Hans Clevers

Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA.

From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. From 2002-2012 he was director of the Hubrecht Institute in Utrecht . From 2012-2015 he was President of the Royal Netherlands Academy of Arts and Sciences (KNAW). Hans is director research of the Princess Maxima Center for Pediatric Oncology since June 1, 2015.

Hans Clevers has been a member of the Royal Netherlands Academy of Arts and Sciences since 2000, a member of the American Academy of Arts and Sciences since 2012 and a member of the National Academy of Sciences of the USA  since 2014. He is the recipient of several awards, including the Dutch Spinoza Award in 2001, the Swiss Louis Jeantet Prize in 2004, the Memorial Sloan-Kettering Katharine Berkan Judd Award in 2005, the Israeli Rabbi Shai Shacknai Memorial Prize in 2006, the Dutch Josephine Nefkens Prize for Cancer Research and the German Meyenburg Cancer Research Award in 2008, the Dutch Cancer Society Award in 2009, the United European Gastroenterology Federation (UEGF) Research Prize in 2010, the German Ernst Jung-Preis für Medizin in 2011, the French Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize and the Heineken Prize in 2012 and the Breakthrough Prize in Life Sciences in 2013. He obtained an ERC Advanced Investigator grant in 2008. He is Chevalier de la Legion d’Honneur since 2005 and Knight in the Order of the Netherlands Lion since 2012.

h.clevers(at)hubrecht.eu

Team members Clevers

Nobuo Sasaki

Postdoc

Nobuo Sasaki

Kai Kretzschmar

Postdoc

Kai Kretzschmar

Sridevi Jaksani

Technician

Sridevi Jaksani

Inha Heo

Postdoc

Inha Heo

Yorick Post

PhD Students

Yorick Post

Jinyi Su

Technician

Jinyi Su

Marvin Statia

Marvin Statia

Marvin Statia

Helmut Gehart

Postdoc

Helmuth Gehart

Anjali Balgobind

Technician

Anjali Balgobind

Benedetta Artegiani

Postdoc

Benedetta Artegiani

Janny van Eldik

Secretary
test@test.nl

Janny van Eldik

Luc Teeven

PhD Student

Luc Teeven

Onur Basak

Postdoc

Onur Basak

Sylvia Fernandez Boj

Postdoc

Sylvia Fernandes Boj

Maaike van den Born

Technician

Maaike van den Born

Stieneke van den Brink

Lab Assistant

Stieneke van den Brink

Ricardo Korporaal

Technician

Ricardo Korporaal

Sepideh Derakhshan

Technician

Sepideh Derakshan

Laura Zeinstra

Lab Assistant

Laura Zeinstra

Robert Vries

Rob-Vriesweb

Johan van Es

Senior Researcher

Johan van Es

Joyce Blokker

Technician

Joyce Blokker

Frans Schutgens

PhD Student

Frans Schutgens

Benaissa El Haddouti

Technician

Benaissa El Haddouti

Wim de Lau

Senior Researcher

Wim de Lau

Ana Gracanin

Technician

Ana Gracanin

Hans Clevers

clevers

Karin Wind

Technician

Karin Wind

Jarno Drost

Postdoc

Jarno Drost

Angelos Papaspyropoulos

Postdoc

Angelos Papaspyropoulos

Emilio Ramos

Technician

Emilio Ramos

Karien Hamer

Technician

Karien Hamer

Devanjali Dutta

Postdoc

Devanjali Dutta

Tamana Mehraban

Technician

Tamana Mehraban

Jeroen Korving

Technician

Jeroen Korving

Marc van de Wetering

Senior Researcher

Marc van de Wetering

Norman Sachs

Postdoc

Norman Sachs

René Overmeer

Postdoc

René Overmeer

Harry Begthel

Lab Assistant

Harry Begthel

Oded Kopper

Postdoc

Oded Kopper

Else Driehuis

PhD Student

Else Driehuis

Tulay Bayram

Projectleider

Tulay Bayram

Nilofar Ehsani

Technician

Nilofar Ehsani

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Research

Clevers_detaching sheet

Clevers: Lgr5 stem cells, Wnt signaling & cancer

Originally focused on T lymphocyte transcription factors, we cloned Tcf1 in 1991. With the discovery that Tcf factors are the final effectors of Wnt signaling, we changed our interests to the biology of Wnt signaling in intestinal self-renewal and cancer. We identified a series of adult tissue stem cells with the novel Lgr5 marker and technologies for long-term culture of these stem cells as epithelial organoids, currently our major focus of research

Read research

Key publications

Drost, J, van Jaarsveld, R.H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A.,Sachs, N., Overmeer, R.M., Offerhaus, G.J., Begthel, H. Korving, J., van de Wetering, M., Schwank, G. Logtenberg, M., Cuppen, E., Snippert, H.J., Medema, J.P., Kops, G. J. P. L., Clevers, H. Sequential cancer mutations in cultured human intestinal stem cells. Nature 521: 43-47 (2015)

van de Wetering, M., Francies, H.E., Francis, J.M., Bounova, G., Iorio, F., Pronk, A., van Houdt, W., van Gorp, J., Taylor-Weiner, A., Kester, L., McLaren-Douglas, A., Blokker, J., Jaksani, S., Bartfeld, S., Volckman, R., van Sluis, P., Li, V.S.W., Seepo, S., Sekhar Pedamallu, C., Cibulskis, C., Carter, S.L., McKenna, A., Lawrence, M.S., Lichtenstein, L., Stewart, C., Koster, J., Versteeg, R., van Oudenaarden, A., Saez-Rodriguez, J., Vries, R.G.J., Getz, G., Wessels, L., Stratton, M.R., McDermott, U., Meyerson, M., Garnett, M.J., Clevers, H. Prospective derivation of a ‘Living Organoid Biobank’ of colorectal cancer patients.
Cell 161: 933-945 (2015)

Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M., Ellis, E., van Wenum, M., Fuchs, S., de Ligt, J., van de Wetering, M., Sasaki, N., Boers, S., Kemperman, H., de Jonge, J. IJzermans, J., Niewenhuis, E., Hoekstra, R., Strom, S., Vries, R., van der Laan, L., Cuppen, E., Clevers, H. Long-term culture of genome-stable bipotent stem cells from adult human live. Cell 160: 299-312 (2015)

Sato, T., Vries, R., Snippert, H., van de Wetering, M., Barker, N., Stange, D., van Es, J., Abo, A., Kujala, P., Peters, P., Clevers, H. Single lgr5 gut stem cells build crypt-villus structures in vitro without a stromal niche. Nature 459 : 262-265 (2009)

Barker, N., van Es, J.H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Korving, J., Begthel, H., Peters, P.C., Clevers, H. Identification of stem cells in small intestine and colon by a marker gene LGR5. Nature 449: 1003-1007 (2007)

All publications

Plasticity within stem cell hierarchies in mammalian epithelia
2015 in Trends in Cell Biology

Paul W Tetteh, Henner F Farin, Hans Clevers

Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts
2015 in Cell Stem Cell

Jurian Schuijers, Jan Philipp Junker, Michal Mokry, Pantelis Hatzis, Bon-Kyoung Koo, Valentina Sasselli, Laurens G van der Flier, Edwin Cuppen, Alexander van Oudenaarden, Hans Clevers

Organoid models of human and mouse ductal pancreatic cancer
2015 in Cell

Sylvia F Boj, Chang-Il Hwang, Lindsey A Baker, Iok In Christine Chio, Dannielle D Engle, Vincenzo Corbo, Myrthe Jager, Mariano Ponz-Sarvise, Hervé Tiriac, Mona S Spector, Ana Gracanin, Tobiloba Oni, Kenneth H Yu, Ruben van Boxtel, Meritxell Huch, Keith D Rivera, John P Wilson, Michael E Feigin, Daniel Öhlund, Abram Handly-Santana, Christine M Ardito-Abraham, Michael Ludwig, Ela Elyada, Brinda Alagesan, Giulia Biffi, Georgi N Yordanov, Bethany Delcuze, Brianna Creighton, Kevin Wright, Youngkyu Park, Folkert H M Morsink, I Quintus Molenaar, Inne H Borel Rinkes, Edwin Cuppen, Yuan Hao, Ying Jin, Isaac J Nijman, Christine Iacobuzio-Donahue, Steven D Leach, Darryl J Pappin, Molly Hammell, David S Klimstra, Olca Basturk, Ralph H Hruban, George Johan Offerhaus, Robert G J Vries, Hans Clevers, David A Tuveson

Long-term culture of genome-stable bipotent stem cells from adult human liver
2015 in Cell

Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl, Monique M A Verstegen, Ewa Ellis, Martien van Wenum, Sabine A Fuchs, Joep de Ligt, Marc van de Wetering, Nobuo Sasaki, Susanne J Boers, Hans Kemperman, Jeroen de Jonge, Jan N M Ijzermans, Edward E S Nieuwenhuis, Ruurdtje Hoekstra, Stephen Strom, Robert R G Vries, Luc J W van der Laan, Edwin Cuppen, Hans Clevers

An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth
2015 in Science Translational Medicine

Parag Kundu, Maria Genander, Klas Strååt, Johanna Classon, Rachel A Ridgway, Ee Hong Tan, Jan Björk, Anna Martling, Johan van Es, Owen J Sansom, Hans Clevers, Sven Pettersson, Jonas Frisén

Premigratory and migratory neural crest cells are multipotent in vivo
2015 in Cell Stem Cell

Arianna Baggiolini, Sandra Varum, José María Mateos, Damiano Bettosini, Nessy John, Mario Bonalli, Urs Ziegler, Leda Dimou, Hans Clevers, Reinhard Furrer, Lukas Sommer

Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development
2015 in Journal of Pathology

Robbert DA Weren, Ramprasath Venkatachalam, Jean-Baptiste Cazier, Henner F Farin, C Marleen Kets, Richarda M de Voer, Lilian Vreede, Eugène Tp Verwiel, Monique van Asseldonk, Eveline J Kamping, Lambertus A Kiemeney, Kornelia Neveling, Katja Kh Aben, Luis Carvajal-Carmona, Iris D Nagtegaal, Hans K Schackert, Hans Clevers, Marc van de Wetering, Ian P Tomlinson, Marjolijn Jl Ligtenberg, Nicoline Hoogerbrugge, Ad Geurts van Kessel, Roland P Kuiper

Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations
2015

Johan H van Es, Hans Clevers

Microbiota controls the homeostasis of glial cells in the gut lamina propria
2015 in Neuron

Panagiotis S Kabouridis, Reena Lasrado, Sarah McCallum, Song Hui Chng, Hugo J Snippert, Hans Clevers, Sven Pettersson, Vassilis Pachnis

Targeting development of incretin-producing cells increases insulin secretion
2015 in Journal of Clinical Investigation

Natalia Petersen, Frank Reimann, Johan H van Es, Bernard M van den Berg, Chantal Kroone, Ramona Pais, Erik Jansen, Hans Clevers, Fiona M Gribble, Eelco J P de Koning

In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection
2015 in Gastroenterology

Sina Bartfeld, Tülay Bayram, Marc van de Wetering, Meritxell Huch, Harry Begthel, Pekka Kujala, Robert Vries, Peter J Peters, Hans Clevers

Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia
2015 in Proceedings of the National Academy of Sciences of the United States of America

Bon-Kyoung Koo, Johan H van Es, Maaike van den Born, Hans Clevers

Repairing organs
2015 in Trends in Genetics

Helmuth Gehart, Hans Clevers

Q&A
2015 in Nature

Hans Clevers, Eric Bender

Prospective derivation of a living organoid biobank of colorectal cancer patients
2015 in Cell

Marc van de Wetering, Hayley E Francies, Joshua M Francis, Gergana Bounova, Francesco Iorio, Apollo Pronk, Winan van Houdt, Joost van Gorp, Amaro Taylor-Weiner, Lennart Kester, Anne McLaren-Douglas, Joyce Blokker, Sridevi Jaksani, Sina Bartfeld, Richard Volckman, Peter van Sluis, Vivian S W Li, Sara Seepo, Chandra Sekhar Pedamallu, Kristian Cibulskis, Scott L Carter, Aaron McKenna, Michael S Lawrence, Lee Lichtenstein, Chip Stewart, Jan Koster, Rogier Versteeg, Alexander van Oudenaarden, Julio Saez-Rodriguez, Robert G J Vries, Gad Getz, Lodewyk Wessels, Michael R Stratton, Ultan McDermott, Matthew Meyerson, Mathew J Garnett, Hans Clevers

Sequential cancer mutations in cultured human intestinal stem cells
2015 in Nature

Jarno Drost, Richard H van Jaarsveld, Bas Ponsioen, Cheryl Zimberlin, Ruben van Boxtel, Arjan Buijs, Norman Sachs, René M Overmeer, G Johan Offerhaus, Harry Begthel, Jeroen Korving, Marc van de Wetering, Gerald Schwank, Meike Logtenberg, Edwin Cuppen, Hugo J Snippert, Jan Paul Medema, Geert J P L Kops, Hans Clevers

Efficient intracellular delivery of native proteins
2015 in Cell

Diego S D'Astolfo, Romina J Pagliero, Anita Pras, Wouter R Karthaus, Hans Clevers, Vikram Prasad, Robert Jan Lebbink, Holger Rehmann, Niels Geijsen

Frizzled7 functions as a wnt receptor in intestinal epithelial lgr5(+) stem cells
2015

Dustin J Flanagan, Toby J Phesse, Nick Barker, Renate H M Schwab, Nancy Amin, Jordane Malaterre, Daniel E Stange, Cameron J Nowell, Scott A Currie, Jarel T S Saw, Eva Beuchert, Robert G Ramsay, Owen J Sansom, Matthias Ernst, Hans Clevers, Elizabeth Vincan

Discovery of molecular markers to discriminate corneal endothelial cells in the human body
2015 in PLoS One

Masahito Yoshihara, Hiroko Ohmiya, Susumu Hara, Satoshi Kawasaki, Yoshihide Hayashizaki, Masayoshi Itoh, Hideya Kawaji, Motokazu Tsujikawa, Kohji Nishida, FANTOM consortium, J.C. Clevers, M.L. van de Wetering

Single-cell messenger RNA sequencing reveals rare intestinal cell types
2015 in Nature

Dominic Grün, Anna Lyubimova, Lennart Kester, Kay Wiebrands, Onur Basak, Nobuo Sasaki, Hans Clevers, Alexander van Oudenaarden