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Bakkers group

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1. Tessadori, F., Noël, E.S., Rens, E.G., Magliozzi, R., Evers-van Gogh, I.J.A., Guardavaccaro, D., Merks, R.M.H. and Bakkers, J. Nodal signalling range is regulated by proprotein convertase-mediated secretion. Dev. Cell epub Februari 12

Junker, J.P., Noël, E.S., Guryev, V., Peterson, K.A., Shah, G., Huisken, J., McMahon, A.P., Berezikov, E., Bakkers, J. * and van Oudenaarden, A.* Genome-wide RNA tomography in the zebrafish embryo. Cell 159(3): 662-675 *shared corresponding authors

Chetaille, P., Côté, j., Burkhard, S., Houde, C., Preuss, C., Piché, J.,Gosset, N., Leclerc, S., Wünnemann, F., Cameron, M., Castilloux, J., Thibeault, M., Gagnon, C., Galli, A., Tuck, A., Hickson, G., Amine, N., Boufaied, I., Lemyre, E.,Santa Barbara, P., Faure, S., Jonzon, A., Dietz, H., Gallo-McFarlane, E., Benson, W., Zhan, S.H., Shen, Y., Jomphe, M., Jones, S.J.M., Bakkers, J., and Andelfinger, G. A human dysrhythmia syndrome affecting heart and gut is associated with mutations in SGOL1. Nat. Genet. 46(11):1245-9

Bonetti, M., Paardekoper Overman, J., Tessadori, F., Noël, E.S., Bakkers, J. and den Hertog J. (2014) Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish. Development 141(9):1961-70.

Noël ES, Verhoeven M, Lagendijk AK, Tessadori F, Smith K, Choorapoikayil S, den Hertog J and Bakkers J. A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality. Nat. Commun. 4:2754

Goudarzi, M., Strate, I., Paksa, A., Lagendijk, A.K., Bakkers, J. and Raz, E. On the robustness of germ cell migration and miRNA-mediated regulation of chemokine signaling. Nat. Genet. 45(11):1264-5

Mugoni, V., Postel, R., Catanzaro, V., De Luca, E., Turco, E., Digilio, G., Silengo, Murphy, M.P., Medana, C., L., Stainier, D.Y.R., Bakkers, J. and Santoro, M.M. (2013) Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis. Cell 152; 504-518

Lagendijk, A.K., Szabo, A., Merks, R.M.H. and Bakkers J. Hyaluronan: A critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation. Trends Cardiovasc. Med. in press

Goudarzi, M., Banisch, T.U., Mobin, M.B., Maghelli, N., Tarbashevich, K., Strate, I., van den Berg, J., Blaser, H., Bandemer, S., Paluch, E., Bakkers, J., Tolić-Nørrelykke, I.M. and Raz, E. (2012) Identification and regulation of a molecular module for bleb-based cell motility. Dev. Cell 23(1):210-218

Tessadori, F., van Weerd, J.H., Burkhard, S.B., Verkerk, A.O., de Pater, E., Boukens, B.J., Vink, A., Christoffels, V.M., Bakkers, J. Identification and functional characterization of cardiac pacemaker cells in zebrafish. PLoS One. 7(10):e47644

Hyde, A.S., Farmer, E.L., Easley, K.E., van Lammeren, K., Christoffels, V.M., Barycki, J.J., Bakkers, J and Simpson, M.A. UDP-glucose Dehydrogenase Polymorphisms from Patients with Congenital Heart Valve Defects Disrupt Enzyme Stability and Quaternary Assembly. J Biol Chem. 287(39):32708-16

Boogaard, M., Wong, L.Y.E., Tessadori, F., Bakker, M.L., Dreizehnter, L.K., Wakker, V., Bezzina, C.R., ‘t Hoen, P.A.C., Bakkers, J., Barnett, P. and Christoffels, V.M. (2012) Genome-wide identification of cardiac T-box factor targets reveals an Scn5a/10a enhancer functionally affected by a genetic variation. J. Clin. Invest. 122(7): 2519-2530

Lagendijk, A.K., Moulton, J.D. and Bakkers, J. (2012) Revealing details: whole mount microRNA in situ hybridization protocol for zebrafish embryos and adult tissues. Biology Open 1(6): 566-569

de Pater, E., Ciampricotti, M., Priller, F., Veerkamp, Strate, I., Smith, K., Lagendijk, A.K., Schilling, T.F., J., Herzog, W., Abdelilah-Seyfried, S., Hammerschmidt, M. and Bakkers, J. Bmp signaling exerts opposing effects on cardiac differentiation. Circ. Res. 110: 578-587


Smith, K., Noël, E., Thurlings, I., Rehmann, H., Chocron, S. and Bakkers, J. (2011) Bmp and Nodal Independently Regulate lefty1 Expression to Maintain Unilateral Nodal Activity During Left-Right Axis Specification in Zebrafish. PloS Gen. 7(9):e1002289

Smith, K., Lagendijk, A.K., Courtney, A., Chen, H., Paterson, S., Hogan, B.M., Wicking, C. and Bakkers, J. (2011) Transmembrane protein 2 (tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development. Development 38:4193-8.

Lagendijk AK, Goumans MJ, Burkhard SB, Bakkers J. (2011) MicroRNA-23 Restricts Cardiac Valve Formation by Inhibiting Has2 and Extracellular Hyaluronic Acid Production. Circ. Res. 109:649-657

Ghani S, Riemke P, Schönheit J, Lenze D, Stumm J, Hoogenkamp M, Lagendijk A, Heinz S, Bonifer C, Bakkers J, Abdelilah-Seyfried S, Hummel M, Rosenbauer F. (2011) Macrophage development from HSCs requires PU.1-coordinated microRNA expression. Blood 118:2275-2284

Bakkers, J. (2011) Zebrafish as a model to study cardiac development and human cardiac disease. Cardiovascular Res. 91:279-288 doi: 10.1093/cvr/cvr098. 

Boogerd CJ, Wong LY, van den Boogaard M, Bakker ML, Tessadori F, Bakkers J, 't Hoen PA, Moorman AF, Christoffels VM, Barnett P. (2011) Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43. Cell Mol Life Sci. 68:3949–3961

Vehoeven, M., Haase, C., Christoffels, V.M., Weidinger, G. and Bakkers, J. (2011) Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2. Birth Defects Research Part A: Clinical and Molecular Teratology 91(6):435-440

Joziasse, I.C., Smith, K., Chocron, S., van Dinther, M., Guryev, V., van der Smagt, J.J., Cuppen, E., Ten Dijke, P., Mulder, B.J., Maslen, C.L., Reshey, B., Doevendans, P. and Bakkers, J. (2011) ALK2 mutation in a patient with Down syndrome and a congenital heart defect. Eur. J. Human Genetics. 19(4):389-393

Lagendijk, A.K., Smith, K. and Bakkers, J. (2011). Genetics of congenital heart defects: A candidate gene approach. Trends in Cardiovascular Research 20(4):124-128

Beqqali A, Monshouwer-Kloots J, Monteiro R, Welling M, Bakkers J, Ehler E, Verkleij A, Mummery C, Passier R. (2010) CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. J Cell Sci. 123(Pt 7):1141-50

Smith K.A., Joziasse I.C., Chocron S., van Dinther M., Guryev V., Verhoeven M.C., Rehmann H., van der Smagt J.J., Doevendans P.A., Cuppen E., Mulder B.J., Ten Dijke P., Bakkers J. (2009) Dominant-negative ALK2 allele associates with congenital heart defects. Circulation 119(24):3062-3069

Bakkers J, Verhoeven MC and Abdelilah-Seyfried S. (2009) Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis. Dev. Biol. 330(2):213-20 Review article

de Pater E, Clijsters L, Marques S, Lin Y, Garavito-Aguilar ZV, Yelon D and Bakkers J. (2009) Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart. Development 136(10):1633-41

Marques IJ, Weiss FU, Vlecken DH, Nitsche C, Bakkers J, Lagendijk AC, Partecke LI, Heidecke C, Lerch MM and Bagowski CP (2009) Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model. BMC Cancer 9:128

Postel R, Vakeel P, Topczewski J, Knöll R, Bakkers J. (2008) Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex. Dev Biol.318(1):92-101

Joziasse IC, van de Smagt JJ, Smith K, Bakkers J, Sieswerda GJ, Mulder BJ and Doevendans PA.(2008) Genes in congenital heart disease: atrioventricular valve formation. Basic Res Cardiol. 103(3):216-27

Krens SF, He S, Lamers GE, Meijer AH, Bakkers J, Schmidt T, Spaink HP and Snaar-Jagalska BE.(2008) Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation.Dev Biol.15;319(2):370-83

Smith KA, Chocron S, von der Hardt S, de Pater E, Soufan A, Bussmann J, Schulte-Merker S, Hammerschmidt M and Bakkers J. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells Dev Cell, 14; 287–297

Monteiro R, van Dinther M, Bakkers J, Wilkinson R, Patient R, Ten Dijke P and Mummery C.(2008) Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Dev Biol. 315(1):55-71

Bussmann J, Bakkers J, Schulte-Merker S.(2007). Early endocardial morphogenesis requires Scl/Tal1.PLoS Genetics, 3(8):e140.

Knoell R, Postel R, Wang J, Kraetzner R, Hennecke G, Murthy K, Rana B, Kube D, Knoell G, Schaefer K, Hayashi T, Kimura A, Schork N, Toliat M, Nuernberg P, Schultheiss P, Schaper W, Schaper J, Bos E, Van Eeden F, Peters P, Hasenfuss G, Chien K, and Bakkers J (2007). Laminin alpha 4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and in endothelial cells. Circulation, 116(5):515-25

Chocron S, Verhoeven M.C, Rentzsch F. Hammerschmidt M. and Bakkers J. (2007). Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points. Dev. Biol., 15;305(2):577-88

von der Hardt S, Bakkers J, Inbal A, Carvalho L, Solnica-Krezel L, Heisenberg CP, and Hammerschmidt M (2007).  The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating Ca2+-dependent cell adhesiveness. Current Biology, 17(6):475-87.

Thijssen VL, Postel R, Brandwijk RJ, Dings RP, Nesmelova I, Satijn S, Verhofstad N, Nakabeppu Y, Baum LG, Bakkers J, Mayo KH, Poirier F, Griffioen AW. (2006) Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proc Natl Acad Sci U S A, 103(43): 15975-15980

Meer van der D.L.M., Marques I.J., Leito J.T.D., Besser J., Bakkers J., Schoonheere E. and Bagowski. C.P. (2006) Zebrafish cypher is important for somite formation and heart development. Dev. Biol., 299(2):356-72

J. Bakkers, M. Camacho-Carvajal, M. Nowak, C. Kramer, B. Danger and M. Hammerschmidt (2005). Destabilization of deltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo.Cell Cycle. 2005 Jun;4(6):790-800

Rentzsch,F., Bakkers,J., Kramer,C. and Hammerschmidt,M. (2004) Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition. Dev. Dyn. 231: 750-757

Brembeck,F.H., Schwarz-Romond,T., Bakkers,J., Wilhelm,S., Hammerschmidt,M. and Birchmeier,W. (2004) Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. Genes Dev . 18(18):2225-2230

Bakkers,J., Kramer,C., Pothof,J., Quaedvlieg,N.E.M., Spaink,H.P. and Hammerschmidt,M. (2004) Hyaluronan synthase 2 (Has2) is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Development 132: 525-537

Schwarz-Romond,T., Asbrand,C., Bakkers,J., Kühl,M., Schaeffer,H., Huelsken,J., Behrens,J., Hammerschmidt,M. and Birchmeier,W (2002). The ankyrin repeat protein Diversin recruits Casein Kinase I epsilon to the b-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev. 16(16):2073-84

Bakkers,J., Hild,M., Kramer,C., Furutani-Seiki,M. and Hammerschmidt,M. (2002). Zebrafish deltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm. Dev Cell. ; 2(5):617-27

Lele,Z., Bakkers,J. and Hammerschmidt,M. (2001). Morpholino phenocopies of the swirl/bmp2b, snailhouse/bmp7, somitabun/smad5, minifin/tolloid, silberblick/wnt11 and pipetail/wnt5 mutations. Genesis 30: 190-194

Bakkers,J., Kijne,J.W. and Spaink,H.P. (1999). Function of chitin oligosaccharides in plant and animal development. In Chitin and chitinases, R.A.A. Muzzarelli and P. Jollès, eds. (Basel/Switzerland: Birkhäuser Verlag), pp. 69-81.

Kamst,E., Bakkers,J., Quaedvlieg,N.E.M., Pilling,J., Kijne,J.W., Lugtenberg, B.J.J. and Spaink,H.P. (1999). Chitin oligosaccharide synthesis by rhizobia and zebrafish embryos starts by glycosyl transfer to O4 of the reducing-terminal residue. Biochemistry 38 (13): 4045-4052

Semino,C., Allende,M.L., Bakkers,J., Spaink,H.P and Robbins,P.W. (1998). Expression of Rhizobium chitin oligosaccharide fucosyltransferase in zebrafish embryos disrupts normal development. Ann. N. Y. Acad. of Sci. 842: 49-54

Bakkers,J.,. Semino,C.E., Stroband,H.,. Kijne,J.W.,. Robbins,P.W. and Spaink,H.P. (1997). An important developmental role for oligosaccharides during early development of zebrafish. Proc. Natl. Acad. Sci USA. 94: 7982-7986

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