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Berezikov group

Small RNAs and regeneration

Dr. Eugene Berezikov has been appointed at the European Research Institute for the Biology of Aging (ERIBA) at the University Medical Center Groningen. Most of the Berezikov group has moved to Groningen as per 1 August 2012. The new contact details can be found at the group leader page
A number of group members remain at the Hubrecht Institute to finish their projects.



MicroRNAs and other small RNAs are now recognized as key regulators of various cellular processes but their specific functions are largely unknown. We combine computational and experimental approaches to study the repertoire, biological roles and evolution of small RNAs in animals and plants. In the nematode C. elegans we study how miRNAs contribute to the development, homeostasis, stress responce and aging. In the flatworm Macrostomum lignano – an emerging model organism for regeneration and stem cell research – we are developing genomic tools and resources, including de novo genome sequencing and annotation, to study roles of small RNAs in the maintenance and differentiation of neoblasts (see www.macgenome.org for details).

About the research

Fast Facts: Genomics' next top model from Fast Facts on Vimeo.


Key publications

Demircan, T., Berezikov, E. (2013) The hippo pathway regulates stem cells during homeostasis and regeneration of the flatworm Macrostomum lignano. Stem Cells Dev. 22: 2174-2185.

Simanov, D., Mellaart-Straver, I., Sormacheva, I., Berezikov, E. (2012) The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research. Stem Cells Int. 2012: 167265.

Berezikov, E. (2011) Evolution of microRNA diversity and regulation in animals. Nat Rev Genet. 12: 846-860.

Berezikov, E. Liu, N., Flynt, A.S., Hodges, E., Rooks, M. Hannon, G.J., Lai, E.C. (2010) Evolutionary flux of canonical microRNAs and mirtrons in Drosophila. Nat. Genet. 42: 6-9.

Berezikov, E., Guryev, V., van de Belt, J., Wienholds, E., Plasterk, R.H.A, Cuppen, E. (2005) Phylogenetic shadowing and computational identification of human microRNA genes. Cell 120: 21-24.

Publication list