Geert Kops obtained his PhD cum laude in 2001 from Utrecht University for his investigations into the oncogenic PI3K-PKB/Akt–FOXO pathway and its role in cellular proliferation. He then pursued postdoctoral studies in the lab of Don Cleveland at the Ludwig Institute for Cancer Research in La Jolla, USA, where he investigated molecular mechanisms of chromosome segregation. When the surf was up, however, he could be found in the Pacific Ocean. Geert returned to the Netherlands in 2005 as a group leader at UMC Utrecht, where he became Professor of Molecular Tumor Cell Biology in 2011. He was the head of the laboratory for Medical Oncology from 2011 to 2014. Geert joined the Hubrecht Institute in October 2015. His primary research interests include signaling networks that regulate chromosome segregation, evolution of cell division processes and the role of chromosomal instability in cancer. Geert is the recipient of the NVBMB prize 2004, the Von Freyburg medal in 2006 and the KNCV gold medal 2014, and was elected to the Young Academy of Europe (YAE) in 2013. He was awarded an ERC Starting Grant from the European Research Council in 2009 and a NWO-Vici grant in 2013. Geert serves on the scientific council of the Dutch Cancer Society (KWF Kankerbestrijding) and has co-developed ‘De Gemene Deler’, a teaching module for high schools about molecular mechanisms, cells and cancer.
Team members Kops
Jolien van Hooff
The trillions of cells in the human body were created by countless cycles of cell growth and division during development. These cycles continue during our lifetime to renew and repair tissues. Uncontrolled cell division cycles, however, cause cancer. A critical event for healthy cell division is the proper duplication and segregation of all chromosomes. We use a range of molecular biology, tissue culture and imaging technologies to understand 1) how error-free chromosome segregation is ensured molecularly; 2) how errors in chromosome segregation impact tumor development; 3) what the evolutionary origins and diversity of these processes are in eukaryotes.
Etemad B, Kuijt TEF, Kops GJPL. Kinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint. Nat Commun (2015) in press
PDF for personal use only
Hiruma, Y, Sacristan C, Pachis ST, Adamopoulos A, Kuijt T, Ubbink M, Von Castelmur E, Perrakis A, Kops GJPL. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling. Science 348 (2015), 1264-1267.
Drost J, Van Jaarsveld RH, Ponsioen B, Zimberlin C, Van Boxtel R, Buijs A, Sachs N, Overmeer RM, Offerhaus GJ, Schwank G, Begthel H, Korving J, Logtenberg M, Cuppen E, Snippert HJ, Medema JP, Kops GJPL, Clevers H. Sequential cancer mutations in cultured human intestinal stem cells. Nature 521 (2015), 43-7.
Vleugel M, Omerzu M, Groenewold V, Hadders MA, Lens SM, Kops GJPL. Sequential multisite phospho-regulation of KNL1-BUB3 interfaces at mitotic kinetochores. Mol Cell 57 (2015), 824-35.
Nijenhuis W, Vallardi G, Van den Dikkenberg A, Kops GJPL*, Saurin AT*. Negative feedback at kinetochores underlies a responsive spindle checkpoint signal. Nat Cell Biol. 16 (2014), 1257-64.
*equal contribution and correspondence.
Suijkerbuijk SJE, Vleugel M, Teixiera A, Kops GJPL. Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments. Dev Cell 23 (2012), 745-755.
Suijkerbuijk SJE, Van Dam TJP, Karagöz GE, Von Castelmur E, Hubner NC, Duarte AMS, Vleugel M, Perrakis A, Rüdiger SGD, Snel B, Kops GJPL. The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase. Dev Cell 22 (2012), 1321-9.
Janssen A, Van der Burg, M, Szuhai, K, Kops GJPL*, Medema RH*. Chromosome segregation errors as a cause of DNA damage and structural chromosome aberration. Science 333 (2011), 1895-8.
Janssen A, Kops GJPL*, Medema RH*. Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proc Natl Acad Sci U S A 106 (2009), 19108-13.
* equal contribution and correspondence
Jelluma N, Brenkman AB, Van den Broek NJF, Cruijsen CWA, Van Osch MHJ, Lens SMA, Medema RH and Kops GJPL. Mps1 phosphorylates borealin to control aurora B activity and chromosome alignment. Cell 132 (2008) 233-246.