Bakkers group
Cardiac development and genetics
Wide ranges of congenital and acquired human diseases are associated with pathological conditions in heart formation. To understand the complex genetics of congenital heart defects we study cardiac development in the zebrafish model. We use forward and reverse genetics to identify novel genes that are required for normal heart development and use molecular and cellular techniques to characterize gene function in vivo. Subsequently, we use this information to screen for genetic variations in patients with congenital heart defects to better understand the genetics of the disease.
Our research group is incorporated in the Interuniversity Cardiology Institute of the Netherlands (ICIN).
About the research
Key publications
Smith, K., Noël, E., Thurlings, I., Rehmann, H., Chocron, S. and Bakkers, J. (2011) Bmp and Nodal Independently Regulate lefty1 Expression to Maintain Unilateral Nodal Activity During Left-Right Axis Specification in Zebrafish. PloS Gen. 7(9):e1002289
Lagendijk AK, Goumans MJ, Burkhard SB, Bakkers J. (2011) MicroRNA-23 Restricts Cardiac Valve Formation by Inhibiting Has2 and Extracellular Hyaluronic Acid Production. Circ. Res. 109:649-657
Smith, K.A., Joziasse, I.C., Chocron, S., van Dinther,M., Guryev, V., Verhoeven, M.C., Rehmann, H., van der Smagt, J.J., Doevendans, P.A., Cuppen, E., Mulder, B.J., ten Dijke, P., Bakkers, J. (2009) Dominant-negative ALK2 allele associates with congenital heart defects. Circulation 119: 3062-3069.
Smith, K.A., Chocron, S., von der Hardt, S., de Pater, E., Soufan, A., Bussmann, J., Schulte-Merker, S., Hammerschmidt, M., Bakkers, J. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev. Cell, 14: 287–297.
Bakkers,J., Hild,M., Kramer,C., Furutani-Seiki,M. and Hammerschmidt,M. (2002). Zebrafish ΔNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm. Dev Cell. ; 2(5):617-27. Highlighted in Nat. Rev. Neuroscience (2002) 3(6);416-417
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