Hans Clevers

Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA.

From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. From 2002-2012 he was director of the Hubrecht Institute in Utrecht. From 2012-2015 he was President of the Royal Netherlands Academy of Arts and Sciences (KNAW). Since June 1, 2015 he is director Research of the Princess Maxima Center for pediatric oncology.

Hans Clevers has been a member of the Royal Netherlands Academy of Arts and Sciences since 2000, a member of the American Academy of Arts and Sciences since 2012 and a member of the National Academy of Sciences of the USA since 2014. He is the recipient of several awards, including the Dutch Spinoza Award in 2001, the Swiss Louis Jeantet Prize in 2004, the Memorial Sloan-Kettering Katharine Berkan Judd Award in 2005, the Israeli Rabbi Shai Shacknai Memorial Prize in 2006, the Dutch Josephine Nefkens Prize for Cancer Research and the German Meyenburg Cancer Research Award in 2008, the Dutch Cancer Society Award in 2009, the United European Gastroenterology Federation (UEGF) Research Prize in 2010, the German Ernst Jung-Preis für Medizin in 2011, the French Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize, the Heineken Prize in 2012, the Breakthrough Prize in Life Sciences in 2013, the co-recipient of the 2015 ISSCR McEwen Award for Innovation and in 2016 the Academy Professor Prize and the Körber European Science Prize in 2016. He obtained two ERC Advanced Investigator grants (2008 and 2016). He is Chevalier de la Legion d’Honneur since 2005 and Knight in the Order of the Netherlands Lion since 2012.

h.clevers(at)hubrecht.eu

Team members Clevers

Huili Hu

Postdoc

Huili Hu

Karin Wind

Technician

Karin Wind

Oded Kopper

Postdoc

Oded Kopper

Janny van Eldik

Secretary
j.eldik@hubrecht.eu

Janny van Eldik

Wim de Lau

Senior Researcher

Wim de Lau

Onur Basak

Postdoc

Onur Basak

Helmut Gehart

Postdoc

Helmuth Gehart

Georg Busslinger

Postdoc

Georg Busslinger

Marvin Statia

Technician

Marvin Statia

Ariet Looyen

Secretary

Ariet Looyen

Dominique Wiener

Guest

Dominique Wiener

Farzin Pourfarzad

guest

Farzin Pourfarzad

Hans Clevers

clevers

Priyanca Asra

Technician

Priyanca Asra

Jinyi Su

Technician

Jinyi Su

Benaissa El Haddouti

Technician

Benaissa El Haddouti

Stieneke van den Brink

Lab Assistant

Stieneke van den Brink

Tulay Bayram

Projectleider

Tulay Bayram

Angelos Papaspyropoulos

Postdoc

Angelos Papaspyropoulos

Devanjali Dutta

Postdoc

Devanjali Dutta

Joep Beumer

PhD student

Joep Beumer

Johan van Es

Senior Researcher

Johan van Es

Inha Heo

Postdoc

Inha Heo

Sridevi Jaksani

Technician

Sridevi Jaksani

Emilio Ramos

Technician

Emilio Ramos

Carola Ammerlaan

Technician

Carola Ammerlaan

Kai Kretzschmar

Postdoc

Kai Kretzschmar

Jasper Mullenders

postdoc

Jasper Mullenders

Tomohiro Mizutani

Postdoc

Tomohiro Mizutani

Kadi Lõhmussaar

PhD Student

Kadi Lõhmussaar

Robert Vries

Rob-Vriesweb

Nilofar Ehsani

Technician

Nilofar Ehsani

Maaike van den Born

Technician

Maaike van den Born

Anjali Balgobind

Technician

Anjali Balgobind

Evelien de Jongh

Technician

Evelien de Jongh

Norman Sachs

Postdoc

Norman Sachs

Paco Peinado

guest

Paco Peinado

Yoshiyuki Tsukamoto

Postdoc

Yoshiyuki Tsukamoto

Ricardo Korporaal

Technician

Ricardo Korporaal

Sylvia Fernandez Boj

Postdoc

Sylvia Fernandes Boj

Else Driehuis

PhD Student

Else Driehuis

Yorick Post

PhD Students

Yorick Post

Lena Böttinger

Postdoc

Lena Böttinger

Tamana Mehraban

Technician

Tamana Mehraban

Jarno Drost

Postdoc

Jarno Drost

Karien Hamer

Technician

Karien Hamer

Frans Schutgens

PhD Student

Frans Schutgens

Harry Begthel

Lab Assistant

Harry Begthel

René Overmeer

Postdoc

René Overmeer

Kim Boonekamp

PhD student

Kim Boonekamp

Benedetta Artegiani

Postdoc

Benedetta Artegiani

Laura Zeinstra

Lab Assistant

Laura Zeinstra

Jeroen Korving

Lab Assistent

Jeroen Korving

Joyce Blokker

Technician

Joyce Blokker

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Research

Clevers_detaching sheet

Clevers: Lgr5 stem cells, Wnt signaling & cancer

Originally focused on T lymphocyte transcription factors, we cloned Tcf1 in 1991. With the discovery that Tcf factors are the final effectors of Wnt signaling, we changed our interests to the biology of Wnt signaling in intestinal self-renewal and cancer. We identified a series of adult tissue stem cells with the novel Lgr5 marker and technologies for long-term culture of these stem cells as epithelial organoids, currently our major focus of research

Read research

Key publications

Drost, J, van Jaarsveld, R.H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A.,Sachs, N., Overmeer, R.M., Offerhaus, G.J., Begthel, H. Korving, J., van de Wetering, M., Schwank, G. Logtenberg, M., Cuppen, E., Snippert, H.J., Medema, J.P., Kops, G. J. P. L., Clevers, H. Sequential cancer mutations in cultured human intestinal stem cells. Nature 521: 43-47 (2015)

van de Wetering, M., Francies, H.E., Francis, J.M., Bounova, G., Iorio, F., Pronk, A., van Houdt, W., van Gorp, J., Taylor-Weiner, A., Kester, L., McLaren-Douglas, A., Blokker, J., Jaksani, S., Bartfeld, S., Volckman, R., van Sluis, P., Li, V.S.W., Seepo, S., Sekhar Pedamallu, C., Cibulskis, C., Carter, S.L., McKenna, A., Lawrence, M.S., Lichtenstein, L., Stewart, C., Koster, J., Versteeg, R., van Oudenaarden, A., Saez-Rodriguez, J., Vries, R.G.J., Getz, G., Wessels, L., Stratton, M.R., McDermott, U., Meyerson, M., Garnett, M.J., Clevers, H. Prospective derivation of a ‘Living Organoid Biobank’ of colorectal cancer patients.
Cell 161: 933-945 (2015)

Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M., Ellis, E., van Wenum, M., Fuchs, S., de Ligt, J., van de Wetering, M., Sasaki, N., Boers, S., Kemperman, H., de Jonge, J. IJzermans, J., Niewenhuis, E., Hoekstra, R., Strom, S., Vries, R., van der Laan, L., Cuppen, E., Clevers, H. Long-term culture of genome-stable bipotent stem cells from adult human live. Cell 160: 299-312 (2015)

Sato, T., Vries, R., Snippert, H., van de Wetering, M., Barker, N., Stange, D., van Es, J., Abo, A., Kujala, P., Peters, P., Clevers, H. Single lgr5 gut stem cells build crypt-villus structures in vitro without a stromal niche. Nature 459 : 262-265 (2009)

Barker, N., van Es, J.H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Korving, J., Begthel, H., Peters, P.C., Clevers, H. Identification of stem cells in small intestine and colon by a marker gene LGR5. Nature 449: 1003-1007 (2007)

All publications

Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals
2016

Martti Maimets, Cecilia Rocchi, Reinier Bron, Sarah Pringle, Jeroen Kuipers, Ben N G Giepmans, Robert G J Vries, Hans Clevers, Gerald de Haan, Ronald van Os, Robert P Coppes

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
2016 in Cell Stem Cell

Dominic Grün, Mauro J Muraro, Jean-Charles Boisset, Kay Wiebrands, Anna Lyubimova, Gitanjali Dharmadhikari, Maaike van den Born, Johan van Es, Erik Jansen, Hans Clevers, Eelco J P de Koning, Alexander van Oudenaarden

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis
2016 in Science Translational Medicine

Johanna F Dekkers, Gitte Berkers, Evelien Kruisselbrink, Annelotte Vonk, Hugo R de Jonge, Hettie M Janssens, Inez Bronsveld, Eduard A van de Graaf, Edward E S Nieuwenhuis, Roderick H J Houwen, Frank P Vleggaar, Johanna C Escher, Yolanda B de Rijke, Christof J Majoor, Harry G M Heijerman, Karin M de Winter-de Groot, Hans Clevers, Cornelis K van der Ent, Jeffrey M Beekman

RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation
2016 in Gut

Helen H N Yan, Jeffrey C W Lai, Siu Lun Ho, Wai Keung Leung, Wai Lun Law, Janet F Y Lee, Anthony K W Chan, Wai Yin Tsui, Annie S Y Chan, Bernard C H Lee, Sarah S K Yue, Alice H Y Man, Hans Clevers, Siu Tsan Yuen, Suet Yi Leung

Modeling Development and Disease with Organoids
2016 in Cell

Hans Clevers

Model organoids provide new research opportunities for ductal pancreatic cancer
2016

Sylvia F Boj, Chang-Il Hwang, Lindsey A Baker, Dannielle D Engle, David A Tuveson, Hans Clevers

Organoid biobanking
2016 in EMBO reports

Sarah N Boers, Johannes Jm van Delden, Hans Clevers, Annelien L Bredenoord

CRISPR/Cas9-Mediated Genome Editing of Mouse Small Intestinal Organoids
2016 in Methods in Molecular Biology

Gerald Schwank, Hans Clevers

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype
2016 in EMBO Molecular Medicine

Evelyn Fessler, Jarno Drost, Sander R van Hooff, Janneke F Linnekamp, Xin Wang, Marnix Jansen, Felipe De Sousa E Melo, Pramudita R Prasetyanti, Joep Eg IJspeert, Marek Franitza, Peter Nürnberg, Carel Jm van Noesel, Evelien Dekker, Louis Vermeulen, Hans Clevers, Jan Paul Medema

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation
2016 in Cell Stem Cell

Carmen Dominguez-Brauer, Zhenyue Hao, Andrew J Elia, Jérôme M Fortin, Robert Nechanitzky, Patrick M Brauer, Yi Sheng, Miyeko D Mana, Iok In Christine Chio, Jillian Haight, Aaron Pollett, Robert Cairns, Leanne Tworzyanski, Satoshi Inoue, Colin Reardon, Ana Marques, Jennifer Silvester, Maureen A Cox, Andrew Wakeham, Omer H Yilmaz, David M Sabatini, Johan H van Es, Hans Clevers, Toshiro Sato, Tak W Mak

Modeling pancreatic cancer with organoids
2016

Lindsey A Baker, Hervé Tiriac, Hans Clevers, David A Tuveson

Tissue-specific designs of stem cell hierarchies
2016 in Nature Cell Biology

Jane E Visvader, Hans Clevers

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation
2016 in Nature Communications

Chuntao Zhao, Yaqi Deng, Lei Liu, Kun Yu, Liguo Zhang, Haibo Wang, Xuelian He, Jincheng Wang, Changqing Lu, Laiman N Wu, Qinjie Weng, Meng Mao, Jianrong Li, Johan H van Es, Mei Xin, Lee Parry, Steven A Goldman, Hans Clevers, Q Richard Lu

Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure
2016

Ewart W Kuijk, Shauna Rasmussen, Francis Blokzijl, Meritxell Huch, Helmuth Gehart, Pim Toonen, Harry Begthel, Hans Clevers, Aron M Geurts, Edwin Cuppen

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche
2016 in Nature

Henner F Farin, Ingrid Jordens, Mohammed H Mosa, Onur Basak, Jeroen Korving, Daniele V F Tauriello, Karin de Punder, Stephane Angers, Peter J Peters, Madelon M Maurice, Hans Clevers

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters
2016 in Cell Stem Cell

Paul W Tetteh, Onur Basak, Henner F Farin, Kay Wiebrands, Kai Kretzschmar, Harry Begthel, Maaike van den Born, Jeroen Korving, Frederic de Sauvage, Johan H van Es, Alexander van Oudenaarden, Hans Clevers

Organoid culture systems for prostate epithelial and cancer tissue
2016 in Nature Protocols

Jarno Drost, Wouter R Karthaus, Dong Gao, Else Driehuis, Charles L Sawyers, Yu Chen, Hans Clevers

Reparative inflammation takes charge of tissue regeneration
2016 in Nature

Michael Karin, Hans Clevers

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon
2016 in Proceedings of the National Academy of Sciences of the United States of America

Nobuo Sasaki, Norman Sachs, Kay Wiebrands, Saskia I J Ellenbroek, Arianna Fumagalli, Anna Lyubimova, Harry Begthel, Maaike van den Born, Johan H van Es, Wouter R Karthaus, Vivian S W Li, Carmen López-Iglesias, Peter J Peters, Jacco van Rheenen, Alexander van Oudenaarden, Hans Clevers

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
2016 in Nature Protocols

Laura Broutier, Amanda Andersson-Rolf, Christopher J Hindley, Sylvia F Boj, Hans Clevers, Bon-Kyoung Koo, Meritxell Huch