Publications

Bakkers group

Smith K.A., Joziasse I.C., Chocron S., van Dinther M., Guryev V., Verhoeven M.C., Rehmann H., van der Smagt J.J., Doevendans P.A., Cuppen E., Mulder B.J., Ten Dijke P., Bakkers J. (2009) Dominant-negative ALK2 allele associates with congenital heart defects. Circulation 119(24):3062-3069

Bakkers J, Verhoeven MC and Abdelilah-Seyfried S. (2009) Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis. Dev. Biol. 10.1016/j.ydbio.2009.04.01

e Pater E, Clijsters L, Marques S, Lin Y, Garavito-Aguilar ZV, Yelon D and Bakkers J. (2009) Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart. Development 10.1242/dev.030924

Marques IJ, Weiss FU, Vlecken DH, Nitsche C, Bakkers J, Lagendijk AC, Partecke LI, Heidecke C, Lerch MM and Bagowski CP (2009) Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model. BMC Cancer in press

Postel R, Vakeel P, Topczewski J, Knöll R, Bakkers J. (2008) Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex. Dev Biol. 318(1):92-101

Joziasse IC, van de Smagt JJ, Smith K, Bakkers J, Sieswerda GJ, Mulder BJ and Doevendans PA.(2008) Genes in congenital heart disease: atrioventricular valve formation. Basic Res Cardiol. 103(3):216-27

Krens SF, He S, Lamers GE, Meijer AH, Bakkers J, Schmidt T, Spaink HP and Snaar-Jagalska BE.(2008) Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation.Dev Biol. 15;319(2):370-83

Smith KA, Chocron S, von der Hardt S, de Pater E, Soufan A, Bussmann J, Schulte-Merker S, Hammerschmidt M and Bakkers J. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cellsDevelopmental Cell, 14; 287–297

Monteiro R, van Dinther M, Bakkers J, Wilkinson R, Patient R, Ten Dijke P and Mummery C.(2008) Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Dev Biol. 315(1):55-71

Bussmann J, Bakkers J, Schulte-Merker S.(2007). Early endocardial morphogenesis requires Scl/Tal1.PLoS Genetics, 3(8):e140.

Knoell R, Postel R, Wang J, Kraetzner R, Hennecke G, Murthy K, Rana B, Kube D, Knoell G, Schaefer K, Hayashi T, Kimura A, Schork N, Toliat M, Nuernberg P, Schultheiss P, Schaper W, Schaper J, Bos E, Van Eeden F, Peters P, Hasenfuss G, Chien K, and Bakkers J (2007). Laminin alpha 4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and in endothelial cells. Circulation, 116(5):515-25

Chocron S, Verhoeven M.C, Rentzsch F. Hammerschmidt M. and Bakkers J. (2007). Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points. Dev. Biol., 15;305(2):577-88

von der Hardt S, Bakkers J, Inbal A, Carvalho L, Solnica-Krezel L, Heisenberg CP, and Hammerschmidt M (2007).  The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating Ca2+-dependent cell adhesiveness. Current Biology, 17(6):475-87.

Thijssen VL, Postel R, Brandwijk RJ, Dings RP, Nesmelova I, Satijn S, Verhofstad N, Nakabeppu Y, Baum LG, Bakkers J, Mayo KH, Poirier F, Griffioen AW. (2006) Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proc Natl Acad Sci U S A, 103(43): 15975-15980

Meer van der D.L.M., Marques I.J., Leito J.T.D., Besser J., Bakkers J., Schoonheere E. and Bagowski. C.P. (2006) Zebrafish cypher is important for somite formation and heart development. Dev. Biol., 299(2):356-72

J. Bakkers, M. Camacho-Carvajal, M. Nowak, C. Kramer, B. Danger and M. Hammerschmidt (2005). Destabilization of deltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo.Cell Cycle. 2005 Jun;4(6):790-800

Rentzsch,F., Bakkers,J., Kramer,C. and Hammerschmidt,M. (2004) Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition. Dev. Dyn. 231: 750-757

Brembeck,F.H., Schwarz-Romond,T., Bakkers,J., Wilhelm,S., Hammerschmidt,M. and Birchmeier,W. (2004) Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. Genes Dev . 18(18):2225-2230

Bakkers,J., Kramer,C., Pothof,J., Quaedvlieg,N.E.M., Spaink,H.P. and Hammerschmidt,M. (2004) Hyaluronan synthase 2 (Has2) is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Development 132: 525-537

Schwarz-Romond,T., Asbrand,C., Bakkers,J., Kühl,M., Schaeffer,H., Huelsken,J., Behrens,J., Hammerschmidt,M. and Birchmeier,W (2002). The ankyrin repeat protein Diversin recruits Casein Kinase I epsilon to the b-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev. 16(16):2073-84

Bakkers,J., Hild,M., Kramer,C., Furutani-Seiki,M. and Hammerschmidt,M. (2002). Zebrafish deltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm. Dev Cell. ; 2(5):617-27

Lele,Z., Bakkers,J. and Hammerschmidt,M. (2001). Morpholino phenocopies of the swirl/bmp2b, snailhouse/bmp7, somitabun/smad5, minifin/tolloid, silberblick/wnt11 and pipetail/wnt5 mutations. Genesis 30: 190-194

Bakkers,J., Kijne,J.W. and Spaink,H.P. (1999). Function of chitin oligosaccharides in plant and animal development. In Chitin and chitinases, R.A.A. Muzzarelli and P. Jollès, eds. (Basel/Switzerland: Birkhäuser Verlag), pp. 69-81.

Kamst,E., Bakkers,J., Quaedvlieg,N.E.M., Pilling,J., Kijne,J.W., Lugtenberg, B.J.J. and Spaink,H.P. (1999). Chitin oligosaccharide synthesis by rhizobia and zebrafish embryos starts by glycosyl transfer to O4 of the reducing-terminal residue. Biochemistry 38 (13): 4045-4052

Semino,C., Allende,M.L., Bakkers,J., Spaink,H.P and Robbins,P.W. (1998). Expression of Rhizobium chitin oligosaccharide fucosyltransferase in zebrafish embryos disrupts normal development. Ann. N. Y. Acad. of Sci. 842: 49-54

Bakkers,J.,. Semino,C.E., Stroband,H.,. Kijne,J.W.,. Robbins,P.W. and Spaink,H.P. (1997). An important developmental role for oligosaccharides during early development of zebrafish. Proc. Natl. Acad. Sci USA. 94: 7982-7986

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