. Genome Research, 16 491-497.
[Journal link] [PDF]

27. Smits, B.M.G., Mudde, J.B., van de Belt, J., Verheul, M., Olivier, J., Homberg, J., Guryev, V., Cools, A.R., Ellenbroek, B.A., Plasterk, R.H.A., and Cuppen, E. (2006). Generation of Gene Knockouts and Mutant Models in the Laboratory Rat by ENU-driven Target-Selected Mutagenesis. Pharmacogenetics and Genomics, 16(3):159-169.
[PDF]

2005

26. Smits, B.M.G., Guryev, V., Zeegers, D., Wedekind, D., Hedrich, H.J., and Cuppen, E. (2005). Efficient Single Nucleotide Polymorphism Discovery in Laboratory Rat Strains using Wild Rat-derived SNP Candidates. BMC Genomics, 6:170.
[Abstract] [PDF]

25. Smits, B.M.G., Peters, T.A., Mul, J.D., Croes, H.J., Fransen, J.A.M., Beynon, A.J., Guryev, V., Plasterk, R.H.A, and Cuppen, E. (2005). Identification of a rat model for Usher syndrome type 1B by ENU mutagenesis-driven forward genetics. Genetics, 70:1887-1896
[PDF] [Supplemental files and movies]

24. Berezikov, E., Guryev, V., and Cuppen, E. (2005). CONREAL Web Server: Identification and Visualization of Conserved Transcription Factor Binding Sites. Nucl. Acid Res., 33:W447-W450.
[PDF] [Webinterface]

23. Cuppen, E. (2005). Haplotype-based genetics in mice and rats. Trends Genet., 21:318-322.
[Journal link] [PDF]

22. Guryev, V., Berezikov, E., and Cuppen, E. (2005). CASCAD: a database of annotated candidate single nucleotide polymorphisms associated with expressed sequences. BMC Genomics,6(1):10
[PDF] [Journal link] [Webinterface]

21. Berezikov, E., Guryev, V., Belt, J. v.d., Wienholds, E., Plasterk, R.H.A, and Cuppen, E. (2005). Phylogenetic Shadowing and Computational Identification of Human microRNA Genes. Cell, 120:21-24
[Journal link] [PDF] [Supplemental Data]

20. van Berkel, W.P., Verheijen, M.H., Cuppen, E., Asahina, M., de Rooij, J., Jansen, G., Plasterk, R.H., Bos, J.L., Zwartkruis, F.J. (2005) Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for Epithelial Integrity. Mol Biol Cell., 16:106-116
[PDF]

2004

19. Guryev, V., Berezikov, E., Malik, R., Plasterk, R.H.A., and Cuppen, E. (2004) Single Nucleotide Polymorphisms associated with rat expressed sequences. Genome Research, 14:1438-1443.
[PDF] [Supplemental Data] [Webinterface]

18. Smits, B.M.G., van Zutphen, B.F.M., Plasterk, R.H.A, and Cuppen, E. (2004) Genetic variation in coding regions between and within commonly used inbred rat strains. Genome Research, 14:1285-1290
[PDF] [Supplemental Data]

17. Smits, B.M.G., D'Souza, U.M., Berezikov, E., Cuppen, E., Sluyter, F. (2004) Identifying polymorphisms in the Rattus norvegicus D3 dopamine receptor gene and regulatory region. Genes Brain Behav., 3: 138-148.
[PDF] [Supplemental Data]

16. Smits, B.M.G., Mudde, J., Plasterk, R.H.A., and Cuppen E. (2004). Target-selected mutagenesis of the rat. Genomics, 83:332-334.
[PDF]

15. Berezikov, E., Guryev, V., Plasterk R.H.A., and Cuppen, E. (2004). CONREAL: Conserved Regulatory Elements Anchored Alignment Algorithm for Identification of Transcription Factor Binding Sites by Phylogenetic Footprinting. Genome Research, 14:170-178.
[PDF] [Supplemental Data] [webinterface]

2003

14. Wienholds, E., van Eeden, F., Kosters, M., Mudde, J., Plasterk, R.H.A., and Cuppen, E. (2003). Efficient target-selected mutagenesis in zebrafish. Genome Research, 13:2700-2707.
[PDF] [Supplemental Data]

13. Wienholds, E., Koudijs, M., van Eeden, F., Cuppen, E., and Plasterk, R.H.A. (2003). The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nature Genetics, 35:217-128.
[PDF] [Supplemental Data]

12. Hurlstone, A. F. L., Haramis, A.-P. G., Wienholds, E., Begthel, H., Eeden, F. v., Cuppen, E., Zivkovic, D., Plasterk, R. H. A., and Clevers, H. (2003). The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature, 425:633-637.
[PDF] [Supplemental Data]

11. Cuppen, E., Van der Linden, A.M., Jansen, G., and Plasterk, R.H.A. (2003). Proteins interacting with Caenorhabdites elegans G-alpha subunits. Comp. Funct. Genomics, 4:479-491.
[PDF]

10. Van der Linden, A.M., Moorman, C., Cuppen, E., Korswagen, H.C., Plasterk, R.H.A. (2003). Hyperactivation of the G(12)-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via Protein Kinase C. Curr Biol., 13:516-21 .
[PDF]

2002

9. Berezikov, E., Plasterk, R.H.A., and Cuppen, E. (2002). GENOTRACE: cDNA-based local GENOme assembly from TRACE archives. Bioinformatics, 18:1396-7.
[PDF] [webinterface]

before 2002

8. Chan M.F., van Amerongen R., Nijjar T., Cuppen E., Jones P.A., Laird P.W. (2001). Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells. Mol Cell Biol., 21:7587-600.
[PDF]

7. van der Linden, A.M., Simmer, F., Cuppen E., and Plasterk, R.H.A. (2001). The G protein beta subunit GPB-2 in Caenorhabditis elegans regulates the Go(alpha)-Gq(alpha) signaling network through interactions with the RGS proteins EGL-10 and EAT-16. Genetics, 158:221-35.
[PDF]

6. Cuppen, E., van Ham, M., Wansink, D.G., Leeuw, A. de, Wieringa, B. and Hendriks, W. (2000). The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL. Eur J Cell Biol., 79:283-93.

5. Cuppen, E., Wijers, M., Schepens, J., Fransen, J., Wieringa, B. and Hendriks, W. (1999). A FERM domain governs apical confinement of PTP-BL in epithelial cells. J Cell Sci., 112:3299-308.

4. Cuppen, E., Van Ham, M., Pepers, B., Wieringa, B. and Hendriks, W. (1999). Identification and molecular characterization of BP75, a novel bromodomain-containing protein. FEBS Lett., 459:291-8.

3. Cuppen, E., Gerrits, H., Pepers, B., Wieringa, B. and Hendriks, W. (1998). PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL. Mol. Biol. Cell, 9:671-83.

2. Cuppen, E., Nagata, S., Wieringa, B. and Hendriks, W. (1997). No evidence for involvement of mouse protein-tyrosine phosphatase-BAS-like / Fas-associated phosphatase-1 in Fas-mediated apoptosis. J. Biol. Chem., 272:30215-20.

1. Schepens, J., Cuppen, E. and Hendriks, W. (1997). The neuronal nitric oxide synthase PDZ motif binds to -GDXV* carboxyterminal sequences. FEBS Lett., 409:53-6.

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